Discovery of novel Bruton's tyrosine kinase (BTK) inhibitors bearing a pyrrolo[2,3-d]pyrimidine scaffold
Yang Ge
Bioorganic & medicinal chemistry, 2014
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Potent and Selective Bruton’s Tyrosine Kinase Inhibitors: Discovery of GDC-0834
Scott Mitchell
Bioorganic & Medicinal Chemistry Letters, 2015
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Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes
Thierry Fischmann
Bioorganic & Medicinal Chemistry Letters, 2020
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Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors
Zhenquan Hu
European journal of medicinal chemistry, 2017
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Development of a Scalable Synthesis for the Potent Kinase Inhibitor, BMS-986236; 1-(5-(4-(3-hydroxy-3-methylbutyl)-1H-1,2,3-triazol-1-yl)-4-(isopropylamino) pyridin-2-yl)-1H-pyrazolo[3,4-b] pyridine-5-carbonitrile
Anki Reddy
Organic Process Research & Development, 2019
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Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase
Kevin D Jerome, Jeff Hitchcock, Brian Hickory
Bioorganic & Medicinal Chemistry Letters, 2011
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Discovery of 3-[2-(Imidazo[1,2- b ]pyridazin-3-yl)ethynyl]-4-methyl- N -{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant
Xiaotian Zhu, Raji Sundaramoorthi
Journal of Medicinal Chemistry, 2010
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Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization
Michael Kubbutat
Bioorganic & Medicinal Chemistry, 2009
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Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors
Steven Kim
Bioorganic & Medicinal Chemistry Letters, 2009
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Design, synthesis, anticancer evaluation and molecular docking of new V600EBRAF inhibitors derived from pyridopyrazinone
Prof. Mandava venkata Basaveswara Rao
European Journal of Chemistry, 2016
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The pyrazolobenzothiazine core as a new chemotype of p38 alpha mitogen-activated protein kinase inhibitors
Maria Letizia Barreca
Chemical biology & drug design, 2015
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Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation
Juan Espinosa
Bioorganic & medicinal chemistry letters, 2004
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Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor
Zhenquan Hu
European journal of medicinal chemistry, 2017
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p38 MAP kinase inhibitors. Part 6: 2-Arylpyridazin-3-ones as templates for inhibitor design
Giovanna Scapin
Bioorganic & Medicinal Chemistry Letters, 2006
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Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors
Claire Delehouze
European journal of medicinal chemistry, 2016
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The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines
Juan Manuel Real Espinosa
Molecular Cancer Therapeutics, 2004
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Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors
Gerald Shipps
Bioorganic & Medicinal Chemistry Letters, 2011
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Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties
Adam Johnson
ACS medicinal chemistry letters, 2017
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Discovery of novel BTK inhibitors with carboxylic acids
Thierry Fischmann
Bioorganic & Medicinal Chemistry Letters, 2017
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Synthesis and biological evaluation of 3,6-diamino-1 H-pyrazolo[3,4- b]pyridine derivatives as protein kinase inhibitors
Abdelouahid Samadi
Bioorganic & Medicinal Chemistry Letters, 19 (16), 4566-4569, 2009 , 2009
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Discovery and Evaluation of 7-Alkyl-1,5-bis-aryl-pyrazolopyridinones as Highly Potent, Selective, and Orally Efficacious Inhibitors of p38α Mitogen-Activated Protein Kinase ⊥ ⊥ Atomic coordinates and structure factors for crystal structure of compound 3d with p38α can be accessed using PDB code 3LHJ
Helen McBride, Ryan Wurz
Journal of Medicinal Chemistry, 2010
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Ethyl 2-(benzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate analogues as a new scaffold for protein kinase casein kinase 2 inhibitor
Kyu-Yeon Jun
Bioorganic & medicinal chemistry, 2014
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Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains
Jose Miguel Lizcano
ACS chemical biology, 2018
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