Topical Vitamin E Acetate for the Treatment of Cheilitis: A Multicentre Experience (original) (raw)
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Characterization and management of exfoliative cheilitis: a single-center experience
Oral surgery, oral medicine, oral pathology and oral radiology, 2013
Exfoliative cheilitis (EC) is a rare inflammatory condition affecting the vermilion of the lips and characterized by production of a thick keratin scale. Given the limited available data, the approach to optimal management of EC remains unclear. The objective of this retrospective study was to characterize the clinical features, management, and outcomes of a series of patients with EC. Fifteen patients with a median age of 59 years and a female-to-male ratio of 2:1 were diagnosed with EC from 2000 to 2010. Parafunctional lip licking (53%) and a history of psychiatric disorders (40%) were common. Ten patients (66%) returned for follow-up, with an overall response rate (partial or complete) of 80% at a median of 2 months, most frequently associated with the use of topical calcineurin inhibitors or moisturizing agents. Management of EC with topical calcineurin inhibitors and moisturizing agents is associated with clinical improvement, but prospective trials are needed.
Journal of Clinical and Experimental Dentistry, 2020
Background Actinic Cheilitis (AC) is a pathological condition of the labial mucosa considered potentially malignant. The aim of this study was to investigate the effect of treatment of AC with daily use of a vitamin-based barrier cream. Material and Methods For this clinical study, 36 participants with lower-lip AC were recruited from three oral medicine services. At baseline, participants were evaluated by clinical examination and clinical severity of AC was classified as grade I to IV. All participants were dispensed a tube of a barrier cream containing vitamins A, D, E and ZnO to apply once nightly for 90 consecutive days. Monthly follow-up was performed to reclassify AC clinial severity. The primary outcome of interest was clinical remission of AC at 90-day follow-up compared to baseline. Results Progressive remission of AC lesions was observed as early as the first month and throughout the assessment period (p = 0.000). The 3-month period was insufficient for remission of lesio...
Isolated lip dermatitis (atopic cheilitis), successfully treated with topical tacrolimus 0.03%
Medicina Oral Patología Oral y Cirugia Bucal, 2021
Background: Exfoliative and erosive cheilitis, may be a source of speech and chewing discomfort, but may also be an aesthetic issue for the patients affected. Such a clinical presentation may implicate a variety of inflammatory conditions, including atopic (eczematous) cheilitis. Topical and systemic agents, e.g. corticosteroids, have been used to treat inflammatory lip conditions. Topical tacrolimus has also been used in some inflammatory lip conditions. Material and Methods: We performed a retrospective clinical analysis of atopic cheilitis patients. Results: Between 2015 and 2020, we addressed 7 (seven) patients with atopic dermatitis affecting only lips and were diagnosed as atopic-eczematous cheilitis. They were treated with 0.03 per cent topical tacrolimus ointment and responded completely. Conclusions: These cases represent an underreported atopy / eczema event;-few cases of atopic cheilitis without concomitant dermal lesions appear in the literature. We are also showing and discussing yet another application of tacrolimus in a local atopic form of inflammation affecting the lips.
Exfoliative Cheilitis a male patient – a case report
Introduction: Exfoliative cheilitis, one of a spectrum of diseases that affect the vermilion border of the lips, is uncommon and has no known cause. It is a chronic superficial inflammatory disorder of the vermilion borders of the lips characterized by persistent scaling; it can be a difficult condition to manage. The diagnosis is now restricted to those few patients whose lesions cannot be attributed to other causes, such as contact sensitization or light. Case Report: We present a 17 year-old male presented to the out clinic in Baghdad with the chief complaint of a persistent scaly on his lower lips. The patient reported that the skin over the lip thickened gradually over a 3 days period and subsequently became loose, causing discomfort. Once he peeled away the loosened layer, a new layer began to form again. Conclusion: The lack of specific treatment makes exfoliative cheilitis a chronic disease that radically affects a person’s life. The aim of this paper is to describe a case of recurrent exfoliative cheilitis successfully treated with intralesional corticosteroids and to present possible hypotheses as to the cause.
Exfoliative Cheilitis: Report of a Case
Exfoliative cheilitis, one of a spectrum of diseases that affect the vermilion border of the lips, is uncommon and has no known cause. However, factors such as stress and some psychiatric conditions are associated with the onset of the disease. This condition is disabling because esthetics and normal functions such as eating, speaking and smiling are compromised. The lack of specific treatment makes exfoliative cheilitis a chronic disease that radically affects a person's life. This report attempts to further investigate the clinical course of the disease and provides detailed illustrations of the cyclical nature of the disease. For citation purposes, the electronic version is the definitive version of this article:
Vitamin E does not reduce the side-effects of isotretinoin in the treatment of acne vulgaris
International journal of dermatology, 2005
Isotretinoin is widely used in the treatment of severe, recalcitrant, nodular acne. Mucocutaneous side-effects are seen in the great majority of patients and some of them have elevations in their serum lipid and liver enzyme profiles. Recently, it has been shown that addition of vitamin E decreased the toxicity of high-dose retinoids. The purpose of this investigator-blinded, randomized study was to assess whether vitamin E would reduce the side-effects of isotretinoin in the treatment of acne vulgaris. Eighty two patients were randomly assigned to one of two treatment groups with isotretinoin (1 mg/kg/day) alone or combined with vitamin E (800 IU/day). The treatment duration was 16 weeks. Mucocutaneous side-effects such as facial erythema, facial dryness, cheilitis and serum lipid and liver enzyme profiles were assessed. There was no difference in the incidence and severity of side-effects related to isotretinoin between the two treatment groups. Eight hundred IU/day vitamin E did ...
Vitamin E in Atopic Dermatitis: From Preclinical to Clinical Studies
Dermatology
Background: Oxidative stress and inflammation are some of the proposed mechanisms involved in the pathogenesis of atopic dermatitis (AD). Current pharmacotherapeutic approaches are effective yet they are not without adverse effects. Vitamin E has great potential as an adjunctive treatment for AD owing to its antioxidant and anti-inflammatory bioactivities. Summary: This review article summarizes the current available evidence from cellular, animal and clinical studies on the relationship between vitamin E and AD. The future prospects of vitamin E are also discussed. Vitamin E in practice does not show any toxicity to humans within a range of reasonable dosage. Albeit rarely, vitamin E as a contact allergen should be considered. Collectively, this review envisaged vitamin E as an adjunctive treatment for AD patients. Future research on the distinct effects of different vitamin E isoforms as well as their delivery system in skin disorders is needed.
Acta Dermatovenerologica Alpina Pannonica et Adriatica, 2020
Currently, there are no clear recommendations for diagnostic management of lip inflammation and cheilitis, which is evident in the varied nomenclature and subtypes found in medical literature on cheilitis. This can confound diagnostic management. We therefore recently put forth a proposal for cheilitis classification, defining three groups of cheilitis based on duration and etiology: mainly reversible cheilitis, mainly irreversible cheilitis, and cheilitis connected to other diseases. The most common forms of cheilitis are the reversible types, usually of short duration and commonly easily resolved or treated. In contrast, irreversible types of cheilitis are rare, are harder to treat, and are confirmed only after a biopsy of an inflamed lesion. To correctly diagnose and manage the different types, practitioners must consider several factors, including visible manifestations of the disease, related diseases and symptoms, personal habits, weather conditions, allergies, nutritional deficiencies, and results from tissue swabs and biopsies. In addition, multispecialty collaboration and communication involving dermatology, oral pathology, clinical immunology, otorhinolaryngology, rheumatology, and other fields can be crucial for patient outcome. We believe our classification system would be of great benefit to researchers, patients, and doctors by simplifying both nomenclature and disease recognition, thus ensuring timely and adequate treatment.