The growth hormone secretagogue receptor (original) (raw)

1999, Growth Hormone & IGF Research

In situ hybridization and ribonuclease protection assays, together with reverse transcription polymerase chain reaction (RT-PCR), have been used to localize expression of the GH secretagogue receptor. 5-z In the rat brain, the strongest expression of the GH secretagogue receptor mRNA was detected in the hypothalarnic nuclei, including the arcuate nucleus, ventromedial nucleus, lateral mamillary nucleus, anteroventral pre-optic nucleus, anterior hypothalamic area, suprachiasmatic nucleus, lateroanterior hypothalamic nucleus, paraventricular nucleus, periventricular nucleus, dorsomedial nucleus and the tuberomamillary nucleus. Recently, it has been shown that the GH secretagogue receptor is co-localized with approximately 25% of the GH-releasing hormone (GHRH)