A Computational Model of Memories Disruption in Alzheimer Disease (original) (raw)

Abstract

Objectives: Memory lose takes place in an artificial koniocortex network when calcium-homeostasis impairment is simulated. According to the calcium dysregulation hypothesis of Alzheimer Disease, calcium dysregulation affects intrinsic plasticity. Intrinsic plasticity is the property of real neurons of adapting their firing thresholds according to the neurons activation regime: when a neuron is intensely stimulated it increases its firing threshold so that it becomes less responsive. On the contrary, when a neuron is scarcely stimulated, it reduces its firing threshold so that it is more prone to fire. Methods: A computational model of the koniocotex was trained with alphanumerical patterns, exhibiting successful learning capabilities. Successful learning was confirmed by stimulating each of the spiny stellate neurons of the model, and checking whether original alphanumerical patterns were recovered. Results: Due to calcium dysregulation, intrinsic plasticity might be impaired in eld...

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