Severe Asthma in adolescents and adults: a National, multicenter registry in real life (original) (raw)
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Developments in the field of allergy in 2009 through the eyes of Clinical and Experimental Allergy
Clinical & Experimental Allergy, 2010
In 2009 the journal published in the region of 200 papers including reviews, editorials, opinion pieces and original papers that ran the full gamut of allergic disease. It is instructive to take stock of this output to determine patterns of interest and where the cutting edge lies. We have surveyed the field of allergic disease as seen through the pages of Clinical and Experimental Allergy (CEA) highlighting trends, emphasizing notable observations and placing discoveries in the context of other key papers published during the year. The review is divided into similar sections as the journal. In the field of Asthma and Rhinitis CEA has contributed significantly to the debate about asthma phenotypes and expressed opinions about the cause of intrinsic asthma. It has also added its halfpennyworth to the hunt for meaningful biomarkers. In Mechanisms the considerable interest in T cell subsets including Th17 and T regulatory cells continues apace and the discipline of Epidemiology continues to invoke a steady stream of papers on risk factors for asthma with investigators still trying to explain the post-second world war epidemic of allergic disease. Experimental Models continue to make important contributions to our understanding of pathogenesis of allergic disease and in the Clinical Allergy section various angles on immunotherapy are explored. New allergens continue to be described in the allergens section to make those allergen chips even more complicated. A rich and vibrant year helpfully summarized by some of our associate editors. Asthma and rhinitis Definition and phenotypes of asthma Although the latest GINA definition of asthma is widely accepted, it remains confused because it fails to identify a primary characteristic which separates it from other diseases [1].
Allergy, 2004
Usually medical societies have one official organ which often is a peer-reviewed journal. For example, the Journal of Allergy and Clinical Immunology is the official organ of the American Academy of Allergology, Asthma and Immunology (AAAAI), the Annals of Allergy, Asthma and Immunology represents the American College of Allergy, Asthma and Immunology (ACAAI) and Clinical Experimental Allergy represents the British Society for Allergy and Clinical Immunology (BSCAI). However, the World Allergy Organization has two officials organs: Allergy Clinical Immunology International (ACII) and International Archives of Allergy and Immunology (IAAI). Uniquely, the European Academy of Allergology and Clinical Immunology (EAACI) has two mutually complementary official organs: Allergy and Pediatric Allergy and Immunology (PAI). The reasons for explaining why EAACI is involved in these two publications are historical but they are also supported by the current and future interests of EAACI. Acata Allergologica was the official EAACI organ since the founding organization of the Academy and used to publish papers in other languages than English. Subsequently, the journal was renamed ÔÔAllergyÕÕ and only published papers in English. The journal has been published for the past 60 years. Gunnar Bendixen was its editor for many years until 1992 when Prof SGO Johansson became the editor-in-chief. Gunnar made the journal what it is now, by improving its quality, introducing regular reviews, series and editorials and the journal peaked an impact factor of 3.6 in 2002 (1). The Junior Members and Junior Affiliate Members represent a group of more 1000 clinicians and scientists under the age of 35. During previous years, EAACI has developed specific activities and promotions to support the and increase the influence of the younger members (2). Thus, a new series, the Junior Member Forum, was therefore introduced in Allergy in September 2002 in order to publish the work of young scientists together with their mentor (3). Papers published in this series cover science from bench to bedside. In January 2003, Jean Bousquet had the pleasure and difficult task to continue Gunnar's work (4). With a renewed board of Associate Editors reflecting the EAACI sections (Asthma: Marc Humbert, Clinical Immunology: Hans-Uwe Simon, Dermatology: Thomas Bieber, ENT: Wystke Fokkens and Pediatrics: Bodo Niggemann) and the importance of Central European countries (Marek Kowalski), we have introduced new topics such as News and Commentaries or the European Union Forum (5). The contents of Allergy should reflect EAACI sections and interest groups. It is clear that during the past three years Allergy has tried to publish reviews, editorials, position papers and commentaries which are encapsulating all fields of Allergy and Clinical Immunology (Table I). Some key articles such as the revised nomenclature for allergic diseases were also published in Allergy (6). Moreover, important educational papers such as the Core Curiculum for the training in Allergology and Clinical Immunology are in Allergy (7, 8) Allergic diseases start early in life and the prevalence of allergic diseases is higher in children and adolescents by comparison with that in adults and rates are still increasing. Furthermore, asthma and related allergic and respiratory diseases constitute the commonest causes of morbidity in childhood with around 30% of primary care consutlations and 20% of hospital admissions. Immunologically driven diseases are common and of
Asthma: From Disease to Treatment - An Overview
2020
Asthma is the popular respiratory problems in the modern industrialized countries, affecting over 300 million people. It affects all age group from infant to senior citizens, and mortality rate from asthma appear to be increased during the past few years in the United States as well as in the other industrialized area. Asthma tends to occur in the family, associated with other allergic diseases, and may be induced by a variety of environmental allergens, most commonly inhaled allergens such as pollen and dust having numerous types. Bronchial scorns the allergens result in former bronchospastic response for a brief duration and some of the patients there is a late response with onset after 3 to 4 hours, lasting hours to days. This late reaction is related to the bronchial extreme touchiness response. This is a self-evident by vague test testing in the research facility. During the time of bronchial hyperresponsiveness understanding is inclined to create assaults following introductio...
It is well recognized that atopic sensitization is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term 'Severe Asthma' encompasses a highly heterogeneous group of patients who require treatment on steps 4–5 of GINA guidelines to prevent their asthma from becoming 'uncontrolled', or whose disease remains 'uncontrolled' despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations. In addition, allergic asthma in childhood is often associated with severe asthma in adulthood. A strong association exists between asthma exacerbations and respiratory viral infections, and interaction between viruses and allergy further increases the risk of asthma exacerbations. Furthermore, fungal allergy has been shown to play an important role in severe asthma. Other contributing factors include smoking, pollution and work-related exposures. The 'Allergy and Asthma Severity' EAACI Task Force examined the current evidence and produced this position document on the role of allergy in severe asthma.
Severe Asthma and Allergy: A Pediatric Perspective
Frontiers in Pediatrics
Severe asthma in children is associated with significant morbidity and lung function decline. It represents a highly heterogeneous disorder with multiple clinical phenotypes. As its management is demanding, the social and economic burden are impressive. Several co-morbidities may contribute to worsen asthma control and complicate diagnostic and therapeutic management of severe asthmatic patients. Allergen sensitization and/or allergy symptoms may predict asthma onset and severity. A better framing of "allergen sensitization" and understanding of mechanisms underlying progression of atopic march could improve the management and the long-term outcomes of pediatric severe asthma. This review focuses on the current knowledge about interactions between severe asthma and allergies.
ARIA Update 2008: die allergische Rhinitis und ihr Einfluss auf das Asthma
Allergologie, 2009
Immunology. J. Correia de Sousa has board memberships with Boehringer Ingelheim and Novartis, has received payment for lectures from Boehringer Ingelheim, and has received payment for development of educational presentations from Boehringer Ingelheim. A. A. Cruz has board memberships with Novartis, Boehringer Ingelheim, AstraZeneca, MEDA Pharma, and GlaxoSmithKline; has consultant arrangements with Boehringer Ingelheim; has provided expert testimony for Boehringer Ingelheim; has received grants from GlaxoSmithKline; and has received payment for lectures from Eurofarma, Chiesi, MEDA Pharma, and Hypermarcas-Ache. C. A. Cuello-Garcia has consultant arrangements with and has received payment for manuscript preparation and travel support from the World Allergy Organization. P. Demoly has received consulting fees from ALK-Abell o, Stallergenes Greer, Thermo Fisher Scientific, MEDA, Chiesi, and Ysslab and has received grants from AstraZeneca. M.