Study of the Incidence, Clinicopathological Profile, and Management of Second Primary Tumors in Patients with Index Head and Neck Tumors (original) (raw)
Related papers
Impact of Second Primary Tumors on Survival in Head and Neck Cancer: An Analysis of 2,063 Cases
The Laryngoscope, 2008
Objective/Hypothesis: To investigate the impact of second primary tumors on prognosis for patients with head and neck squamous cell carcinoma (HNSCC). Study Design: Prospectively recorded data on HNSCC patients treated at an academic tertiary referral center. Methods: An analysis of 2,063 patients treated over a 15 year period for tumors of the upper aerodigestive tract, with a minimum follow-up of 10 years. Results: A total of 351 (17%) patients developed a second primary, mean time to diagnosis of the second tumor being more than 4 years from the date of the initial tumor. Median overall survival from the date of the first tumor among patients who later developed a second primary was 6 years versus 3 years among all other patients (P Ͻ .05). During the first 6 years after treatment of the initial tumor, cancer specific survival was better in the second primary group. After diagnosis of a second primary tumor, median survival was 12 months. A positive correlation was found between second primaries and stage I/II primary disease, low patient age, and initial tumors of the larynx and oral cavity. Conclusions: The group of patients with the highest risk of a second primary tumor was younger patients with limited initial tumors. A high proportion of patients who later developed a second primary were complete responders after treatment of the first tumor. However, prognosis was poor after the actual diagnosis of the second primary tumor.
Second Primary Tumors in Patients with Head and Neck Cancer
Current Oncology Reports, 2011
This is a review on second primary tumors in patients with head and neck cancer. These patients have a high risk of developing other cancers simultaneously or subsequently. The incidence of multiple primary tumors in this population can be as high as 27%. Recurrences are the most common cause of treatment failure within the first 2 years of follow-up. After the third year the diagnosis of a second primary tumor becomes the most important cause of morbimortality in head and neck cancer patients, especially in those treated for cancers early diagnosed. Most second primary tumors occur in the upper aerodigestive tract (40%-59%), lung (31%-37.5%), and esophagus (9%-44%). Patients who develop second primary tumor have a significant reduction of survival expectancy.
Factors associated with the development of second primary tumours in head and neck cancer patients
European Journal of Cancer Care
Introduction: The development of second primary tumours (SPTs) is one of the main causes of low survival in patients with head and neck cancer (HNC). The aim of this study was to review the evidence about factors associated with developing SPTs in patients with HNC. Methods: An updated systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, and the search was performed in Pubmed and Scopus. Only original articles with a cohort or casecontrol design were included. Article quality was assessed with the Newcastle-Ottawa scale. Results: Thirty-six and two case-control studies were included, with quality medium (n = 5) to high (n = 33). Tobacco showed a significant association with SPT development, with risks ranging from 1.41 (95%CI: 1.04-1.91) to 5.52 (95%CI: 2.91-10.49). Regarding alcohol, risks ranged from 1.46 (95%CI: 1.12-1.91) to 21.3 (95%CI: 2.9-156). Location of the index tumour in the hypopharynx/oropharynx, absence of human papillomavirus and presence of a premalignant lesion also increased the risk of SPTs. More controversy was found for sex, age and other clinical factors of the tumour. Conclusion: Toxic lifestyle habits and clinical factors were associated with the risk of SPTs in HNC patients. These findings may improve individualised prevention strategies in its follow-up. K E Y W O R D S head and neck cancer, second primary tumours 1 | INTRODUCTION Head and neck cancer (HNC) has a significant burden worldwide. This heterogeneous group of tumours (including lip, oral cavity, larynx and pharynx) occupies the eighth position in incidence worldwide, with 858,348 new cases in 2020, that is up to 4.6% of all cancers (Sung et al., 2021). Last trends indicate an expected incidence increase in
A Retrospective Evaluation of Clinical Profile of Second Primary Head and Neck Cancer
Journal of clinical and diagnostic research : JCDR, 2016
Incidence of Second Primary Malignancy (SPM) after successful treatment of primary is increasing and may cause the problem for optimal treatment. This study was conducted retrospectively to analyse incidence, disease free survival between malignancies, pattern of treatment and outcome. Sixteen out of 22 patients of previously treated cases of head and neck cancer those develop SPM of head and neck region managed over a period of January 2012 to December 2015 in Department of Radiotherapy-II, Pt. BD Sharma PGIMS, Rohtak were analyzed retrospectively. Sixteen patients with unresectable disease were given reirradiation with external beam radiotherapy. Median age of presentation of first malignancy was 27 years (Ranged 26 -65 years), whereas median age was 60 years for second malignancy (range 45-71 years). All patients were smokers during first malignancy; 87.5% (14/16) had historyof smoking during second malignancy. Oropharynx (50%) was most common site of presentation of primary tumo...
Second primary malignancies in patients with cancer of the head and neck
Otolaryngology-head and Neck Surgery, 2003
OBJECTIVE: Clinical study of second primary malignancies (SPM) in patients with cancer of the head and neck (HNC). STUDY DESIGN AND SETTING: Retrospective study over 48 patients with SPMs culled from 636 with HNC seen in 122 months. The minimum follow-up was 18 months, and the setting for the study was the institutional referral center. RESULTS: There was association between the sites of first and second tumor. The SPMs were diagnosed with a constant rate throughout the period of study. Five year-survival rate was 29%. SPM in an advanced stage either outside of the head and neck or synchronous had poor survival. CONCLUSION: The SPMs are a growing problem with better survival after treatment of the first malignancy. SIGNIFICANCE: Regular follow-up is necessary in HNC patients to improve their survival, giving special attention to the development of SPM.
Second Primary Tumors in Head and Neck Cancer Patients
Acta Oto-laryngologica, 2002
Objective: Head and neck cancer survivors have increased risk of developing second primary tumors compared to overall population. Because second primary represent a major cause of morbidity and mortality in this population, early detection is fundamental. Materials and methods: In this 10-years single-institution study we investigated: incidence, clinicalpathological risk factors and survival of patients with second primary tumor. We included all patients with diagnosis of squamous cell carcinoma of the head and neck seen at the Modena University Hospital from 2008 to 2018. Results: Among 1177 patients included, 222 (18.9%) developed second primary tumor; its survival probability at 5 years was 40.6%. Alcohol consumption (p=0.0055) and index cancer in oropharynx (p=0.0029), supraglottic larynx (p=0.0000), glottic larynx (p=0.0222) were associated with higher risk of second primary. The most common second primary sites were head and neck district and lung (70, 31.5% and 67, 30.2%, respectively). Head and neck district were more common in oral cavity (18, 43%) and oropharynx index cancer (20, 31%); lung second primary in hypopharynx (4, 40%), supraglottic larynx (17, 43%) and glottic larynx index cancer (23, 35%). Conclusion: Head and neck cancer survivors developing a second primary tumor have dismal prognosis. Tailored surveillance is recommended. Clinical correlations and long-term follow-up in 100 patients with sarcoglycanopathies Running title: Long-term follow-up in sarcoglycanopathies
ORL, 2016
Background/Aims: Patients with head and neck squamous cell carcinoma (HNSCC) are at risk for second primary malignancies (SPMs). The prevalence, distribution, and patient survival in head and neck versus non-head and neck SPMs are not fully elucidated. The objective of this study was to quantify the rate of SPMs in patients with HNSCC. Methods: This is a population-based cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Prevalence and location of SPMs, and survival data were analyzed. Results: There were 58,363 HNSCC patients, and the prevalence of HNSCC and non-HNSCC SPMs was 3.0% (1,746) and 8.8% (5,109), respectively. Overall survival (OS) was higher in patients with HNSCC SPMs compared to non-HNSCC SPMs (p < 0.001), with no difference in disease-specific survival. Patients with SPMs in the lung and esophagus had a worse OS (p < 0.001), and patients with SPMs in the prostate and breast had a better OS (p < 0.001). Conclusion: In HNSCC pa...
The risk of second primary tumors in head and neck cancer: A systematic review
Head & neck, 2019
Background: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up. This article was written by members of the International Head and Neck Scientific Group (www.IHNSG.com).
Clinicopathological study of secondaries in neck in relation to head & neck malignancies
IP innovative publication pvt. ltd, 2019
Cervical metastasis is the most critical prognostic factors in head and neck carcinoma. Accurate detection and measurement of metastases is important for precise staging of patients with head and neck cancers because it determines treatment strategy. Materials and Methods: This cross-sectional study was carried out on 110 patients, presenting with neck secondaries with head and neck malignancy (primary and occult) in the Department of ENT, N.S.C.B.MCH, Jabalpur from March 2016 to August 2017. Results: Head and neck carcinoma with neck secondaries is more common in males (M: F=6:1). Oral carcinoma was commonest followed by carcinoma larynx & majority with unilateral (left>right) neck node metastasis, Level II being the commonest. Most common Histopathology of primary was SCC and FNAC of neck node was metastatic deposits of SCC. Majority presented at stage IV. Conclusions: It is concluded that patients usually present to a tertiary care centre at advanced stages, with locally as well as extensive metastatic spread. This can be attributed to lack of awareness and unavailability of proper medical facilities in rural population. There should be health education in community about carcinogenic substances, to reduce the burden of carcinomas & proper medical facilities in low socioeconomic strata. Pathological investigations are gold standard diagnostic modalities for head & neck carcinoma and neck node metastases, not only for confirmation but also for proper further management.
Second Malignant Neoplasms in Patients with Head and Neck Squamous Cell Carcinomas
Acta Oncologica, 1993
The incidence of second malignant neoplasms (SMN) was analyzed in 714 patients with squamous cell carcinomas of the oral cavity, oropharynx, hypopharynx and larynx. With a minimum follow-up of 3.5 years and 2 540 person-years at risk 84 SMN (10 synchronous and 74 metachronous) developed in 81 patients. The relative risk of S M N was 2.4. The actuarial method showed an annual incidence of SMN of 3.5%. For oral cavity and oropharyngeal tumors the annual incidence of SMN was 4.0% and 3.8% respectively, compared to 2.10/0 for laryngeal cancer (p < 0.013 and 0.017 respectively). Sex, age or stage of the index tumor did not significantly influence the annual incidence of SMN. After 3 years of follow-up, SMN became more a cause of concern than loco-regional relapse.