The role of sweet taste in satiation and satiety (original) (raw)
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Enhanced sweet taste perception in obesity: Joint analysis of gustatory data from multiple studies
Frontiers in Nutrition
IntroductionWhile sweet taste perception is a potential determinant of feeding behavior in obesity, the supporting evidence is inconsistent and is typically associated with methodological limitations. Notably, possible associations between sweet taste perception and measures of food reward remain undetermined.Materials and methodsWe conducted a cross-sectional analysis comparing 246 individuals with severe obesity and 174 healthy volunteers using a validated method for taste perception assessment. We included gustatory variables, namely intensity and pleasantness ratings of sour, salt, sweet, and bitter tastants, and taste thresholds assessed by electrogustometry. Reward-related feeding behavior, including hedonic hunger, food addiction, feeding behavior traits, and acceptance of foods and alcohol, was evaluated using self-rated scales for comparison with gustatory measures.ResultIn logistic regressions adjusted for age, gender, educational level, and research center, we found that ...
Sweet taste reactivity and satiety
Nutrition Research, 1997
In this investigation the effect of different levels of satiety and food intake on sweet taste reactivity was studied. Two foods differing in nutrient composition and satiating power were used. Sweet taste reactivity was determined by means of a triangular test, using glucose as the stimulus. This study shows that. immediately after eating, sweet taste reactivity depends on the levels of the satiety reached and is correlated to the sensation of satiety. fullness and desire to eat. Furthermore. the food determining the highest change in the sweet taste reactivity is the more satiating.
Appetite, 2020
Sensory-specific satiety (SSS) describes a reduction in the pleasantness of the taste of (momentary liking) and desire to consume a food that occurs with consumption, compared with the relative preservation of liking and desire for uneaten foods. We conducted three studies in healthy female and male participants to test whether SSS generalises from sweet drinks to sweet foods. Studies 1 (n = 40) and 2 (n = 64) used a two-condition cross-over design. Participants consumed non-carbonated, fruit squash drinks sweetened with lowcalorie sweeteners (LCS) versus water and evaluated various food and drink samples (stimuli). Generalisation of SSS was evident across all sweet stimuli, without an effect on non-sweet (savoury) stimuli. These SSS effects were present when measured shortly after consumption of the sweet drink, but not 2 hours later. There was no evidence of a 'rebound' increase above baseline in liking or desire to consume sweet foods 2 hours after the sweet drink versus water. In study 3, 51 participants consumed labelled and branded 500 ml cola and water drinks (4 conditions, cross-over design) immediately before and during ad libitum consumption of sweet and non-sweet snack foods. Compared with still water, 'diet' (LCSsweetened) cola reduced sweet food intake, but not total ad libitum intake. Carbonated water decreased hunger and increased fullness compared with still water, without differentially affecting thirst. Energy compensation from the ad libitum snacks for consumption of sugar-containing cola averaged only 20%. Together, these results demonstrate that consumption of LCS drinks acutely decreases desire for sweet foods, which supports their use in place of sugar-sweetened drinks. Further studies on the effects of carbonation of appetite are warranted.
British Journal of Nutrition, 2011
In vitro, both carbohydrate sugars and artificial sweeteners (AS) stimulate the secretion of glucagon-like peptide-1 (GLP-1). It has been suggested that the gut tastes sugars and AS through the same mechanisms as the tongue, with potential effects on gut hormone release. We investigated whether the human gut responds in the same way to AS and carbohydrate sugars, which are perceived by lingual taste as equisweet. We focused on the secretion of gastrointestinal (GI) satiety peptides in relation to appetite perception. We performed a placebo-controlled, double-blind, six-way, cross-over trial including twelve healthy subjects. On separate days, each subject received an intragastric infusion of glucose, fructose or an AS (aspartame, acesulfame K and sucralose) dissolved in 250 ml of water or water only (control). In a second part, four subjects received an intragastric infusion of the non-sweet, non-metabolisable sugar analogue 2-deoxy-d-glucose. Glucose stimulated GLP-1 (P = 0·002) an...
Sweet Taste Signaling: The Core Pathways and Regulatory Mechanisms
International Journal of Molecular Sciences
Sweet taste, a proxy for sugar-derived calories, is an important driver of food intake, and animals have evolved robust molecular and cellular machinery for sweet taste signaling. The overconsumption of sugar-derived calories is a major driver of obesity and other metabolic diseases. A fine-grained appreciation of the dynamic regulation of sweet taste signaling mechanisms will be required for designing novel noncaloric sweeteners with better hedonic and metabolic profiles and improved consumer acceptance. Sweet taste receptor cells express at least two signaling pathways, one mediated by a heterodimeric G-protein coupled receptor encoded by taste 1 receptor members 2 and 3 (TAS1R2 + TAS1R3) genes and another by glucose transporters and the ATP-gated potassium (KATP) channel. Despite these important discoveries, we do not fully understand the mechanisms regulating sweet taste signaling. We will introduce the core components of the above sweet taste signaling pathways and the rational...
Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation
Frontiers in Human Neuroscience
Sweetness is the preferred taste of humans and many animals, likely because sugars are a primary source of energy. In many mammals, sweet compounds are sensed in the tongue by the gustatory organ, the taste buds. Here, a group of taste bud cells expresses a canonical sweet taste receptor, whose activation induces Ca2+ rise, cell depolarization and ATP release to communicate with afferent gustatory nerves. The discovery of the sweet taste receptor, 20 years ago, was a milestone in the understanding of sweet signal transduction and is described here from a historical perspective. Our review briefly summarizes the major findings of the canonical sweet taste pathway, and then focuses on molecular details, about the related downstream signaling, that are still elusive or have been neglected. In this context, we discuss evidence supporting the existence of an alternative pathway, independent of the sweet taste receptor, to sense sugars and its proposed role in glucose homeostasis. Further...
Taste and the regulation of food intake
Revista Eletronica Gestão & Saúde, 2017
A modest archetypal of satiation is that it boils down primarily to two categories of signals transmitted from the gastrointestinal tract to the brain: stomach and intestine sensing and metabolism. Novel investigations endow us with the view that an extension of this traditional model is conceivable and called for, wherein intestinal satiation is the byproduct not only from signals related to the caloric content of ingested nutrients, but also from noncaloric properties of 'tastant molecules' in foodstuff. On this paper we discuss a recently published paper regarding the impact of tastants (e.g., noncaloric substance widely used as taste enhancers) on hunger and food intake. We gather the in vivo results (nasoduodenal infusions of tastants) with a recently developed mathematical model for ghrelin by the author and co-workers and we successfully replicate in silico part of the findings. The key results from the abovementioned paper and replicated herein is that tastant can in...