Formulation , characterization and drug release kinetics of floating drug delivery systems (original) (raw)
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A REVIEW ON CONTROLLED RELEASE FLOATING DRUG DELIVERY SYSTEMS IN PHARMACEUTICAL FORMULATIONS
EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH, 2019
Over the years there has been available a variety of drug modification and dosage forms, with which we have attempted to control the time course and specificity of drugs in the body maximize drug utilization, it is necessary to deliver the drug to its target tissue in the correct amount at the proper time to elicit the desired response. The most convenient method of controlled delivery of drug is undoubtedly oral, but oral controlled release of the drug for an extended period of time that exhibits more absorption in stomach and upper small intestine, has not been successful with conventional approaches. Consequently, most research efforts have been focused on platforms to extend gastric residence time (GRT) of these drugs. The novel design of Oral Controlled Drug Delivery System(OCDDS) should be primarily aimed at achieving a more predictable and increased bioavailability of drugs. However, the development process is precluded by several physiological difficulties, such as inability to restrain and localize controlled drug delivery systems (CDDS) within the desired regions of the gastrointestinal (GI) tract and highly variable nature of the gastric emptying process. Thus, conventional OCDDS has not been suitable for a variety of important drugs which has any of above mentioned characteristics, which is mainly due to the relatively short transit time of the dosage form in the stomach and upper part of small intestine. The overall results are accompanied by lesser bioavailability. Furthermore, the relatively brief gastric emptying time in humans, which normally range from 2 - 3 hours through the major absorption zone (stomach or upper part of intestine), can result in incomplete drug release from the dosage form leading to diminished efficacy of the administered dose. Thus, control of placement of drug delivery system in a specific region of the GI tract offers numerous advantages. From the formulation and technological point of view, the Floating Drug Delivery System (FDDS) is considerably an easy and logical approach in the development of gastro retentive dosage forms. Hence in the present study, the formulation of Gastro Retentive Dosage Forms (GRDFs) is done by FDDS.
A Review on the Floating Drug Delivery System -Its Evaluations and Recent Works Done in 4-5 Years
International Journal of Pharmaceutical Sciences Review and Research, 2024
Since floating drug delivery systems may solve the disadvantages associated with traditional drug delivery systems, such as frequent dosing, limited bioavailability, etc., in comparison to quick stomach emptying time, they have attracted a lot of attention in recent decades. A system that stays in the stomach for an adequate amount of time and delivers the active medication continuously is known as an ideal floating drug delivery system. These continue to float over the stomach contents. prolonging the pharmacological effects and enhancing the drug's bioavailability. This overview of gastroretentive and floating tablets was written to gather recent research on the topic, as well as information on the floating tablets' principles, benefits, categorization, preparation, and assessment methods, and a list of medications that have been developed as floating tablets. formulation evaluation and future scope of floating tablets. The review concentrated on the types of floating medication delivery systems and the formulation aspect of effervescent floating drug delivery systems. The review's objective is to gather the research being done on this floating medicine delivery device. The review addresses several aspects that impact stomach retention (long duration) and offers useful information about the pharmaceutical formulation side of it.
Floating Drug Delivery System: An Overview
sphinxsai.com
Floating drug delivery systems (FDDS) was to organize the recently focus on the principalmechanism of floatation to achieve gastric retention time. The recent developments of FDDS including thephysiological and formulation variables affecting gastric retention, approaches to design floating systems, and their classification and formulation aspects are covered in detail. Gastric emptying ofdosage forms is an extremely variable process and ability to prolong and control the gastric emptying time is a valuable asset for dosage forms, which reside in the stomach for a longer period of time than conventional dosage forms. Gastroretentive systems can remain in the gastric region for several hours for significantly prolong residence time of drugs by which improves bioavailability, reduces drug waste, and improves solubility for drugs that are less soluble in a high pH environment.. The present review addresses briefly about the floating drug delivery systems.
Floating drug delivery systems: A review
Aaps Pharmscitech, 2005
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.
2011
Controlled release (CR) dosage forms have been extensively used to improve therapy with many important drugs. Several approaches are currently utilized in prolongation of gastric residence time, including floating drug delivery system, swelling and expanding system, polymeric bioadhesive system, modified shape system, high density system and other delayed gastric emptying devices. However, the development processes are faced with several physiological difficulties such as the inability to restrain and localize the system within the desired region of the gastrointestinal tract and the highly variable nature of the gastric emptying process. On the other hand, incorporation of the drug in a controlled release gastroretentive dosage forms (CR-GRDF) which can remain in the gastric region for several hours would significantly prolong the gastric residence time of drugs and improve bioavailability, reduce drug waste, and enhance the solubility of drugs that are less soluble in high pH environment. Gastroretention would also facilitate local drug delivery to the stomach and proximal small intestine. Thus, gastroretention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits to patients. The purpose of this paper is to review the recent literature and current technology used in the development of gastroretentive dosage forms.
CRITICAL REVIEW IN PHARMACEUTICAL SCIENCES A REVIEW: FLOATING DRUG DELIVERY SYSTEM (FDDS
Current pharmaceutical scenario focuses on the formulation of floating drug delivery system (FDDS). Floating drug delivery systems are low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. They provide an efficient means for improving the drug bioavailability; reducing drug wastage and better patient compliance by increasing the gastric residence time and provide controlled drug delivery. The gastric emptying of a dosage form is a complex process and one of the biggest hindrance in the better absorption and increases bioavailability of oral drug delivery system. Floating drug delivery systems (FDDS) are a convenient approach to overcome this variability by increasing the gastric retention time of the drug delivery systems. FDDS are of great interest for drugs that are locally active and narrow absorption window in stomach or upper small intestine, unstable in the intestinal environment and also exhibit low solubility at high pH values. The aim of writing this review on floating drug delivery systems is to compile the current literature with important focus on the principal mechanism of floatation to attain gastric retention. The review briefly describes the floating mechanism, types of floating system, advantages, limitation, factors affecting floating system, drug candidates suitable for floating, evaluation parameters and application of the system.
A Overview on Study of Floating Drug Delivery Systems
Gastro-retentive floating drug delivery systems have emerged as an efficient means of enhancing the bioavailability and controlled delivery of many drugs. The controlled gastric retention of solid dosage forms may be achieved by the mechanisms of mucoadhesion, flotation, sedimentation, expansion, modified shape systems, or by the simultaneous administration of pharmacological agents that delay gastric emptying. Based on these approaches, classification of floating drug delivery systems (FDDS) has been described in detail. In vivo/in vitro evaluation of FDDS has been discussed by scientists to assess the efficiency and application of such systems. Several recent examples have been reported showing the efficiency of such systems for drugs with bioavailability problems.
FLOATING DRUG DELIVERY SYSTEMS: RATIONALE FOR DRUG SELECTION
In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying time (GET). Several approaches are currently utilized in the prolongation of the GRT. In this review, the current technological developments of FDDS including their drug of choice to be formulated and future potential for oral controlled drug delivery are discussed. The main motto of writing this review article is to compile the information regarding the criteria of drug selection for the floating drug delivery system. In this present review various attempt was made for the discussion of the nature of drug to be selected while formulating floating drug delivery system. Numerous properties of the drug and their mechanism of reaction with polymers was compiled for this study. The various properties of drug such as Biopharmaceutical classification system, Solubility in acidic medium, Partition coefficient, Dissociation constant, Half life, Hepatic clearance, Absorption window, First pass metabolism, Acidic stability, Hydrolysis, Crystallinity of drug, Hydrates form of drug, Irritancy of drug, GI motility, Non Emetic are taken into consideration . With contrast to the various properties of drug molecule, their utilization in the floating drug delivery system is point of concern. The various properties and nature of drug tends to produce an eventual and effective drug delivery system, so that one can understand the basic information for formulating floating drug delivery system.
Glimpse of Comprehensive Review on Floating Drug Delivery System’: A Global perception
The oral route is considered as the most promising route of drug the delivery of therapeutic agents because the low cost of the therapy and ease of administration which lead to high levels of patient compliance and still the preferred route of drug administration. systems available in the market are oral drug delivery systems gastrointestinal tract but eliminated quickly from the blood circulation, an incomplete release of the drug and shorter residence time of the dosage form, will lead to lower bioavailability several drug delivery systems with prolonged gastric retention time have been investigated. Attempts are being made to develop a controlled drug Floating Drug delivery system is designed to prolong the gastric residence time after oral administration, at a particular site and improving bioavailability. The idea of gastric retention comes from the need to localize drugs at a specific region of gastrointestinal tract (GIT) such as stomach in the body. The drugs which are poorly soluble in intestine due to alkaline pH; gastric retention may increase solubility before they are emptied. Floating dosage form can be prepared as tablets, capsules by adding generating agents. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDs), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified delayed gastric emptying devices. This review also summarizes the evaluate the performance and application of floating systems.
A Review On: Gastroretentive Floating Drug Delivery System
2019
Technological attempts have been made in the research and development of rate-controlled oral drug delivery systems to overcome physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). It is known that differences in gastric physiology, such as, gastric pH, and motility exhibit both intra-as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behaviour. This triggered the attention towards formulation of stomach specific (gastro retentive) dosage forms. This dosage forms will be very much useful to deliver 'narrow absorption window' drugs. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. In this review, current & recent developments of Stomach Specific FDDS are discussed.