Diversity, pharmacology and synthesis of bergenin and its derivatives: Potential materials for therapeutic usages (original) (raw)
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Chemistry and Pharmacology of Bergenin or Its Derivatives: A Promising Molecule
Biomolecules
Bergenin is a glycosidic derivative of trihydroxybenzoic acid that was discovered in 1880 by Garreau and Machelart from the rhizomes of the medicinal plant Bergenia crassifolia (currently: Saxifraga crassifolia—Saxifragaceae), though was later isolated from several other plant sources. Since its first report, it has aroused interest because it has several pharmacological activities, mainly antioxidant and anti-inflammatory. In addition to this, bergenin has shown potential antimalarial, antileishmanial, trypanocidal, antiviral, antibacterial, antifungal, antinociceptive, antiarthritic, antiulcerogenic, antidiabetic/antiobesity, antiarrhythmic, anticancer, hepatoprotective, neuroprotective and cardioprotective activities. Thus, this review aimed to describe the sources of isolation of bergenin and its in vitro and in vivo biological and pharmacological activities. Bergenin is distributed in many plant species (at least 112 species belonging to 34 families). Both its derivatives (natu...
2020
Bergenia ciliata commonly known as Pashanbheda is renowned for numerous pharmacological activities. Rural communities from Himalaya region use B. ciliata for the treatment of the number of human ailments.[1] Mixture of polyphenolic compounds mainly bergenin, tannic acid, catechin, and other number of phytochemicals makes B. ciliata as one of the most explored plants.[2,3] The plant is a part of the number of ayurvedic formulations and rhizomes of Bergenia species are reported to possess antilithiatic activity.[4] Bergenin (Bergenin [BGE]) [Figure 1] also known as cuscutin, one
Poly pharmacological activities of Bergenia species
International Journal of Pharmaceutical Sciences Review and Research
Bergenia species are evergreen herb belonging to the family saxifragaceae. The rhizomes of these plants are used in the indigenous system of medicines. There are three species of Bergenia, namely B. ligulata, B. ciliata and B. stracheyi. The rhizome and other parts of B. ligulata is used in urinary bladder stone, antilithic activity diuretic activity, anti-bradykinin activity, antiviral activity, antipyretic activity, antibacterial, anti inflammatory, hepatoprotective activity, insecticidal activity, α-glucosidase activity and all these activities of the plant is due to presence of its constituents like; β-Sitosterol, Tannic acid, Stigmesterol, Gallic acid, Bergenin, (+)-Afzelechin, (+)-afzelechin, (+)-afzelechin tetraccetate, (+)-5,7,4'-trimethoxyafzelechin, (+)-tetramethoxyazelechin, (+)-3-acetyl-5,7,4'-trimethoxyafzelechin. The second species is B ciliata, have antitussive, antiulcer, antioxidant, antibacterial, hypoglycemic, toxicological activity. The plant contains Tan...
Bergenin Content and Free Radical Scavenging Activity of Bergenia Extracts
Natural Product Communications, 2015
Our research was focused on the evaluation of bergenin content and free radical scavenging activity of extracts prepared from three different species of Bergenia - B. crassifolia (L.) Fritsch., B. ciliata (Haw.) Sternb. and B. x ornata Stein. collected during different seasons. Using an HPLC method, the highest total amount of bergenin was revealed in the leaves of B. x ornata and B. crassifolia (4.9 - 5.1 mg.g−1). Free radical scavenging power was determined by two methods - FRAP and NADH. The best free radical scavengers were B. crassifolia (FRAP: 6.7 - 15.9 mg GAE.100g−1; NADH: 20.3 - 50.9%) and B. ornata (FRAP: 13.7 - 15.2 mg GAE.100g−1; NADH: 29.3 - 31.1%). The lowest content of bergenin and the weakest radical scavenger was B. ciliata (bergenin: 3.1 mg.g−1; FRAP: 5.5 - 11.0 mg GAE.100g−1; NADH: 23.2 - 25.6%). The presence of a large percentage of bergenin is responsible for the radical scavenging activity, as shown by the results from the FRAP and NADH assays. Significant, pos...
Plants
The influence of medicinal plants on humanity spans time immemorial. These plants are also used at present with local and tribal peoples for the cures of various illnesses. Nature has produced an immense number of medicinal plants, which directly or indirectly help to treat various ailments and have numerous applications in the fields of pharmaceuticals, agriculture, food flavors and preservatives, aromas, and cosmetics. Bergenia pacumbis (Buch.-Ham. ex D.Don) C.Y.Wu & J.T.Pan (synonym: Bergenia ligulate Engl.), is an important medicinal plant belonging to the Saxifragaceae family, and not to be confused with Bergenia ciliata (Haw.) Sternb., and is popularly known as Pashanbheda (meaning to dissolve the kidney stone). This plant is a rich source of secondary metabolites (SMs) such as coumarins, flavonoids, benzenoids, lactones, tannins, phenols, and sterols, which make this plant a highly valued medicinal herb with a broad spectrum of pharmacological activities such as anti-urolithi...