a-Interferon Activates the Natural Killer System in Patients With Hairy Cell Leukemia (original) (raw)

1986

Abstract

To elucidate the mechanisms of a-interferon's (a-INF) therapeutic effect on clinical and laboratory findings in hairy cell leukemia. we sequentially monitored different immunologic parameters in three patients treated with recombinant a-INF. The most evident effect of this treat- ment on the immune system was the recovery of natural killer (NK) cell in vitro activity of peripheral blood lympho- H AIRY CELL LEUKEMIA (HCL) is a malignant B cell disorder usually characterized by isolated spleno- megaly and peripheral pancytopenia associated with the presence in the blood of mononuclear hairy cells that infil- trate the spleen and bone marrow."2 Although splenectomy has been the treatment of choice in this disease for a number of years, a large number of patients fail to respond to this approach.2 The use of different therapeutic strategies based on chemotherapeutic agents has been unsatisfactory.3 A highly effective treatment of these patients has been recently offered by a-i...

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