The gestational effect of antenatal corticosteroids on respiratory distress syndrome in very low birth weight infants: A population-based study (original) (raw)

Comparing neonatal respiratory morbidity in neonates delivered after 34 weeks of gestation with and without antenatal corticosteroid

Pakistan journal of medical sciences

To investigate the effect of antenatal corticosteroid prophylaxis on neonatal respiratory morbidity between 34 and 37 weeks of gestation. This retrospective study evaluated the neonatal respiratory complications of 683 low risk singleton pregnancies delivered at 34-37 weeks of gestation in a tertiary care center between Jan 2012 and Sept 2015. Group-I (n=294) comprised data of woman who did not receive betamethasone and Group-II(n=396) comprised those who received betamethasone after 34 weeks of gestation for cases at risk of preterm birth. Primary outcome was neonatal respiratory morbidity (NRM). NRM was defined as any respiratory disease that required medical support including supplemental oxygen, nasal continuous positive airway pressure, endotracheal intubation, or exogenous surfactant, with more than 25% oxygen for > 10 minute to maintain neonate oxygen saturation >90% Demographic characteristics, mode of delivery, fetal birth weight and neonatal respiratory complications...

Respiratory Morbidities and Neurodevelopmental Outcome in Preterm Infants of Mother Exposed to Antenatal Corticosteroids

International Journal of Current Research and Review

Introduction: Each year, about 15 million babies are born preterm, and 1 million babies die due to complications of preterm birth. Antenatal corticosteroid is one of the most effective evidence-based interventions that can reduce mortality and morbidity in preterm newborns. Objective: The purpose of this study was to evaluate the effect of antenatal corticosteroids on respiratory morbidities and neurodevelopmental outcomes among preterm neonates. Methodology: This prospective cohort study included admitted premature infant’s ≤ 34 weeks. Infant’s baseline demographics and maternal history of complete ACS exposure or no exposure were evaluated. Development of respiratory morbidities with support was compared between two groups during the neonatal period. After discharge from the NICU, neonates were followed up to assess neurodevelopment at 3rd and 6th months of age using Bayley Scales of Infant Development (BSID-III). Analysis was done to see the relationship with ACS exposure. Result...