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Case Report: Hodgkin's Lymphoma Syndrome (Atena Editora)
Case Report: Hodgkin's Lymphoma Syndrome (Atena Editora), 2023
Goal: to follow a patient with Hodgkin's Lymphoma syndrome admitted to a teaching hospital. Method: Case report. Results: patient aggravated by the condition of the disease was admitted to the Intensive Care Unit, due to the low of the immune system. Final considerations: the study demonstrated professional and personal growth on the part of the researchers. And for the patient, it improves the quality of life of Hodgkin's Lymphoma carrier.
Hypothalamic dysfunction in a patient with primary lymphoma of the central nervous system
Neurological Sciences, 2012
A 60-year-old woman with no previous history of chronic disease or malignancy presented with intense back and left leg pain and sleep disturbances. The patient had been treated unsuccessfully for the past 6 months with analgetics. Magnetic resonance imaging showed a soft tissue tumor in the L5-S1 region that involved the spinal canal, and a pathohistological analysis of the tumor specimen confirmed the presence of non-Hodgkin, diffuse large B cell lymphoma. After the diagnosis was confirmed, malaise, nausea, and vomiting developed. Multislice computed tomography of the endocranium showed focal infiltration of the hypothalamus and lateral ventricle; dissemination of a systemic lymphoma was excluded. Therapy was initiated as per the De Angelis protocol. After intravenous and intrathecal administration of metotrexate, the patient developed signs of central diabetes insipidus, which responded to therapy with an antidiuretic hormone analog. Despite the obvious infiltration of the hypothalamus, we cannot exclude an idiosyncratic effect of methotrexate on the central diabetes insipidus.
International Journal of Hyperthermia, 2020
Introduction: An abscopal effect is a clinical observation whereby a local treatment is associated with regression of metastatic cancer at a site distant from the primary location of treatment. Here, we describe the clinical systemic effect induced by regional hyperthermia combined with low-dose chemotherapy and provide immunologic correlates. Case presentation: A 15-year-old patient had been diagnosed with alveolar rhabdomyosarcoma (ARMS). All previous treatment options failed in the patient including haploidentical stem cell transplantation and donor lymphocyte infusion. The patient presented with local and metastatic disease, and upon admission, underwent regional hyperthermia combined with low-dose chemotherapy. Immediately following therapy severe skin reactions were observed. Skin biopsies revealed an intraepithelial lymphocytic infiltration dominated by CD3 þ /CD8 þ T cells with a regular network of dendritic cells. Clinical images compared before and during sequential treatment cycles showed complete metabolic response of the local tumor for more than 10 months of therapy. In addition, metastases completely regressed although they were not direct targets of regional hyperthermia. The systemic effect was associated with enhanced frequency of NK cells and T cells expressing the lectin-like natural-killer group 2 D activating receptor (NKG2D), an increase of the CD56 bright subset of NK cells, as well as an increase of effector/memory and effector CD8 þ and CD4 þ T cells in the blood while the percentage of CD25 þ FOXP3 þ regulatory T cells declined. Conclusions: Regional hyperthermia combined with low-dose chemotherapy had the potential to create a systemic effect which was associated with activation of NK cells and T cells.
British Journal of Haematology, 2007
Hodgkin and Reed-Sternberg cells (HRS cells) represent the malignant elements in classical Hodgkin lymphoma (cHL). The origin of these cells was controversial until molecular studies showed their clonality and indicated that in most cases they derive from germinal centre (GC) B-lymphocytes, with only a very small minority (<2%) of cases showing a T-cell pattern (Kuppers et al, 2002). The origin of HRS cells from pre-apoptotic GC B-lymphocytes was further consolidated by the demonstration of the occurrence, in their immunoglobulin genes, of somatic deleterious 'crippling' mutations, which normally determine B-cell apoptosis by hampering high affinity immunoglobulins/B-cell receptors (BCR) expression (Schwering et al, 2003). The reason why, despite their origin, HRS elements survive even without a functional B-cell receptor is still debated (Schwering et al, 2003), and is probably related to HL pathogenesis. In cHL the malignant cells represent only a minor component of the malignancy, which is comprised of a mixed inflammatory infiltrate composed of lymphocytes, eosinophils, neutrophils, fibroblasts, macrophages and plasma cells (Skinnider & Mak, 2002). Several studies have indicated that a disturbed cytokine production contributes to the main
Journal of Clinical Investigation, 1980
explained by infection may occur in patients with malignant lymphoma presumably caused by a release of endogenous pyrogen. Although pyrogen has been found in some tumors with a mixed cell population, production of endogenous pyrogen by the neoplastic cells has not been demonstrated. This report documents the apparently spontaneous synthesis and release of such pyrogen by two human tumor cell lines derived from patients with Hodgkin's disease and histiocytic lymphoma. The endogenous pyrogen from the two cell lines was similar and closely resembled that produced by normal human monocytes in antigenic properties as well as heat and pronase sensitivity. The Hodgkin's disease and histiocytic lymphoma cell lines do not require specific stimulation for the production of endogenous pyrogen suggesting that the mechanism of pyrogen release by neoplastic macrophage-related cells differs from that of normal phagocytic cells. The tumor-associated fever in some patients with malignant lymphoma may be caused by a release of endogenous pyrogen by proliferating neoplastic cells.