FMolecular Identification of the Most Prevalent Mutations of the Glucose-6-Posphate Dehydrogenase (G6PD) Gene in Deficient Egyptian Patients (original) (raw)

2016

Abstract

FMolecular Identification of the Most Prevalent Mutations of the Glucose-6-Posphate Dehydrogenase (G6PD) Gene in Deficient Egyptian Patients Abeer Ramadan, Magda Abdel Aziz Zeidan, Naglaa Kholoussi, Howyda M Kamal Shaaban, Deena Abd El Latef Elshabrawy and Wahiba A Zarouk Division of Human Genetics & Genome Researches, Department of Molecular Genetics and Enzymology, National Research Centre, 33 Bohouth St. Dokki, Giza, Egypt Department of Clinical & Chemical Pathology, Faculty of Medicine Benha University, Egypt Abstract Introduction Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is a common human enzyme deficiency. Molecular abnormalities data from Egypt are scarce, and have not been extensively investigated. To fill this gap, we investigated the frequency of the presence of certain known G6PD mutations among Egyptian patients with G6PD-deficiency. Methods DNA was extracted from 50 G6PD-deficient unrelated male subjects. We have analyzed the G6PD gene mutations in those with ...

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