Acetylsalicylic Acid Daily vs Acetylsalicylic Acid every 3 days in Healthy Volunteers: Effect on Platelet Aggregation, Gastric Mucosa and PGE2 Synthesis (original) (raw)

2015, Journal of clinical pharmacology

Acetylsalicylic acid has remained as the antiplatelet therapy basis for more than 50 years. Its basic mechanism of action was described more than 40 years ago, and involves irreversible inhibition of the cyclooxygenase enzyme.[1] More recently, further details of acetylsalicylic acid interaction with cyclooxygenase were described (acetylation of serine 529 residue, blocking the arachidonic acid catalytic site, causing strong suppression of prostaglandin-H2 generation and, subsequently, thromboxane-A2 synthesis).[2, 3] On platelets, this will lead to inhibition of platelet activation by the thromboxane receptor, producing an anti-aggregating effect.[4, 5] Daily dosage commonly prescribed for prevention of myocardial infarction, stroke and death for high risk patients is established between 75 and 325 mg per day.[6, 7] This article is protected by copyright. All rights reserved.

Sign up for access to the world's latest research.

checkGet notified about relevant papers

checkSave papers to use in your research

checkJoin the discussion with peers

checkTrack your impact