Evaluation of apolipoproteins A-I and B as markers of angiographically assessed coronary artery disease (original) (raw)
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The association between serum apolipoprotein A-I and apolipoprotein B, and the severity of
Introduction: The aim of this study was to investigate the relationship between serum apolipoprotein A-I (apoA-I) and apolipoprotein B (apoB) and the severity of coronary artery stenosis. Methods: This case-control study was carried out on 106 patients who underwent angiography and 100 healthy controls. ApoA-I and apoB as well as the serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride and low-density lipoprotein cholesterol (LDL-C) levels were measured. Very low-density lipoprotein cholesterol levels and the LDL-C/HDL-C ratio were calculated. Results: In an Iranian population with coronary artery disease (79 men and 27 women, aged 53 +/− 8.5 years), the increased levels of apoA-I and apoB were correlated with the number of involved vessels and the severity of coronary lesions. However, no significant correlation was found between the serum values of lipids as well as other lipoproteins and the number of vessels involved and the severity of coronary lesions. Conclusion: ApoA-I and apoB are indicated as risk factors for cardiovascular and, possibly, cerebrovascular diseases. From this study, it may be concluded that apoA-I and apoB serum concentration levels are independent risk factors for coronary atherosclerosis in the Iranian population. It also demonstrates a direct relationship between the severity of coronary atherosclerosis and the number of lesions in the involved vessels. It can be regarded as an index for the relationship of apoA-I and apoB to the early, still clinically asymptomatic, steps of the pathogenesis of coronary disease.
IP innovative publication pvt. ltd, 2019
Introduction: Cardiovascular disease is the most common cause of death worldwide among which coronary heart disease (CHD) is the main culprit. Conventionally the estimation of serum lipids like cholesterol, triglycerides, LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C) are used to assess the risk of CHD. However, the inaccuracies in the correlation between serum lipid profile and CHD, led to the development of better indicators. Among them the estimation of serum apolipoprotein is now increasingly used for risk assessment of CHD. In HDL-C main protein component is Apolipoprotein A-I. Apo A-I and HDL-C are protective; Apolipoprotein B (Apo B) and LDL-C are atherogenic. The current study is carried out to evaluate and compare the efficacy of Apo B and Apo A-I level with LDL-C and HDL-C level as risk factors of coronary heart disease. Materials and Methods: Total 45 clinically diagnosed patients of coronary heart disease with age group of 30-65 years and 45 age and sex matched healthy individuals were included in study. Their serum levels of Apo A-I, Apo B, total cholesterol, HDL-C, LDL-C triglycerides and VLDL-C were measured and compared between CHD patients and healthy controls. Results: No significant difference was found in total cholesterol (TC), HDL cholesterol and LDL cholesterol levels, only VLDL cholesterol was significantly higher in CHD patients compared to controls (p < 0.05). Apolipoprotein A-1 was lower and Apolipoprotein B was higher in CHD patients compared to controls and the differences were highly significant (p < 0.001). Conclusions: This study indicates ratio of Total Cholesterol to HDL-C and LDL-C to HDL-C can be helpful in assessing risk of CHD while raised Apo B to Apo A-I ratio is highly suggestive risk factor for CHD.
Journal of Biosciences and Medicines, 2015
Atherosclerosis is the most important contributor to increasing burden of coronary artery disease (CAD). Growing evidence suggests that the ratios of Apo B/Apo A-I and Lp(a) are better indexes for risk assessment of CAD. Elevated plasma levels of lipoprotein(a) in humans represent a major inherited risk factor for atherosclerosis. Thus, a study was performed to determine the association betwwen serum Apo B, Apo A-I, and lipoprotein(a) levels, and severity of CAD in patients with CAD confirmed on coronary angiography findings. An analytical case control study was carried out with 85 patients (58 males and 27 females) 40 -60 years of age confirmed as having CAD on coronary angiography and 85 age and sex matched healthy volunteers as controls. Serum samples were analyzed for Apo A-1 LDL, Apo B, Apo A-I, and lipoprotein(a) concentration and the severity of CAD was assessed using coronary angiography scoring method. Patients with CAD had significantly high serum LDL-C, Apo B and Lp(a) levels compared to control subjects. However, serum Apo A-I level did not show a significant difference between two groups. Subjects with a positive family history of CAD with increased serum Lp(a) ≥ 17.3 mg/dL have high risk for development of CAD. Present study suggests that serum Lp(a) cut-off value of 17.3 mg/dL may be an important predictor in ruling out major vessel disease and luminal narrowing by atheroma.
APOLIPOPROTEIN B / A1 RATIO AS RISK PREDICTOR OF ANGIOGRAPHICALLY PROVEN ATHEROSCLEROSIS
Background:-Apolipoproteins B and A-1 form major component of lipoproteins which are known to be involved in the pathogenesis of atherosclerosis. ApoB/Apo A-1 ratio reflects the balance between atherogenic and anti atherogenic particles thus reflecting the net atherogenic risk in such subjects. Objectives:-To estimate serum Apo B and Apo A1 level and assess the role of their ratio apoB/apoA-1 as atherosclerosis risk predictor ofangiographically proven athrerosclerosis. Material and Methods:-Study population consisted of angiographically documented 50 cases with coronary artery atherosclerosis and 50 controls without atherosclerosis of coronary artery. Serum lipid profile was measured on SYNCHRON CX-9 using standard kits. Serum apolipoprotein A and B were measured by immunoturbidemetric method on SYNCHRON CX-9using kits from SENTINEL. Results:-Apo B/ Apo A1 ratio was significantly higher in cases than controls with p=0.008. No significant difference was found in conventional lipid markers of cases and controls. Conclusion:-Apo B/ apo A1 ratio is a better atherosclerosis risk predictor than conventional lipid markers in angiographically proven atherosclerosis.
Clinical Chemistry and Laboratory Medicine (CCLM), 2006
Background: The ratio of low-to high-density lipoprotein-cholesterol (LDL-C/HDL-C) conventionally represents the balance of proatherogenic and antiatherogenic lipids. However, growing evidence supports the idea that the ratio of apolipoprotein (apo) B/ apoAI is a better index for risk assessment of coronary artery disease (CAD). The aim of this study was to evaluate the efficiency of advanced profile of serum (apo)lipoproteins for predicting stable CAD in secondary prevention. Methods: The study subjects, 138 men and 126 women aged 40-70 years, were classified as CAD cases or controls, according to the results of coronary angiography. The severity of CAD was scored on the basis of the number and extent of lesions in coronary arteries. Serum (apo)lipoproteins were measured by immunoturbidometric and electrophoresis methods. Results: Patients with CAD compared with controls had increased serum levels of triglycerides (2.6"2.0 vs. 2.0"1.2 mmol/L, pF0.005), apoB (1.36"0.31 vs. 1.19"0.24 g/L, pF0.0001), lipoprotein(a) wLp(a)x (0.69"0.60 vs. 0.43"0.31 g/L, pF0.0001) and apoB/ apoAI ratio (1.07"0.32 vs. 0.87"0.18, pF0.0001), and decreased serum levels of HDL-C (1.02"0.29 vs. 1.11"0.34 mmol/L, pF0.03), apoAI (1.32"0.22 vs. 1.37"0.19 g/L, pF0.04) and LDL-C/apoB ratio (0.91"0.32 vs. 1.02"0.25 mmol/g, pF0.01). Multiple logistic regression analysis after adjusting for major risk factors showed that the apoB/apoAI ratio, apoB and Lp(a) were among seven significant and independent determinants of CAD. The area under the receiver operating characteristic (ROC) curves (AUC) as a relative measure of test efficiency was highest and significant for the apoB/apoAI ratio (AUCs0.71, pF0.0001), apoB (0.67, pF0.0001), Lp(a) (0.63, pF0.001), the LDL-C/apoB ratio (0.62, pF0.006), triglycerides (0.62, pF0.004) and apoAI (0.58, pF0.05). ANOVA analysis showed significant association for the apoB/apoAI ratio, apoB, Lp(a) and triglycerides, and moderate association for total cholesterol and its subfractions, with the severity of CAD. Conclusions: The results indicate that the apoB/apoAI ratio, apoB and Lp(a) are independent risk factors for
Arquivos brasileiros de …, 1999
Objective-To evaluate whether apolipoproteins A-I (Apo A-I) and B (Apo B) have, higher ensitivity (SN), specificity (SP) and positive predictive value (PPV) than lipoproteins (LP), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and triglycerides (TGL) in assessing the risk of coronary heart disease (CHD). Methods-This is a transversal case-control study of 241 patients, who were divided into two groups: 1) 145 patients with CHD, and 2) 96 patients without coronary disease. A model of logistic regression to evaluate the relation between the LPs and CHD was developed in which variables with a p-alpha <0.1 were included.
The apolipoprotein b/apolipoprotein a-I ratio as a potential marker of plasma atherogenicity
Disease markers, 2015
Background. The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting the presence or absence of cardiovascular disease, less is known about apoB/apoA-I ratio as a marker of plasma atherogenicity. Methods. A total of 157 normolipidemic men aged 20-59 years were included in the study. The plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apoA-I, apoB, and apoE were determined after a 12 h fasting period. Results. The median of the apoB/apoA-I ratio in the studied normolipidemic subjects was 0.52, with values ranging from 0.19 to 2.60. The percentage of subjects with the apoB/apoA-I ratio exceeding 0.9 (the accepted risk value of cardiovascular disease) was 19.1%. The subjects with a...
Predictive value of apolipoproteins in a prospective survey of coronary artery disease in men
The American Journal of Cardiology, 1992
Some studies have suggested that measurements of apolipoproteins may be valuable in the clinical assessment of susceptibility to coronary artery disease, over and above the lipoprotein lipids. Only a few of these studies have been prospective in nature and further knowledge is therefore needed to clarify the issue. The independent prognostic value of apolipoproteins (apo-B, apo-Al and apo[a]) with regard to coronary artery disease was estimated from a prospective survey among 1,332 randomly setected Icelandic men, aged 45 to 72 years, participating in a health survey from 1979 to 1981. The group was followed for 8.6 years, and during that period 104 men had fatal or nonfatal myocardial infarction. The Cox's proportional hazards model was used to estimate the significance of independent variables. The resuits of multivariate analysis showed that ape(a) was a stgnificant independent risk factor (odds ratio 1.22 for 1 SD), but ape-Al was a stronger negative risk factor (odds ratio 0.70 for 1 SD). Apo-B was a highly signtficant risk factor in a univariate analysis, but not in a multivariate analysis when serum cholesterol was included. Previous population surveys in Iceland have confirmed the importance of cigarette smoking, cholesterol, triglycerides and bland pressure as risk factors for coronary artery disease. The present results illustrate additional importance of apo-Al and ape(a) concentrations in predicting coronary artery disease among Icelandic men, whereas apo-B did not contribute anything further to the prediction than serum total cholesterol.