The Chemical Transmission Mechanism of Excitation-Contraction Coupling in Skeletal Muscle (original) (raw)

Physiology, 1987

Abstract

There is a temperature-dependent lag between depolarization of transverse tubules by the action potential and onset of calcium release from the sacromplasmic reticulum that reveals the occurrence of a chemical step in excitation-contraction coupling. Recent studies suggest that in vertebrate muscle inositol 1,4,5-trisphosphate may act as a chemical link in this process.

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