Polyunsaturated Fatty Acid Enrichment Increases Ultraviolet A-Induced Lipid Peroxidation in NCTC 2544 Human Keratinocytes (original) (raw)

1995, Journal of Investigative Dermatology

Abstract

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The study investigates the impact of supplemented polyunsaturated fatty acids on ultraviolet A (UVA)-induced lipid peroxidation in NCTC 2544 human keratinocytes. It identifies a significant increase in thiobarbituric acid reactive substances (TBARS) following exposure to UVA, with arachidonic acid exhibiting the greatest effect. Notably, the extent of lipid peroxidation was closely tied to the fatty acid's degree of unsaturation and was influenced by the presence of antioxidants like vitamin E.

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