Influence of the nonlinear properties of the venous vascular wall on the deformation of vasa-vasorum (original) (raw)

Abstract

Known since a long time but relatively neglected, the venous vasa vasorum forms a tiny network to irrigate and drain the wall. Actually it is re-realized that, just like any tissues, the vein is a living tissue and the vasa vasorum plays a key role in the maintenance of its homeostasis. Under the effects of intraluminal pressure, the Young’s modulus (E) of the vein following an empirical relationship (LogE) 2 =-(αLog(p)+β), can vary in a very large range (a factor of 100) even in physiological conditions. We simulated the deformation of venous vasa vasorum by finite element method. Thus it can be suggested that, at first, a permanent venous hypertension provoques a local modification of the wall’s mechanical properties (decrease of E) to favorise a large deformation which will lead to a decrease of the irrigation, and secondly, with the decreased irrigation, the wall will loose its elasticity, become rigidified and keep its large deformation. A vicious cycle could be thus created.

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