Infant gut microbiota and food sensitization: associations in the first year of life (original) (raw)

Abstract

The gut microbiota is established during infancy and plays a fundamental role in shaping host immunity. Colonization patterns may influence the development of atopic disease, but existing evidence is limited and conflicting. To explore associations of infant gut microbiota and food sensitization. Food sensitization at 1 year was determined by skin prick testing in 166 infants from the population-based Canadian Healthy Infant Longitudinal Development (CHILD) study. Fecal samples were collected at 3 and 12 months, and microbiota was characterized by Illumina 16S rRNA sequencing. Twelve infants (7.2%) were sensitized to ≥1 common food allergen at 1 year. Enterobacteriaceae were over-represented and Bacteroidaceae were under-represented in the gut microbiota of food-sensitized infants at 3 months and 1 year, whereas lower microbiota richness was evident only at 3 months. Each quartile increase in richness at 3 months was associated with a 55% reduction in risk for food sensitization by ...

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