Childhood non-Hodgkin\u27s Lymphoma: An immunophenotypic analysis (original) (raw)
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Childhood non-Hodgkin's lymphoma: an immunophenotypic analysis
JPMA. The Journal of the Pakistan Medical Association, 2000
OBJECTIVE To observe the frequency of histological subtypes of childhood non-Hodgkin's lymphoma and its immunohistochemical profile. SETTING All cases of non-Hodgkin's lymphoma diagnosed in children (< 15 years) in the section of histopathology at the Aga Khan University Hospital Karachi during the period of three years. METHODS These consecutive cases were evaluated on H&E stained sections and then immunohistochemistry analysis of these tumors was performed by employing Peroxidase Anti-Peroxidase (PAP) technique. RESULTS The present series included 61 cases of non-Hodgkin's lymphoma. NHL was more common in males as compared to females with male to female ratio of 5.8:1. High grade NHL comprised 87% of childhood lymphoma. The mode of presentation in majority of NHL (57%) was extranodal. Burkitt's lymphoma (33%) was the most prevalent histological subtypes, followed by lymphoblastic (28%), diffuse large cell (15%), diffuse mix small and large cell (13%), small non ...
2016
BackgroundNonHodgkin lymphoma (NHL) is one of the most frequent malignancies in children and adolescents. It represents lymphoid malignancies with diverse clinicopathological and biological features. There are very few studies on the frequency and distribution of NHL in this age group classified according to the WHO classification of 2008. A total of 246 cases with lymphoma were diagnosed in pediatric and adolescent patients over a period of five years, of which NHL accounted for 125 cases. The age, gender, anatomical site and distribution of the different subtypes of NHL were analyzed and compared with similar studies. ResultThe results of our study were comparable to similar studies from India. T-lymphoblastic lymphoma (TLBL) was the most common NHL. Other common subtypes included Burkitt lymphoma (BL), diffuse large B cell lymphoma (DLBCL) and Anaplastic large cell lymphoma (ALCL). ConclusionThe distribution of different subtypes of NHL is similar to other studies from India and ...
Dhaka Shishu (Children) Hospital Journal
Background: Non-Hodgkin Lymphoma (NHL) is the third most common childhood malignancy. With histopathology based intensive chemotherapy and CNS-directed therapy, survival can reach more than 80%. Objective: The study was conducted to observe the clinico-pathological findings of NHL in Bangladeshi children. Methods: A prospective observational study was conducted in the Paediatric Haematology and Oncology Department of BSMMU from June 2012 to December 2012. Newly diagnosed NHL patients were included in the study. Patient’s initial clinical presentations, time interval from onset of symptoms to diagnosis were recorded. Diagnostic and staging workups were done by CBC, biochemistry, radio-imaging, histopathology (FNAC/excision biopsy), serous fluids/CSF cytology (cytospin), and bone marrow aspiration. Result: Among the 34 patients, BL had preponderance (n=23, 68%) then LL. Median age was 7.6 years. Male: female ratio was 2.1:1. Delayed diagnosis was found in 59% patient. Primary sites we...
Childhood non-Hodgkin malignant lymphomas: A clinicopathologic retrospective study
Medical and Pediatric Oncology, 1979
Between 1968 and 1975,44 evaluable children under 16 years of age with the histologic diagnosis of non-Hodgkin malignant lymphoma (ML) were treated at the lstituto Nazionale Tumori of Milan. Histologic diagnoses were reclassified as follows: 13 lymphoblastic (others) ML, 15 convoluted cell type lymphoblastic ML, 9 Burkitt type ML, and 7 immunoblastic ML. Only 36% of the patients had stage I and I1 disease. At diagnosis 25% showed malignant cells in the bone marrow smears. Bone marrow infiltration was particularly frequent in the convoluted cell type lymphoblastic M L and in the lymphoblastic (others) M L subgroups. Burkitt type M L frequently was associated with abdominal lesions and subsequently a high incidence of central nervous system involvement. Patients with stage I and I1 M L were encountered mostly in the immunoblastic M L subgroup. After 1973 more intensive chemotherapy plus radiotherapy seems to have slightly improved the survival of the patients, except in the Burkitt type M L subgroup.
Journal of Cancer Therapy, 2015
Background: Non-Hodgkin's lymphoma is an aggressive malignant disease in children and adolescents. Although it is the fourth most common malignancy in Saudi children as reported in Saudi cancer registry, less information is available about pediatric Non-Hodgkin lymphoma and its outcome in Saudi Arabia. Study Objectives: To provide demographic data, disease characteristics, treatment protocol, toxicity and outcome of treatment in children & adolescents with Non-Hodgkin's lymphoma treated at KFMC. This study will form base line for future studies about pediatric Non-Hodgkin's lymphoma in KFMC, which may help to improve outcome for children with cancer in Saudi Arabia. Study Patients and Method: We retrospectively analyzed 28 children and adolescents diagnosed to have Non-Hodgkin's lymphoma at KFMC between December 2006 and December 2013, followed-up through June 2014. Results: Of the 28 patients, 10 (35.7%) girls and 18 (64.3%) boys, the male-to-female ratio was 1.8; 1. The median age at time of diagnosis was 6.4 years old (range 2.0 to 13.0 years old). The majority of patients (64.3%) were aged between 5 and 12 years old. Burkitt's lymphoma BL/BLL was the most common pathological subtype (60.7%), and DLBCL was the second most common subtype (21.4%). Abdominal and Retroperitoneal involvement was the most common primary site (78.6%) including the ileocaecal region. Most of the children presented with advanced Stage III and IV (75%), Cytogenetic study which screens specif-* Corresponding author. N. A. Mobark et al. 300 ically for the t (8; 14) (q24; q32) a characteristic genetic feature of Burkitt's Lymphoma was obtained from 21 patients, variant rearrangement was observed in 3/21 samples and complex chromosomes karyotype in addition to IGH/MYC rearrangement was observed in 2/21 samples. Those patients presented with very aggressive lymphoma and combined BM and CNS involvement. We use the French-American-British Mature B-Cell Lymphoma 96 Protocol (FAB LMB 96) for treatment fornewly diagnosed Mature B-Cell type NHL and high risk ALL CCG 1961 Protocol for lymphoblastic lymphoma and international Anaplastic Large Cell Lymphoma 99 Study Protocol for ALCL. The median follow-up in patients not experiencing an adverse event was 53.1 months. The estimated 3-year EFE and OS rates in the entire cohort of patients with newly diagnosed NHL treated in the KFMC were 85.2% and 89.2% respectively; Overall survival (OS) rate of patients with mature B-cell-NHL was 88.9%. Conclusion: The outcomes and survival in our small series appeared to be excellent compared with those reported in other international trials even though most of our patients presented in advanced stage of the disease. We feel that the importance of the current study is to document the relative distribution of various types of pediatric non-Hodgkin's lymphomas and age-specific distribution in different Histological subtypes.
Presentation of lymphoma in childhood
IAR Consortium, 2023
Background: Lymphomas are the third most common group of malignant tumor in children; they are rapidly growing neoplasm, with a propensity fewer spread dissemination, and should be investigation and treated as expeditiously possible Aim of the study: To study epidemiological, clinical & pathological features of lymphoma in Iraqi children Method: Over a period of 7 years (from January 2003 to December 2009) all the cases diagnosed & treated as lymphoma in the oncology unit of the Child Central Teaching Hospital (Baghdad) were reviewed retrospectively. Result:-the total number of cases studied was 118 cases.40% of cases diagnosed during (2003,2004) while only 5% diagnose in 2007,NHL represent the most common type (80.5%) and HL account for (19.4%). regarding HL : the age range was between (2years-15 years), median age was 7 years , peak age was between (5-9 years) , male /female ratio was 5:1, cervical LAP represents the most common mode of presentation (95.6%). Mixed cellularity was the most histopathological subtype (60.8%), & most of patients with advanced disease stage (III, IV) (65.1%). Regarding NHL: the age range was between (9m-16 years), median age was 8 years, peak age was between (5-9 years) and male /female ratio was 2.1:1. Abdominal mass (distention) was the most common mode of presentation (61%). BL&BLL was the most common subtype (56.8%), &most of patient presented with advanced disease (stage III&IV) 86.2%. Conclusion:-the study show male predominant in both type of lymphoma,NHL was the most common subtype of lymphoma, MC the most common subtype of HL while BL&BLL was the most common subtype of NHL and high percentage of patients (HL&NHL) presented with advanced disease.
Pediatric Non Hodgkin's Lymphomas
ijbc.ir
Pediatric non-Hodgkin lymphoma (NHL) is a diverse collection of diseases, and results from malignant proliferation of lymphoid cells and immune system. NHL involves throughout the body, but bone and primary central nervous system (CNS) lymphomas are its rare presentations. The incidence of NHL in childhood differs according to age and geographic area, but overall constitutes 8-10% of all malignancies in children between 5-19 years of age. The preferred pathologic and molecular biology classification for NHL is based on currently recognized histologic (morphologic), immunophenotypic, and genetic features, and their clinical presentation and course. The clinical manifestations of NHL in children depend on pathological subtype and primary sites of disease. Abdomen and mediastinum are the most frequent primary sites of involvement. Most centers use st. Jude staging system and diagnostic workup. Most patients present with advanced stage and systemic disease. According to pathophysiology of childhood NHL, treatment strategy is based on extent of dissemination and requires attention to emergent complications. Modern treatments have caused dramatic improvement in childhood NHL. We need well conducted international studies in all parts of the world to increase our knowledge to acieve better outcome and prevent late effects in children.
Asian Pacific journal of cancer prevention : APJCP, 2014
Data regarding childhood and adolescent non Hodgkin lymphomas in Iran are limited. The aim of this study was to assess the epidemiological and histomorphological features and survival of affected patients in our center. The clinicopathologic features and outcome of 44 children and adolescents with non Hodgkin lymphoma diagnosed during 2004-2012, were investigated retrospectively. The influence of potential prognostic parameters in overall survival was investigated by log-rank test and Cox regression analysis. The mean age at presentation was 13.8 ± 6.16 years with a male predilection (M: F=3:1). Malignant lymphoma, not otherwise specified, diffuse large cell lymphoma and Burkitt lymphoma were the three most common histological types observed. The tumors were 36.4% intermediate grade, 27.3% high grade and 34.1% belonged to the malignant lymphoma not otherwise specified group. Immunohistochemistry findings were available in 39 cases. Out of these cases 33 (84.6%) had B cell lineage, 4...
Clinico-pathological correlations in the Kiel classification of non-Hodgkin's lymphomata in children
Scandinavian journal of haematology, 1978
The rapid development of chemotherapy and radiotherapy during the last decade makes an increasing demand for a reliable classification of malignant non-Hodgkin's lymphomas. This is especially important in children since in this age group the lymphomas show a much worse prognosis than in adults. An attempt at a modern classification is offered by the so-called Kiel classification. 38 children with non-Hodgkin's lymphomas previously classified according to Rappaport were re-evaluated according to the Kiel system. Reclassification was technically feasible in 26 patients. There was good agreement on typing between the two independently working cytopathologists. 3 patients proved to be cases of histiocytic medullary reticulosis. Among the remaining patients, a much larger variety of histological subgroups was seen than in the one published paediatric series of Lennert. 17 patients had high-grade malignant lymphomas with lymphoblastic lymphomas predominating. Some clinical correla...