An Effective Viscosupplementation Strategy for Treating Knee Joint: Preliminary Outcome from the In Vitro Study (original) (raw)

Journal of Bio- and Tribo-Corrosion, 2021

Abstract

To treat the knee joint disorder problem with less cost, viscosupplementation was introduced. However, the presence of poor adsorption properties in viscosupplementation might affect the pain relief percentage. Also, the key drawback of viscosupplementation is its inconsistency and fluctuating result in healing knee joint problem that tends to action disability. To address these issues, a novel Albumin blended Hyaluronic Acid (AbHA)-based viscosupplementation experimental work was prepared for treating knee joint problems. Here, the combination of Albumin and Hydraulic Acid is prepared and mixed thoroughly in an ultrasonic mixer. Here, the maximum possible content of albumin is equipped in the first sample, average content is equipped in the second sample, the minimum possible amount of albumin is prepared as the third sample, and the substance HA is utilized as general synovial fluid; the obtained proportions of HA and albumin ratios are 6:2.100, 6:0.480, and 6:0.075, respectively. Subsequently, a bovine plug is a stainless steel that is applied in the knee joint, and the pin-on-the-disk apparatus is utilized to test the wear rate and High-Frequency Reciprocating Test Rig. Finally, the rheological properties of the prepared sample are tested in the Anton par rheometer. Hereafter, tribological characteristics are measured and have attained the diminished wear as 13.51% and a low coefficient score of 0.02 for the proposed model. Also, the standard variation gained by the developed model is 4.3, which is less compared to other methods such as Anteromedial injection of HA, and in situ HA viscosupplement.

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