Calcium Decay Ability of Extracts Chromolaena odorata L. Leaves (Asteraceae) on Kidney Stones (original) (raw)
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Phytochemical Screening of Some Important Medicinal Plants Used for Kidney Stone
International journal of pharmaceutical sciences review and research, 2023
Phytochemicals are bioactive compounds obtained from the Solanum xanthocarpum, Bryophyllum Pinnatum, Tridex procumbence and Phyllanthus emblica plant are widely applied in the traditional herbal medicine. These four plants were collected from local nursery located in Katol taluka of Maharashtra, India. These plants are being used for the treatment of kidney stones disease in and around the region. The parts of plants are shade dried for seven to fifteen days. A fine powder has been prepared of dried leaves, stem and root. Phytochemical analysis is carried in aqueous and methanol extracts. It shows the presence of Alkaloids, Tannins, Saponins, Protein, Steroids, Quinones etc. in these extracts. Thin Layer Chromatography study constituted different colored phytochemical compounds with different Rf values. These four plants contain many active phytochemicals. It can be further investigated for the isolation and identification of active biochemical compound.
Mediterranean Journal of Chemistry
Objective: This study was carried out to evaluate the efficiency of plant extracts used in traditional medicine on the dissolution of oxalo-calcic and cystine stones. Also, the efficiency of phenolic fractions (Tannins and Flavonoids) for the plants that gave us the best stone dissolution rate. Subjects and methods: Kidney stone of oxalo-calcic and cystine stones were incubated in vitro for 8 weeks in the presence of five plants extracts (hydro-ethanolic and aqueous extracts). NaCl solution (0,9 %) used as negative control and sodium citrate solution at 3 mM/L as a positive control. The studied plants were Herniaria hirsuta L. aerial parts, Opuntia ficus-indica L. flowers, Zea mays L. stigmata, Ammi visnaga L. seeds and Ziziphus lotus L. fruits. After 2, 4, 6 and 8 weeks the stones were weighed after 18 h drying at 40°C and the dissolution rate of the stones and the pH of the solution were measured.Results: After eight weeks, all the plant extracts and phenolic fractions had reveale...
Today a wide-ranging number of population in the world is enduring from disease like a kidney stone, the most usual cause of the kidney stone is a poor lifestyle, less water intake, and inappropriate dietary habits. This Problem is, very obsolete and these stones are found in various parts of the body, such as the urinary bladder, kidney, ureter, and urinary tract. Herb plants have been used since old times due to their additional safety, and efficacy as well as subsidiary side effects in comparison with current synthetic drugs. Consequently, in this article, we have provided an outline of the several herbal plants which inhibit the process of stone formation and show stone dissolving activity due to their diuretic, anti-inflammatory, and anti-oxidant-like properties and various phytoconstituents like sterols, alkaloids, flavonoids, and saponins, etc.
In vitro litholytic activity of some medicinal plants on urinary stones
African Journal of Urology
Objective: This study was designed to evaluate the effect of plant extracts used in traditional medicine on the dissolution of three types of kidney stones. Subjects and methods: Kidney calculi of cystine; uric acid and pure carbapatite were incubated in vitro during 6 weeks in the presence of three of plant extracts and of 0.9% NaCl solution used as control. An extract of each plant was prepared by infusion of three grams of powdered plants during 30 min in 100 mL of a boiled NaCl 0.9% aqueous solution. Each extract was then filtered and thereafter set in a flask containing a stones. At the end of each week the stone was removed from the experimental medium and weighted after a 18 h drying at 40 • C. Results: After 6 weeks of experiment and with in vitro study, we are observed that the aqueous extract of the seeds of Trigonella foenum-graecum has a better effect on dissolution of cystine and carbapatite stones (p < 0.05), with mass loss of 94 mg and 73 mg respectively at the end of experiment. While with NaCl solution, the mass was small. Conclusion: Our experiment failed to demonstrate a significant effect of the tested plant extracts to dissolve three types stones in vitro. However, we observed that only the extract of the seeds of T. foenum-graecum has a better effect on dissolution of cystine and carbapatite stones probably resulting from formation of complexes between stones and polyphenols or flavonoids present in the extracts.
Free Radicals and Antioxidants, 2021
Introduction: Free radicals are capable of inducing oxidative damage, which causes various human diseases. However, antioxidants reduce the risk of diseases related to reactive oxygen species. Medicinal plants such as Achyranthes aspera leaves, Satureja punctata aerial parts, Aloe pulcherrima gel, Gomphocarpus fruticosus leaves and Commiphora myrrha resins were claimed to treat various ailments including urolithiasis in Ethiopia. Objectives: This study was intended to determine phytochemicals and antioxidant activities of the aforementioned plants. Materials and Methods: Plants were collected and the aqueous crude extracts were prepared. Phytochemicals were screened qualitatively and DPPH(2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay was measured at 517nm using UV-Vis spectrophotometry. Data were analyzed statistically using one-way ANOVA, Dunnett’s comparison test of the Graph Pad Prism version 6. Results: The plant extracts exhibited various phytochemicals such as phenol...
https://www.ijhsr.org/IJHSR\_Vol.12\_Issue.9\_Sep2022/IJHSR-Abstract21.html, 2022
Many novel compounds had obtained from the plants having medicinal property. Among the medicinal plants, those having antiurolithiatic properties are important and are very effective in controlling and curing of stone formation in the urinary tract. The inhibitory effect of aqueous methanolic extract of traditionally used medicinal plants were studied on the formation of calcium oxalate (CaOX) stone in aqueous as well as in urinary medium. The inhibitory effects were presented as the percentage of inhibition or the degree of inhibition as compared to blank urine. The inhibition in stone formation is due to its capacity of increasing the solubility product of its constituents and is determined through chemoinhibition experiment. The antiurolithiatic properties of different medicinal plants were studied and presented in decreasing order in the present work. The finding give support the effectiveness of many medicinal plants against the urolithiatic cases specially in CaOX formation as used in the folklore medicine.
Integrative Medicine Research
Background: The use of plants and plant products for medicinal purposes is an age-long practice in traditional communities and is becoming prominent globally. This study was performed to evaluate the effect of ethanolic extract of Chromolaena odorata on the kidney and intestine of albino rats. Methods: Twenty growing albino rats with an average weight of 54 g were used in this study. They were grouped into four groups. Groups 1, 2, and 3, known as the test groups, were given 50 mg/kg, 100 mg/kg, and 250 mg/kg ethanolic extract of C. odorata, respectively, while the control group was given distilled water orally. The experiment was performed for 6 weeks. The animals were killed using chloroform suffocation. The kidneys and the intestine were harvested and fixed in 10% neutral buffered formalin for histological analysis. Blood samples were collected from the animals by heart puncture for estimation of creatinine and urea levels. Results: The creatinine, urea, aspartate aminotransferase, alanine transaminase, and alkaline phosphatase levels of blood sample from the test group were significantly different when compared with the control (p < 0.05). The histological sections of the kidneys in this study showed no signs of degeneration. Infiltration of inflammatory cells and epithelial erosion were observed in the histology sections of the intestine of all the test groups. Conclusion: The results from this study revealed that uncontrolled use of this plant extract has an adverse effect on the kidney function and on the histology of the intestine of the rats used in this study.
UROLITHIATIC ACTIVITY OF LAUNEA PROCUMBENS AGAINST CALCIUM OXALATE AND CALCIUM PHOSPHATE STONES
Launea procumbens commonly known as Pathari belonging to family asteraceae has been investigated for its anti-urolithiatic activity by constructing an in-vitro model. Various crude extracts of Launea procumbens were evaluated for their potential to dissolve experimentally prepared kidney stones of Calcium oxalate,Calcium phosphate and the results were compared with cystone as a standard polyherbal drug. The detailed phytochemical screening was done to identify active phytoconstituents and photo-micrography was carried out to understand dissolution of stones by extracts.Chloroform ,alcoholic and acetone fractions of plant leaves showed highest dissolution of Calcium oxalate stones as compare to others (63,49,40% resp.) while ethyl acetate, pet ether, acetone fractions of plant leaves were more effective in dissolving Calcium Phosphate (80,30,25% resp.) compared to reference standard-formulation Cystone.
Pharmacological Importance of Chromolaena odorata: a review
2021
Chromolaena odorata (Asteraceae) is commonly referred to as Siam Weed, a major medicinal plant found in tropical Asia, Australia, and West Africa. The medicinal use of Chromolaena odorata had been documented in the conventional system such as the Siddha, Unani, Ayurveda. The pharmacological properties of this plant are widely varying. A wide variety of attractive but limited compounds were extracted from this Chromolaena odorata and the pharmacological activities were screened out. This review the various properties of Chromolaena odorata and focus on its various medicinal properties. It is an attractive subject for further experimental and clinical investigations. This article will give an exhaustive summary and analysis of Chromolaena odorata pharmacological activities. The present article including the detailed exploration of pharmacological properties of C. odorata is an attempt to provide a direction for further research.
Screening of selected plants for their effectiveness in the treatment of kidney stone
Annals of Phytomedicine: An International Journal, 2020
Kidney ailments have increased several folds in the last two decades. Kidney stones are one of the most common urinary tract problems to be found. It has been associated with increased risk of renal failure if not treated in the early stages. Kidney stones are well known as renal calculus. They are mainly composed of minerals like calcium oxalate. An interaction with the local practitioners in Raigad district of Maharashtra, India revealed that several plant species are being used as lithotriptic agents. A simple technique has been designed to evaluate the lithotriptic activity of extracts of leaves of Bauhinia purpurea L., seeds of Celosia argentea L. and seeds of Macrotyloma uniflorum (Lam.) Verdc. Cystoliths and raphides which are aggregation of minerals are used as target minerals and their dissolution by the extracts of these plants are used as technique for evaluating the efficacy of these plants as lithotriptic agents.