CODEN (USA): PCHHAX Effect of nicotinic acetylcholine receptors polymorphism in Egyptian males with chronic obstructive pulmonary disease (original) (raw)
The major reinforcing component of tobacco smoke is Nicotine which acts through neuronal nicotinic acetylcholine receptors (nAChRs). It is a strong predisposing factor for the development of chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the associations between single nucleotide polymorphism (SNP) of nAChRs rs1051730 and demographic (including smoking index and cigarette consumption per day), physiologic and lab characteristics of Egyptian males with COPD. This study was conducted on 68 COPD smoker patients and 32 non-COPD smokers who were selected from Chest Department, Faculty of Medicine, Menoufia University during the period from October 2015 to January 2016. A blood sample was taken and a spirometry was performed. Genotyping was performed for nAChRs rs1051730 by SNP assay real time PCR methods. The distribution of nAChRs rs1051730 AA genotypes is more frequent in COPD patients with increase susceptibility to COPD by 5.19 fold. AA genotypes ...
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.