MAGE-A4 Interacts with the Liver Oncoprotein Gankyrin and Suppresses Its Tumorigenic Activity (original) (raw)
2003, Journal of Biological Chemistry
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To elucidate the possible involvement of gankyrin in ESCC progression and the effect of its down-regulation in ESCC, we investigated the expression of gankyrin in ESCC tissues comparing it with the corresponding normal esophageal epithelia and tested a short-hairpin RNA (shRNA) expression vector for gankyrin in ESCC cell lines. Gankyrin protein expression in 11 ESCC cell lines (KYSE series) was examined by RT-PCR and western blot. The expression of gankyrin mRNA in 30 ESCC tissues was compared with the corresponding normal epithelia by Real-time PCR. Expression of gankyrin protein was immunohistochemically analyzed in the ESCC of 103 patients. A gankyrin-shRNA vector was stably transfected into KYSE 170 cells to assess the role of gankyrin in cell motility, invasion and proliferation in vitro and tumor formation in vivo. Gankyrin expression increased in all 11 ESCC cell lines. Real-time PCR revealed that gankyrin expression was higher in the cancerous tissue for all 30 patients. In ...
Japanese Journal of Cardiovascular Surgery, 2010
IgG4 関連疾患はさまざまな臓器に起こりうるが，多くは腺管臓器においてであり，心血管領域での報告は 少ない．今回われわれは IgG4 関連疾患による冠動脈周囲腫瘍の 1 例を経験したので報告する．症例は 69 歳 男性．胸部 CT 上，2 年前から増大し続ける，冠動脈周囲の腫瘍性病変にたいし，確定診断目的で開胸生検 術を行った．病理組織診断では線維性結合組織内に形質細胞とリンパ球の密な増生を認め，好酸球も認めら れた．全体的に線維化が目立ち，一部で肥厚した膠原線維をともなっていた．免疫染色では形質細胞の多く は IgG4 陽性であり，生検後測定した血漿 IgG4 濃度は 1,080 mg/dl と高値を示した．以上から IgG4 関連疾 患の冠動脈周囲腫瘍と診断した．心血管領域の IgG4 関連疾患は非常に稀であり，本症例は IgG4 関連疾患 による冠動脈周囲炎が腫瘍性病変を呈したものと思われた．日心外会誌 39 巻 4 号：230-233(2010) キーワード：IgG4 関連疾患，心臓腫瘍，冠動脈周囲腫瘍
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