Pharmaceutical applications of biotechnology: promise and reality Editorial overview On to development and commercialization (original) (raw)

ROLE OF BIOTECHNOLOGY IN PHARMACEUTICAL RESEARCH: A COMPREHENSIVE REVIEW

INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES , 2020

Biotechnology is a multidisciplinary scientific research field which uses living organisms or their parts to develop or modify products, or improve plants, animals and microorganisms. Biotechnology and the world of colors are always connected with each other through biotech applications. This has encouraged the requirement to construct a classification system based on colors. Advance technologies and products are developed within the areas include medicine (development of new medicines and therapies), agriculture (development of genetically modified plants, biofuels, biological treatment) or industrial biotechnology (production of chemicals, paper, textiles and food), environment (maintenance of biodiversity, bioremediation) etc. However, Biotechnology achieved considerable progress in the branch of healthcare sector. Pharmaceutical biotechnology is a relatively new and growing field in which the principles of biotechnology are applied to the development of drugs. A majority of therapeutic drugs in the current market are bioformulations, such as antibodies, nucleic acid products and vaccines. Biotechnology helps the pharmaceutical industry to develop new products, new processes, methods and services and to improve existing ones. This article is an inclusive review of use of biotechnology in the development of novel pharmaceutical products. It also covers the impact of biotechnology in research and invention related to different aspects of medicine. There is a widespread list of biopharmaceutical products in healthcare management available for therapeutic use. In this review we are discussed about various classes of biotechnology-based products such as gene therapy, monoclonal antibody, DNA fingerprinting, vaccines, biopharmaceuticals, stem cell therapy, pharmacogenomics along with their therapeutic applications.

Biotechnology-derived medicines: What are they? A pharmacological and a historical perspective

Journal of Generic Medicines, 2010

Biologicals, that is, medicines obtained from living organisms, are not new. History provides many examples of animal or human extracts being used to prevent or treat human diseases. Physicians have thus been aware for centuries of the therapeutic value of our own molecules. The difficulty laid many times in how to obtain these self or self-like compounds. Biotechnology - a technology by which manipulated living organisms are utilized to generate useful products such as drugs - provided a revolutionary answer. We know how to genetically engineer bacteria, yeast, insect or mammalian cells to synthesize human molecules, the so-called human recombinant therapeutic proteins. Murine and humanized monoclonal antibodies against human antigens are also biotechnological products. The number of biotechnological drugs being marketed, and those in clinical trials or awaiting authorization, is growing exponentially. We are now still on the beginnings of a new era in pharmacotherapy of which it i...

Two decades of publishing excellence in pharmaceutical biotechnology

Journal of pharmaceutical sciences, 2015

Recombinant biological products have revolutionized modern medicine by providing both remarkably effective vaccines to prevent disease and therapeutic drugs to treat a wide variety of unmet medical needs. Since the early 1980s, dozens of new therapeutic protein drugs and macromolecular vaccines have been commercialized, which have benefitted millions of patients worldwide. The pharmaceutical development of these biological products presented many scientific and technical challenges, some of which continue today with newer candidates including recombinant protein-based vaccines with novel adjuvants, peptide and RNA-based drugs, and stem cellular therapies. Compared with small molecule drugs, the characterization, stabilization, formulation, and delivery of biomolecules share common hurdles as well as unique challenges. This area of drug development research has been referred to as "pharmaceutical biotechnology", in recognition of the critical role that recombinant DNA technology plays in the design and production of most of these biological products. Current research focus areas in this field include (i) determination of structural integrity of the primary sequence, post-translational modifications, and higher-order three dimensional shapes, (ii) assessment of physicochemical degradation pathways and their effects on biological activity and potency, (iii) formulation design and development to optimize stability and delivery, (iv) evaluating and optimizing process development steps