Codon-optimized TDP-43-mediated neurodegeneration in a Drosophila model for ALS/FTLD
Shreyasi Chatterjee
2019
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Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
Andrea D'Ambrogio
FEBS Letters, 2009
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Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
Nabanita Chatterjee
PLoS genetics, 2017
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Modelling dementia in Drosophila uncovers shared and specific targets of TDP-43 proteinopathy across ALS and FTD relevant circuits
Allison Michael
bioRxiv (Cold Spring Harbor Laboratory), 2022
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Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders
Christine Van Broeckhoven
Human Molecular Genetics, 2013
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The role of TDP-43 in the pathogenesis of ALS and FTLD
Emanuele Buratti
2013
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Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes
Ben Sutcliffe
Human Molecular Genetics, 2013
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Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats
Cao Huang
Journal of Clinical Investigation, 2012
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Altered TDP-43 Structure and Function: Key Insights into Aberrant RNA, Mitochondrial, and Cellular and Systemic Metabolism in Amyotrophic Lateral Sclerosis
Leanne Jiang
Metabolites
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Drosophila Answers to TDP-43 Proteinopathies
Emanuele Buratti
2012
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A Computational Approach to Investigate TDP-43 RNA-Recognition Motif 2 C-Terminal Fragments Aggregation in Amyotrophic Lateral Sclerosis
Elsa Zacco
Biomolecules, 2021
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Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis
Leonardo J. Moya Aliaga
Proceedings of the National Academy of Sciences, 2014
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Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS
Kazuhide Asakawa
Cellular and Molecular Life Sciences
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TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS
Ernesto Manzo
Metabolites, 2022
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The Impact of ALS-Associated Genes hnRNPA1, MATR3, VCP and UBQLN2 on the Severity of TDP-43 Aggregation
Helena Motaln
Cells, 2020
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Overexpression of ALS-Associated p.M337V Human TDP-43 in Mice Worsens Disease Features Compared to Wild-type Human TDP-43 Mice
Christine Van Broeckhoven
Molecular Neurobiology, 2013
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Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
Travis Unger
Journal of Clinical Investigation, 2011
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Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth
Christine Van Broeckhoven
Proceedings of the National Academy of Sciences, 2013
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{"__content__"=>"Robustness and Vulnerability of the Autoregulatory System That Maintains Nuclear TDP-43 Levels: A Trade-off Hypothesis for ALS Pathology Based on Data.", "i"=>{"__content__"=>"in Silico"}}
Osamu Onodera
Frontiers in neuroscience, 2018
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Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
Edward Chaum, Nael H Alami
Neuron, 2014
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Atypical TDP ‐43 protein expression in an ALS pedigree carrying a p. Y374X truncation mutation in TARDBP
Janine Kirby
Brain Pathology, 2022
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Wild type human TDP-43 potentiates ALS- linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS
耀翔 施
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TDP-43 proteinopathies: a new wave of neurodegenerative diseases
Parvathi Menon
Journal of Neurology, Neurosurgery & Psychiatry
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Cell environment shapes TDP-43 function with implications in neuronal and muscle disease
Emanuele Buratti
Communications Biology
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Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death
Lorne Zinman
Acta neuropathologica, 2015
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Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
Magdalini Polymenidou
Nature Neuroscience, 2012
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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
Claudio Albuquerque
Proceedings of the National Academy of Sciences, 2010
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TDP-43 and Cytoskeletal Proteins in ALS
Max Holzer
Molecular Neurobiology, 2017
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Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS
André Bongers, Nikolas Haass
Acta neuropathologica, 2015
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What is the key player in TDP-43 pathology in ALS: Disappearance from the nucleus or inclusion formation in the cytoplasm?
Osamu Onodera
Neurology and Clinical Neuroscience, 2013
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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
Christine Van Broeckhoven
Proceedings of the National Academy of Sciences, 2010
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