Solitary Brain Metastasis: A Rare Initial Presentation of Prostate Carcinoma (original) (raw)
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Solitary brain metastasis from prostate cancer: a case report
Annals of palliative medicine, 2016
Brain metastases arising from prostate cancer are exceedingly rare and typically occur late in the course of the disease. Most patients have widespread metastatic disease before developing brain metastases from prostate cancer. We report the case of a 67-year-old male with prostate cancer presenting with an isolated symptomatic brain metastasis. Aggressive treatment of the metastatic site included tumor resection and adjuvant stereotactic radiation treatment (RT) to the surgical bed, resulting in a favorable outcome.
2021
Prostate cancer is the most common cancer and among the leading causes of cancer death in men and its clinical symptoms vary a lot. The most common metastatic site is the bones, but rarely prostate cancer can metastasize to brain in very advanced stages of the disease. However, brain metastases giving neurological symptoms as first manifestation of prostate cancers have been reported. Research of international literature revealed only seventeen patients (including our own) that were diagnosed with prostate cancer presented with neurological symptoms.
Brain Metastasis From Prostate Adenocarcinoma: Case Report and Review of Literature
World Journal of Oncology, 2012
It is rare for prostate carcinoma to metastasize to the central nervous system. It often represents a terminal event with death in one year frequently due to the advanced systemic disease. Starting by a case report, we also reviewed the relevant literature to focus on this uncommon entity from epidemiology to clinical manifestation and therapeutic strategies. In this article, a case of multiple brain prostate metastasis is reported and a review of relevant literature is also discussed. Treatments available for intracranial metastasis include neurosurgery, external beam radiation and hormonal manipulation. Surgery associated with whole brain radiotherapy seems to be effective in the control of brain lesions both relieving neurological symptoms and prolonging survival, even if prognosis remains dismal. From this case, we concluded that brain metastasis from prostate carcinoma is a rare, terminal event with death in one year frequently due to the advanced systemic disease. A better understanding of the biology of prostate carcinoma will help clarify the basis for its metastasis to the brain.
Brain metastases from prostate cancer: A single-center experience
Turkish journal of urology, 2018
Metastases from prostate cancer to the brain are very unusual and very few case series have been reported in the literature. Present study was performed to assess the proportion of brain metastasis from prostate cancer among other brain metastasis in men, to evaluate the distribution, pattern and magnetic resonance imaging (MRI) appearance of these metastatic lesions, and prognosis of brain metastasis in patients with prostate cancer. Between January 2010 and November 2016, 339 males who had received radiotherapy at our department were retrospectively reviewed. After the first evaluation of patients data, we reviewed only the patients with brain metastases from prostate cancer. We evaluated MRI characteristics of metastatic brain lesions and characteristics of the patients, tumor and treatment modalities. Ten of 339 patients (2.9%) had brain metastases from prostate cancer. Sixty percent of the patients had pure intraparenchymal metastasis, 20% of the patients had pure extensive dur...
Brain metastasis from prostate carcinoma: Antemortem recognition and outcome after treatment
Cancer, 1999
Brain Metastasis from Prostate Carcinoma Antemortem Recognition and Outcome after Treatment W e read with interest the article on brain metastasis from prostate carcinoma (CaP) by McCutcheon et al. 1 published in Cancer. For the benefit of the readers, we would like to update and refine the data regarding solitary brain metastasis from CaP. Using the MEDLINE database, we reviewed the data concerning brain metastasis and prostate carcinoma in living patients from 1960 to 1999. We excluded patients who lacked a negative metastatic survey and a brain biopsy consistent with CaP. We found a total of eight patients who met our criteria. Sites of single metastasis included pons alone (one patient), pons at the cerebellar-pontine angle (one patient), pons and cerebral peduncle (one patient), pons and cerebellar peduncle (one patient), pons and midbrain (one patient), the parietal lobe (one patient), the temporal lobe (one patient), and the frontoparietal lobe (one patient). Brain biopsy yielded seven patients with CaP and one patient with papillary adenocarcinoma. Brain histology included poorly differentiated (two patients), moderately differentiated (one patient), and well differentiated (four patients) CaP. The rate of incidence of brain metastasis from CaP in the recent study by McCutcheon et al. was 0.7%. 1 One study proposes four reasons for the low incidence rate of clinically suspect solitary brain metastasis from CaP: 1) lower detection rate of tumor spread to brain (even in autopsy data), 2) late occurrence of brain involvement in the course of the disease, 3) clinically silent growth related to the most common site of tumor involvement, and 4) rare and nonspecific symptoms due to brain metastasis from CaP. 2,3 Another hypothesis for the rarity of solitary brain metastases in patients with CaP is that the brain parenchyma does not represent "fertile soil" for CaP cells, just as, conversely, the skeleton provides a preferential milieu for these cells. 4 We believe our review shows the highest percentage of prostate metastasis to the pons Ϯ cerebrum, cerebellum, and midbrain reported to date. McCutcheon et al.'s large series included only three patients who had metastatic disease solely to the brain. One patient had metastases specifically to the hypothalamus and the right temporal lobe. The other two patients had multiple frontal metastases. Their review also included seven additional patients who presented with a solitary brain metastasis. To our knowledge the study by Gupta et al. was the only analysis that met the criteria for our study. 5 The number of solitary brain metastasis from CaP may indeed be higher than previously thought. McCutcheon et al. were correct to speculate that given the obscuring effect of bone artifact in the posterior fossa on computed tomography (CT) scans of the brain, tumor in this location actually may be underreported when CT is the primary method used. The fact that magnetic resonance imaging diagnosed all the patients with a solitary brain metastasis to the pons lends support to their theory.
Brain metastasis from prostate carcinoma
Cancer, 1999
BACKGROUND. In patients with prostate carcinoma, brain metastasis has most commonly been reported in autopsy series. Symptomatic brain metastasis from prostate carcinoma has occasionally been detected.
Metastatic Prostate Adenocarcinoma to the Brain: Case Reports and Literature Review
Journal of Neurological Surgery Reports
Cerebral metastasis secondary to prostatic adenocarcinoma is rare and it is usually a late complication in patients with widespread distant metastases. Here, we report two unusual cases of such a rare condition. Our first case presented with a large frontal contrast-enhancing lesion-associated calcification and a large tumor cyst as shown on computed tomography and magnetic resonance imaging. This is the fifth reported case of prostatic metastasis manifesting as a cystic intraparenchymal tumor in the literature. The second case presented with a large soft tissue mass in the scalp and this lesion appeared to invade through the skull and into the middle cranial fossa. He was not known to have prostate cancer before his initial presentation and it was only diagnosed following histology results of the scalp lesion.
Prostate Cancer
Aim. Prostate cancer (PCa) is the second most common nonskin malignancy and the second most common cause of cancer-related deaths in men. The most common site of metastasis in PCa is the axial skeleton which may lead to back pain or pathological fractures. Hematogenous spread to the brain and involvement of the central nervous system (CNS) are a rare occurrence. However, failed androgen deprivation therapy (ADT) may facilitate such a spread resulting in an advanced metastatic stage of PCa, which carries a poor prognosis. Methods. In this systematic review, we searched the PubMed, Scopus, and Web of Science online databases based on the PRISMA guideline and used all the medical subject headings (MeSH) in terms of the following search line: (“Brain Neoplasms” OR “Central Nervous System Neoplasms”) and (“Prostatic Neoplasms” OR “Prostate”). Related studies were identified and reviewed. Results. A total of 59 eligible studies (902 patients) were included in this systematic review. In or...
Brain metastasis from prostate small cell carcinoma: not to be neglected
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2002
Symptomatic brain metastases from prostatic carcinoma are rare (0.05% to 0.5%). A 70-year-old man presented with a homonymous hemianopsia due to brain metastatic prostatic carcinoma shortly before becoming symptomatic of prostatic disease. CT and MRI of the brain showed a tumour deep in the right hemisphere near the thalamus and involving the optic radiation. Routine haematological and biochemical tests were normal. The prostate specific antigen level was low on two separate occasions. The prostatic and brain tumours showed identical appearances, namely of a poorly differentiated adenocarcinoma with neuroendocrine differentiation (small cell carcinoma). A literature review suggests that small cell carcinoma of the prostate is more likely to spread to the brain compared to adenocarcinoma and that brain metastases indicate a poor prognosis. The prostate gland should be remembered as a possible cause of brain metastases and that a normal serum prostate specific antigen does not exclude...
Brain stem metastasis as the only site of spread in prostate carcinoma. A case report
Cancer, 1994
Metastasis to the brain from prostate carcinoma is a rare event, having been reported in less than 5% of postmortem examinations. The incidence of cases detected antemortem is even smaller, and the incidence of brain metastasis as the only site of metastasis has been reported in only one other case. The authors present a second such case of a patient with a Stage C adenocarcinoma of the prostate that metastasized to the brain stem; this was the only site of spread. Cancer 1994;74:2516-9.