Health Risk Assessment for Diabetes Mellitus Based on Longitudinal Analysis of MHTS Database (original) (raw)
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PLOS ONE, 2015
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Risk Assessment of Type 2 Diabetes Mellitus in the Population of Chonburi, Thailand
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This study aims to develop a risk score to identify people at high risk for type 2 diabetes mellitus (T2DM) in the population of Chonburi, Thailand, and to compare this risk score with 2 previous predictive risk scores for T2DM. Data from 7,284 individuals aged ≥ 20 years were collected from the Thai population, using a cross-sectional analytical study method. A screening algorithm was developed based on the first half and validated in the second half of the study population. Logistic regression analysis was used to determine the risk factors for T2DM, by performing a predictive model in which only significant factors were included. Afterwards, our predictive model was compared with the other 2 predictive models, where risk scores were derived from Thai adults. Our results showed that significant predictive variables were age, BMI, hypertension, history of diabetes in parents or siblings, and marital status. A cutoff score of 9 out of 17 produced the optimal sums of sensitivity (74 ...
A Competing Risk Hazard Model for Complications of Diabetes Mellitus
Journal of Biosciences and Medicines, 2014
In recent years, non-communicable diseases (NCD) like obesity, hypertension (HTN) and Type2 diabetes (T2DM) are on the increase, specially in the developing nations. Body mass index (BMI), waist-to-hip ratio (WHR) and Waist-to-height ratio (WHtR) are used as indices of obesity to relate T2DM, HTN and coronary artery disease (CAD). This study addresses whether the risk of obesity for HTN differs between T2DM and non-DM subjects. We investigated 693 diabetic patients from BIRDEM and 2384 from communities. We measured height, weight, waist-girth, hip-girth and blood pressure. All subjects underwent oral glucose tolerance test (OGTT). BMI, WHR and WHtR were calculated. Systolic and diastolic hypertension (sHTN and dHTN)) were defined as SBP >=140 and DBP >= 90 mmHg, respectively. The prevalence of both sHTN and dHTN in T2DM was higher than the non-DM subjects (sHTN: 49.1 vs 14.3%, dHTN 19.6 vs. 9.5%). The comparison of characteristics between subjects with and without hypertension showed that the differences were significant for age, weight, waist-girth, BMI, WHR and WHtR for both T2DM and non-DM subjects (for all p<0.001). The increasing trend of hypertension with increasing obesity was observed more in the non-DM than in the T2DM subjects. The risk (OR) of obesity for hypertension increased with increasing WHR and WHtR in the non-DM than the T2DM subjects. Compared with the non-DM the T2DM participants had two to three folds higher prevalence of HTN. In either group, BMI, WHR and WHtR were significantly higher in the hypertensive than the non-hypertensive subjects. The prevalence of hypertension increased with the increasing BMI, WHR and WHtR but significant only in the non-DM. Further studies may confirm these findings and determine whether there was any altered association between blood pressure and obesity in diabetes possibily, with or without autonomic neuropathy.
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Abstract proceedings international scholars conference, 2016
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BMJ open, 2015
To examine the association between diabetes and premature death for Japanese general people. Prospective cohort study. The Japan Public Health Center-based prospective study (JPHC study), data collected between 1990 and 2010. A total of 46 017 men and 53 567 women, aged 40-69 years at the beginning of baseline survey. Overall and cause specific mortality. Cox proportional hazards models were used to calculate the HRs of all cause and cause specific mortality associated with diabetes. The median follow-up period was 17.8 years. During the follow-up period, 8223 men and 4640 women have died. Diabetes was associated with increased risk of death (856 men and 345 women; HR 1.60, (95% CI 1.49 to 1.71) for men and 1.98 (95% CI 1.77 to 2.21) for women). As for the cause of death, diabetes was associated with increased risk of death by circulatory diseases (HR 1.76 (95% CI 1.53 to 2.02) for men and 2.49 (95% CI 2.06 to 3.01) for women) while its association with the risk of cancer death was ...