Survival Time and Prognostic Factors for Breast Cancer among Women in North-East Peninsular Malaysia (original) (raw)
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Survival rate of breast cancer patients in Malaysia: a population-based study
Asian Pacific journal of cancer prevention : APJCP, 2013
Breast cancer is the most common cancer among Malaysian women. Other than hospital-based results, there are no documented population-based survival rates of Malaysian women for breast cancers. This population- based retrospective cohort study was therefore conducted. Data were obtained from Health Informatics Centre, Ministry of Health Malaysia, National Cancer Registry and National Registration Department for the period from 1st Jan 2000 to 31st December 2005. Cases were captured by ICD-10 and linked to death certificates to identify the status. Only complete data were analysed. Survival time was calculated from the estimated date of diagnosis to the date of death or date of loss to follow-up. Observed survival rates were estimated by Kaplan- Meier method using SPSS Statistical Software version 17. A total of 10,230 complete data sets were analysed. The mean age at diagnosis was 50.6 years old. The overall 5-year survival rate was 49% with median survival time of 68.1 months. India...
BMJ Open, 2021
Objective Estimation of the net survival of breast cancer helps in assessing breast cancer burden at a population level. Thus, this study aims to estimate the net survival of breast cancer at different cancer staging and age at diagnosis in the east coast region of West Malaysia. Setting Kelantan, Malaysia. Participants All breast cancer cases diagnosed in 2007 and 2011 identified from Kelantan Cancer Registry. Design This retrospective cohort study used a relative survival approach to estimate the net survival of patients with breast cancer. Thus, two data were needed; breast cancer data from Kelantan Cancer Registry and general population mortality data for Kelantan population. Primary and secondary outcome measures Net survival according to stage and age group at diagnosis at 1, 3 and 5 years following diagnosis. Results The highest net survival was observed among stage I and II breast cancer cases, while the lowest net survival was observed among stage IV breast cancer cases. In...
Asian Pacific journal of cancer prevention : APJCP, 2009
Survival after diagnosis of cancer is one of the major outcome measurements and a key criterion for assessing quality of cancer control related to both the preventive and the therapeutic level. The purpose of this study was to determine the 8-year survival time in Malaysia based on socio-demographic and clinical characteristics. A retrospective study of 472 Malaysian women with breast cancer from the Medical Record Department at University Kebangsaan Malaysia Medical Centre (UKMMC) was therefore performed with survival analysis carried out using the Kaplan-Meier with log-rank test for univariate analysis and Cox-regression for multivariate analysis. Women who had cancer or family history of cancer had a longer 8-year survival time (p = 0.008) compared with others who did not have such a history. Tamoxifen use, positive oestrogen receptor status, and race were prognostic indicators for 8-year survival time (p = 0.036, p = 0.018, p = 0.053, respectively) in univariate analysis. Multiv...
Asian Pacific journal of cancer prevention: APJCP
There is improvement in breast cancer survival in the developed world, but information on breast cancer survival trends in the Asia Pacific region is limited. The aim of the study was to evaluate survival trends and factors that affect survival in Malaysia. Two prospective groups of 423 and 965 newly diagnosed breast cancer patients in University of Malaya Medical Centre, Kuala Lumpur, Malaysia diagnosed in two time periods ie. 1993 to 1997 and in 1998 to 2002 were studied. Vital status was obtained from the National Registry of Births and Deaths. The overall survival was calculated from the date of diagnosis to the date of death from any cause. The survival differences between the two groups were analysed using the log-rank or Peto-Wilcoxon method. Survival estimates and independent prognostic factors were estimated by the Kaplan-Meier method and multivariate analysis using Cox proportional hazard models. P values less than 0.05 were considered statistically significant. Analyses w...
Survival Analysis for Breast Cancer Patients: Case Study at Public Hospital in Malaysia
-Breast cancer is the most frequently occurring cancer as well as the most fatal form of malignancy among Malaysian women. This study aimed to highlight the survival rate of Malaysian breast cancer patients in hope by knowing the pattern of survival and related prognostic factors. This study was conducted using secondary data obtained from a general hospital in Johor Bahru. All 38 cases of breast cancer diagnosed from January 12, 2006 to February 15, 2017 were selected. Age, ethnicity and treatment received were collected to determine prognostic factors. The Chi-square test of independence determines if two variables are independent of one another. Patients' age (p-value = 0.602) and ethnicity (p-value = 0.284) have no association with the survival status of patients while treatment received (p-value <0.001) has association with the patients' survival status. Kaplan-Meier method was used to estimate the survival curves of the breast cancer patients. Patients under 40 years old had a poor survival compared to the patients aged between 41-60 years old and patients above 60 years old. Malay patients tend to have a poorer survival after breast cancer compared to Chinese, Indian and Others ethnic. Patients who received both local and systemic therapy treatment experience death more quickly during the period of study. Log-rank test was used to test the significant difference between the survival experiences of the patients. Treatment group was found to have a significant difference in the survival experience; whereas age group and ethnic group of the breast cancer patients do not have a significant difference in the survival experience.
Breast Cancer Survival at a Leading Cancer Centre in Malaysia
Asian Pacific journal of cancer prevention : APJCP, 2015
GLOBOCAN12 recently reported high cancer mortality in Malaysia suggesting its cancer health services are under-performing. Cancer survival is a key index of the overall effectiveness of health services in the management of patients. This report focuses on Subang Jaya Medical Centre (SJMC) care performance as measured by patient survival outcome for up to 5 years. All women with breast cancer treated at SJMC between 2008 and 2012 were enrolled for this observational cohort study. Mortality outcome was ascertained through record linkage with national death register, linkage with hospital registration system and finally through direct contact by phone or home visits. A total of 675 patients treated between 2008 and 2012 were included in the present survival analysis, 65% with early breast cancer, 20% with locally advanced breast cancer (LABC) and 4% with metastatic breast cancer (MBC). The overall relative survival (RS) at 5 years was 88%. RS for stage I was 100% and for stage II, III ...
FIVE-YEAR SURVIVAL RATE OF BREAST CANCER PATIENTS IN BRUNEI DARUSSALAM
Brunei International Medical Journal, 2019
Introduction: Breast cancer is the most common cancer and leading cause of cancer deaths among women worldwide. In Brunei Darussalam, breast cancer has the highest incidence rate among women. This study presents the survival rate of women diagnosed with breast cancer in Brunei Darussalam and explores the association between survival and demographic or clinical characteristics. Methods: This is a retrospective study of breast cancer diagnosed from 2007 to 2017 among women in Brunei Darussalam. Cancer data was retrieved from population based cancer registry. Kaplan-Meier survival analysis and Log rank test were applied to estimate the survival rates and the association between survival and important patients’ characteristics. Hazard ratios were derived using Cox Proportional Hazard model. Results: The survival rates of breast cancer patients at 1, 3 and 5 years were 89.5%, 79.2% and 72.0% respectively. The 5-year survival rates for cancer stages were 92.2% for localized, 76.9% for regional, and 21.4% for distant metastasis. Ethnicity, cancer stages and cancer stages-morphology interaction were significant independent predictors for breast cancer survival in Brunei Darussalam. Conclusion: The survival rate of women diagnosed with breast cancer in Brunei Darussalam and its significant predictors are similar to those reported from other developed countries. Further studies on predictors such as health seeking behaviours and impact of different cancer treatment will provide further insight in improving survival rates of breast cancer through early cancer detection programmes and strengthening of the healthcare service delivery.
Changing Trends of Breast Cancer Survival in Sultanate of Oman
Journal of Oncology, 2011
Breast cancer is the leading cause of cancer-associated mortality in women, with elevated incidence in developing countries. This retrospective study included all 122 patients diagnosed with breast cancer from January 2003 to December 2008 in the Sultanate of Oman. Age at presentation was 47.41 years (SD±12.88), with one-third of patients younger than 40 years. The majority of patients presented with stage III (41.2%) and IV (18.2%) breast cancer. T size (P = .023), skin involvement (P = .003), and stage at presentation (P = .004) were significantly associated with overall survival. Skin involvement at presentation (P = .003), T size (P = .09), lymph node status (P = .013), and stage (P = .003) were strong predictors of relapse-free survival. Patients had a 5-year survival of 78%, compared to 64% of breast cancer patients diagnosed between 1996 and 2002 identified in our previously published study. Thus, despite Omani breast cancer patients continuing to present with advanced breast cancer, survival rates have significantly improved.
2019
Introduction: Breast cancer is the most common cause of cancer death among women. The purpose of this study is to determine the 5-years survival rate and prognostic factors among breast cancer patients in a tertiary oncological centre in Penang, Malaysia. Methods: A retrospective cohort study was conducted at the Advanced Medical and Dental Institute, Universiti Sains Malaysia. All 214 cases of breast cancer diagnosed from 1st January 2008 until 31st December 2012 were selected and retrospectively followed-up until 31st December 2017. The survival status for this study was referring to the record of the National Registration of Malaysia. Kaplan-Meier with Log-rank test and Cox regression were used for the univariable and multivariable analysis, respectively. Results: The mean (SD) age at diagnosis was 50.98 (±10.75) years. The majority of the patients were Malay (55.7%) and married (96.5%). After controlling for the effect of underlying comorbidities, lymph nodes involvement, marita...
Epidemiology of breast cancer in Malaysia
Asian Pacific Journal of Cancer …, 2006
Breast cancer is the commonest cancer in women in most parts of the world. The number of newly diagnosed cases in the year 2002 was estimated to be more than a million, and there were more than 400,000 deaths worldwide. There is a marked geographical variation, with the highest incidence in northern Europe and North America, intermediate in southern Europe and South America and lowest in Africa and Asia (Figure 1). The age-standardised incidences range from 95 per 100,000 in the more developed countries to 20 per 100,000 in those less developed (Parkin et al., 2005). In Asia, there has been a rapid increase in the incidence of breast cancer in recent years, and the disease may occur at a relatively young age (Moore et al., 2003). As well as the large variation in the incidence, there is also a wide variation in the mortality and survival between different countries and regions and also within specific populations. Many complex factors underlie these variations, including population structure (age, race, and ethnicity), lifestyle, environment, socioeconomic status, risk factor prevalence, mammography use, disease stage at diagnosis,