Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn (original) (raw)

AI-generated Abstract

Tranexamic acid (TXA), an antifibrinolytic agent, is associated with adverse effects such as seizures and pain when used intrathecally, potentially due to its impact on spinal dorsal horn neurons. This research investigates TXA's effects, revealing that it increases neuronal excitability and induces pain-like behaviors in rats. The study employs whole-cell patch-clamp techniques, demonstrating that TXA inhibits GABA A and glycine receptors, enhancing excitatory glutamatergic transmission and facilitating ERK activation in dorsal horn neurons. These findings elucidate the mechanism by which TXA evokes pain, highlighting its role in impairing inhibitory signaling in the spinal cord.

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