Telferia Occidentalis and Vitamin C Attenuate Phenylhydrazine-Induced Haemolytic Anaemia and Associated Cardio-renal Dysfunctions via Inhibition of Oxidative Stress and Proapoptotic -Protein (Bax) Expressions (original) (raw)

Background The study investigated the modulatory roles of the aqueous leaf extract of Telferia occidentalis, a traditional haematinic, and vitamin C on cardiovascular dysfunction associated with subchronic Phenylhydrazine exposure. Methods Fifty adult male rats were randomly selected and divided into one of five groups of ten animals each: Control; 40 mgkg−1 Phenylhydrazine (PHZ); PHZ with 100 mgkg−1 T.occidentalis; PHZ with 200 mgkg−1 T.occidentalis; and PHZ with 100 mgkg−1 vitamin C. Results Oral exposure of rats to PHZ, without T. occidentalis or vitamin C treatment, resulted in a significant (p<0.05) decrease in the haematological parameters, but increased the blood pressure parameters of rats However, treatment with vitamin C and T. occidentalis leaf extract significantly (p<0.05) ameliorated the aforementioned PHZ-induced alterations of rats haemogram, and blood pressure. Biochemical analysis revealed significant (p<0.05) reduction in the activities of superoxide dism...