Confirmation of linkage between juvenile myoclonic epilepsy locus and the HLA region of chromosome 6 (original) (raw)

1991, American Journal of Medical Genetics

AI-generated Abstract

This study re-examines the linkage between juvenile myoclonic epilepsy (JME) and the HLA region of chromosome 6, confirming the association while reporting a larger recombination fraction than previously indicated. Using data from 23 families, various inheritance models were tested, yielding a maximum lod score of 3.11 under an autosomal dominant model, supporting the hypothesis that JME has a genetic component linked to the HLA region.