Fab on a Package: LTCC Microfluidic Devices Applied to Chemical Process Miniaturization (original) (raw)
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Journal of Microelectronics and Electronic Packaging, 2013
Miniaturization of chemical processes is becoming a must for green chemistry and sustainable industry processes, so technological research in this direction is well received. Continuous microreactor systems hold many potential benefits over batch reactors, in that they allow: high surface-to-volume ratio, fine adjustment of chemical reaction residence times, small thermal inertia, and fast changes in temperature. Advantages of multilayer green ceramics for microprocess applications include: that the LTCC substrate is chemically inert to most solvents, that it has a high contact angle, that it presents low thermal coefficient of expansion, and that it can withstand high operational temperatures and high internal pressures. For these reasons, LTCC-based microsystem technologies allow the implementation of different unitary operations for chemical processes, making it an enabling technology for the miniaturization of chemical processes. In fact, recently, LTCC microfluidic reactors hav...
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A microfluidic system based on the low-temperature co-fired ceramics technology (LTCC) is proposed to reproducibly carry out a simple one-phase synthesis and functionalization of monodispersed gold nanoparticles. It takes advantage of the LTCC technology, offering a fast prototyping without the need to use sophisticated facilities, reducing significantly the cost and production time of microfluidic systems. Some other interesting advantages of the ceramic materials compared to glass, silicon or polymers are their versatility and chemical resistivity. The technology enables the construction of multilayered systems, which can integrate other mechanical, electronic and fluidic components in a single substrate. This approach allows rapid, easy, low cost and automated synthesis of the gold colloidal, thus it becomes a useful approach in the progression from laboratory scale to pilot-line scale processes, which is currently demanded.
LTCC-3D Flow Focusing Fluidic Microreactor for Nanoparticle Fabrication and Production Scale-Out
Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT), 2013
Miniaturization of chemical processes is becoming a must for green chemistry and sustainable industry processes, so technological research in this direction is well received. Continuous microreactor systems hold many potential benefits over batch reactors allowing: high surface-to-volume ratio, fine adjustment of chemical reaction residence times, small thermal inertia and fast changes in temperature. Advantages of multilayer green ceramics for microprocess applications include: LTCC substrate is chemically inert to most solvents, it has a high contact angle, presents low thermal coefficient of expansion, can withstand high operational temperatures and high internal pressures. For these reasons, LTCC-based microsystem technologies allow the implementation of different unitary operations for chemical process, making it an enabling technology for the miniaturization of chemical processes. In fact, recently LTCC microfluidic reactors have been used to produce micro and nanoparticles wi...
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By miniaturizing the reactor dimension, microfluidic devices are attracting world attention and starting the microfluidic era, especially in the chemistry field because they offer great advantages such as rapid processes, small amount of the required reagents, low risk, ease and accurate control, portable and possibility of online monitoring. Because of that, microfluidic devices have been massively investigated and applied for the real application of human life. This review summarizes the up-to-date microfluidic research works including continuous-flow, droplet-based, open-system, paper-based and digital microfluidic devices. The brief fabrication technique of those microfluidic devices, as well as their potential application for particles separation, solvent extraction, nanoparticle fabrication, qualitative and quantitative analysis, environmental monitoring, drug delivery, biochemical assay and so on, are discussed. Recent perspectives of the microfluidics as a lab-on-chip or mic...
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This research aims to develop a microfluidic system for chemical process miniaturization for nanocapsules generation. The emulsification, diffusion and solvent extraction/evaporation process was selected as target for miniaturization. LTCC was the selected substrate. Experiments showed the viability of controlling nanocapsules sizing by means of total flow rate through devices. Generated nanocapsules size varied between 790,5 nm ± 36,9 nm and 209,7 nm ± 3,5 nm with a polydispersity index (pdi) between 0,313 ± 0,016 and 0,09 ± 0,017 when flow rate varied between 90 mL/min and 293 mL/min. Other experiments were carried out up to 323 mL/min obtaining nanocapsules sizes down to 193 nm and pdi of 0,109. The flow rate working region is an order of magnitude higher than reported devices which bases its functioning in micromixers. Research results show the developed system potentiality in reducing the existing gap between laboratory and chemical process industry for microfluidic devices. Ke...
Additional Conferences (Device Packaging, HiTEC, HiTEN, and CICMT), 2015
Nanotechnology develops methods and processes for Drug Delivery Systems (DDS) based on the fabrication of polymeric nano/microparticles with encapsulated drug that can be applied for maximize therapeutic activity and minimizes undesirable effects. However, these processes entail several conditions to operate efficiently. They present high sensibility to changes in temperature, flow rate, pressure, and chemical solution composition. An optimal configuration of these parameters is required to guarantee stable particle production. For these reasons, integration of technological devices like sensors, actuators, microfluidic devices and control systems is essential to increase particle production performance. The proposal of this work is to develop an integrated monitored and controlled system using LTCC (Low Temperature Co-Fired Ceramic) microreactors to generate polymeric nano/microparticles for encapsulation of hydrocortisone drug with PCL and Pluronic polymers. The microfluidic integ...
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2014 IEEE 9th IberoAmerican Congress on Sensors, 2014
Encapsulated nano/micro particles are highly used for biological, chemical, pharmaceutical and medical applications. The polymeric particles show potential capacity to release drugs and compatibility in biological environments. The emulsion/diffusion process is applied to produce these particles, and technologies based on microfluidic provide miniaturization of such process allowing particles with physical and chemical controlled characteristics. Nevertheless, the integrated system of technological devices like sensors, microactuators and controllers is crucial to improve the performance and efficiency of particles production with automatic cycles. The proposal of this work is to develop the integrated system to produce nano/microparticles for drug encapsulation, using microfluidics devices with control and automatic actions in continuous scale. The system is developed through devices integration, system characterization and control loops, using sensors, pumps, microfluidics devices, communication drivers, data acquisition, and control programs. The result of this work is the integrated system to produce particles of size 499-1500 nm with polydispersity index of 0.3 to 0.5 with potential to be used as drug delivery systems. The experimental results were validated by size measurement and polydispersity distribution with optical microscopy, scanning electron microscopy and dynamic light scattering.
Numerical and Experimental Analysis of Microfluidic Devices Manufactured in LTCC
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The mixture of fluids and reagents constitutes basic stage in many processes in industry and applied science, with applications in Medicine, Pharmacy and Analytical Chemistry. Microfluidic systems and devices display advantages as portability, small volumes of samples and continuous production. Microfluidic mixers with channel size from 1 mm to 1 μm, and flow speed typically of 1 m/s are being used for several applications. Reynolds number is smaller than 1000, characterizing laminar flow regime. Thus, in micro scale the mixture of fluids is dominated by diffusion mechanism, which is a slow and inefficient process. It is possible to speed up this process, by means of active and passive microfluidic devices. In this work an active and passive microfluidic mixers are considered. Devices are implemented in LTCC (Low Temperature Co-fired Ceramics) technology, driven by ultrasound where the mixing is done by mass transport. Passive devices are implemented using micro-channels with sharp ...
Structuration of microfluidic devices based on Low Temperature Co-fired Ceramic (LTCC) Technology
2005
Smart packaging concept has been the driving force for the search of advanced technologies to produce multifunctional micro-scale devices for long years. In this sense, LTCC technology has been recently addressed as the suitable choice for a wide range of applications. In addition to its attractive characteristics for high-frequency applications those have been profited for a long time, it receives a growing attention for sensor applications in the recent years as well. This is due to the easy maschinability of the LTCC tapes, which permits realization of complex structures such as membranes, channels, making it a suitable environment for micro-fluidic devices. These devices require utilization of supporting layers in order to prevent defects, often observed in forms of sagging, warpage or curling. The methods for elimination of these defects vary from passive precautions taken during lamination and firing to more elaborate methods such as use of sacrificial layers. The basic idea in the latter method is the preparation of a support, which can then be removed, leaving behind the desired structure. Among a number of alternatives, this paper focuses on and proposes the carbon-black sacrificial paste as an effective and simple method to fabricate membranes. Additionally determination of the open porosity elimination temperature in LTCC and effect of processing parameters on the fabricated structures, will be discussed. The methods of analysis will be TGA (thermo gravimetric analysis), dilatometer and SEM (scanning electron microscopy) analysis.