E-Beam Cross-Linking of Complex Hydrogels Formulation: The Influence of Poly(Ethylene Oxide) Concentration on the Hydrogel Properties (original) (raw)
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Macromolecular Research, 2018
Collagen (C)-poly(N-vinyl-2-pyrrolidone) (PVP) double-network superabsorbent hydrogels were synthesized by e-beam (electron beam) radiation processing, both with the addition of water-soluble cross-linking agents (CA), as well as without CA. The aim of the study was to develop a hydrogel for future application as wound dressings via e-beam radiation cross-linking of two biocompatible polymers. The formation of C-PVP hydrogels was confirmed by Fourier transform infrared (FTIR) spectroscopy and their performance was determined from morphological and rheological experiments, such as sol-gel analysis, swelling capacity, storage (G') and viscous (G'') moduli, cross-linking density, and pore size. Sol-gel analysis was performed in order to determine the gel properties as function of absorbed dose and it was found that the degradation density (p 0)/cross-linking density (q 0) ratio indicates a negligible contribution of chain scission processes. The rheological data confirmed that the elastic properties were predominant: G' moduli were larger than G'' moduli, as is specific to elastic solids and indicate the formation of a permanent hydrogel network were cross-links are present. Moreover, the swelling studies indicated that the hydrogels have good stability both in deionized water and phosphate-buffered saline (PBS) solution at 37 o C, and superabsorbent properties. The hydrogels network parameters obtained with lower content of CA, could be controlled by changing the absorbed dose.
Journal of Functional Biomaterials
Herein, three different recipes of multi-component hydrogels were synthesized by e-beam irradiation. These hydrogels were obtained from aqueous polymer mixtures in which different proportions of bovine collagen gel, sodium carboxymethylcellulose (CMC), poly(vinylpyrrolidone), chitosan, and poly(ethylene oxide) were used. The cross-linking reaction was carried out exclusively by e-beam cross-linking at 25 kGy, a dose of irradiation sufficient both to complete the cross-linking reaction and effective for hydrogel sterilization. The hydrogels developed in this study were tested in terms of physical and chemical stability, mechanical, structural, morphological, and biological properties. They are transparent, maintain their structure, are non-adhesive when handling, and most importantly, especially from the application point of view, have an elastic structure. Likewise, these hydrogels possessed different swelling degrees and expressed rheological behavior characteristic of soft solids ...
Correlations on the Structure and Properties of Collagen Hydrogels Produced by E-Beam Crosslinking
Materials
In this study, a collagen hydrogel using collagen exclusively produced in Romania, was obtained by electron beam (e-beam) crosslinking. The purpose of our study is to obtain new experimental data on the crosslinking of collagen and to predict as faithfully as possible, its behavior at high irradiation doses and energies. To pursue this, the correlations between macromolecular structure and properties of collagen hydrogels were determined by rheological analysis, Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Differential Scanning Calorimetry (DSC), respectively. The gel fraction, swelling degree, and network parameters of the collagen hydrogels were also investigated at different irradiation doses. Through experimental exploration, we concluded that irradiation with e-beam up to 25 kGy induces crosslinking processes in collagen structure without producing advanced degradation processes. E-beam technology is a great method to develop new mater...
We report on the successful preparation of wet dressings hydrogels based on Chitosan-Poly(N-Vinyl-Pyrrolidone)-Poly(ethylene glycol)-Poly(acrylic acid) and Poly(ethylene oxide) by e-beam cross-linking in weakly acidic media, to be used for rapid healing and pain release of infected skin wounds. The structure and compositions of hydrogels investigated according to sol-gel and swelling studies, network parameters, as well as FTIR and XPS analyses showed the efficient interaction of the hydrogel components upon irradiation, maintaining the bonding environment while the cross-linking degree increasing with the irradiation dose and the formation of a structure with the mesh size in the range 11-67 nm. Hydrogels with gel fraction above 85% and the best-swelling properties in different pH solutions were obtained for hydrogels produced with 15 kGy. The hydrogels are stable in the simulated physiological condition of an infected wound and show appropriate moisture retention capability and th...
Network structure studies on γ–irradiated collagen–PVP superabsorbent hydrogels
Radiation Physics and Chemistry, 2017
Collagen-polyvinylpyrrolidone (PVP) superabsorbent hydrogels were synthesized by γirradiation in the absence of oxygen, using high molecular weight PVP and acidic collagen Type I. Sol-gel analysis and swelling experiments were performed in order to determine the gel fraction, network parameters, the yield of cross-linking, respectively scission, as well as to establish the diffusion characteristics of water. Rheological experiments and characterization of the chemical structure before and after irradiation were conducted in order to evaluate the gel character and its stability upon irradiation. The relationship between these parameters and radiation dose was also established. Gel fraction reached up to 90 %, and the p 0 /q 0 ratio (degradation vs. cross-linking ratio) shows a negligible degradation process. The collagen-PVP hydrogels present swelling in the range 1000-2000 %, the diffusion exponent (n) was found to be between 0.59-0.68. The network parameters as the molecular weights between two successive cross links (), the cross-linking density () and the mesh size () are ranged between 3.39 8.08 , 1.24 2.95 , respectively 75-134 nm.
Synthesis and Swelling Characterization of Cross-Linked PVP/Pva Hydrogels
IRANIAN POLYMER …, 2005
Cross-linked poly(vinyl alcohol)/poly(vinyl pyrrolidone) (PVP/PVA) hydrogels were prepared in aqueous media using K 2 S 2 O8. The gel fraction, degree of swelling in water, and mechanical properties, such as TGA, DSC, and tensile strength were measured. It was found that the ...
2009
Hydrogels are three dimensional hydrophilic crosslinked polymeric networks that have capacity to swell by absorbing water or biological fluids without dissolve. Hydrogels have been widely used in different application fields from agriculture, industry and in biomedicine. The properties of a hydrogel are extremely important in selecting which materials are suitable for a specific application. So mixtures can offer hydrogels with different properties to different applications. The PVP hydrogels were prepared by gama radiation of an aqueous polymer solution and crosslinked by gamma ray, an effective and simple method for hydrogel formation that offers some advantages over the other techniques. In this work, a mixture experimental design was used to study the relationship between polymer cross-linking and swelling properties of PVP hydrogels with PEG as plasticizer and agar as gellifier. The gel fraction was measured for every mixture specified for the experiment D-optimal designs.
International Journal of Polymeric Materials and Polymeric Biomaterials, 2016
Hydrogels of poly(n-vinyl-2-pyrrolidone) (PVP) were produced by UV irradiation of aqueous solutions of the polymer in presence of hydrogen peroxide, used as crosslinker. The mechanical and the nano-structural properties of the gels were characterized by a combination of experimental techniques including rheology, low field nuclear magnetic resonance spectroscopy (LFNMR) and small angle X-ray scattering (SAXS). Different irradiation doses as well as polymer and crosslinker concentrations were tested in the characterization. The study elucidates the relationship between different methods to estimate the mesh size of the gel polymeric network. Moreover, a novel correlation model was developed based on Chui and Scherer theories for the interpretation of LFNMR dataset of polymer solutions and networks.