In vitro antimicrobial activity of a new antibiotic, MDL 62,879 (GE2270 A) (original) (raw)

MDL 62,879 (GE2270 A) is a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu. MDL 62,879 was very active against gram-positive clinical isolates, particulariy staphylococci and enterococci, for which MICs for 90% of isolates were <0.13 pg/ml. It was equally active against isolates resistant to ji-lactams, erythromycin, gentamicin, and glycopeptides. It also had activity against Mycobacterium tuberculosis. MDL 62,879 had moderate bactericidal activity against staphylococci.