Low level light effects on inflammatory cytokine production by rheumatoid arthritis synoviocytes (original) (raw)
2009, Lasers in Surgery and Medicine
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Role of LIGHT in the pathogenesis of joint destruction in rheumatoid arthritis
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Institutional review board statement: All synovial studies and synovial fluid samples were taken from patients after informed consent and ethical permission was obtained for participation in this study. The research Ethics were granted by National Research Ethics Committee (Oxfordshire), REC reference number C01.070. Institutional animal care and use committee statement: Not applicable.
Immunology, 2005
Macrophages play a crucial role in the perpetuation of inflammation and irreversible cartilage damage during the development of rheumatoid arthritis (RA). LIGHT (TNFSF14) and its receptor TR2 (TNFRSF14) are known to have pro-inflammatory activities in foam cells of atherosclerotic plaques. We tested a hypothesis that LIGHT and TR2 are involved in activation of monocyte/macrophages in RA synovium. Immunohistochemical analysis of RA synovial tissue samples revealed that both LIGHT and TR2 are expressed in CD68 positive macrophages. In contrast, synovial tissue samples from osteoarthritis (OA) patients failed to reveal the expression of LIGHT. Expression of TR2 in RA synovial macrophages was also detected using flow cytometry analysis. To identify the role of LIGHT in the functioning of macrophages in RA, we isolated macrophage enriched cells from RA synovial fluid and stimulated them with LIGHT. LIGHT induced expression of matrix metalloproteinase-9 and pro-inflammatory cytokines such as tumor necrosis factor (TNF)-a, interleukin (IL)-6, and IL-8. These data indicate that LIGHT and TR2 expressed in macrophages are involved in the pathogenesis of RA by inducing the expression pro-inflammatory cytokines and matrix degrading enzymes.
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