Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits (original) (raw)
Related papers
Cardioprotective Activity Of Herbal Formulation In Experimental Animal
American Journal of PharmTech Research
The present study was designed to investigate the cardioprotective effects of herbal formulation in rats with isoproterenol-hydrochloride (ISPH) induced myocardial infraction. Adult male Wistar Albino rats were pre-treated with herbal formulation daily for a period of 4 weeks. After the treatment period, ISPH (85 mg/kg) was subcutaneously injected into the rats at 24 h intervals for 2 days. ISPH induced myocardial damage indicated by cardiac marker enzyme activities including creatine kinase-MB, lactate dehydrogenase, SGOT, angiotensin converting enzyme. The activities of antioxidant enzymes such as superoxide dismutase were significantly decreased in hearts after ISPH-induced myocardial infraction. However, pre-treatment of ischemic rats with herbal formulation brought the biochemical parameters to near normalcy, indicating the protective effect of herbal formulation against ISPH-induced ischemia in rats.
Efficacy of herbal mixture for the treatment of salbutamol induced myocardial necrosis in rabbits
Pakistan Veterinary Journal, 2015
Received: Revised: Accepted: August 18, 2014 May 18, 2015 June 20, 2015 The current investigation was design to develop safer, efficacious and viable cardioprotective and antilipidemic herbal mixture to control cardiovascular diseases as new alternatives of synthetic drugs. Four medicinally valuable plants Terminalia arjuna (T), Rauvolfia serpentina (R), Elettaria cardamomum (C) and Crataegus oxyacantha (Cr) were selected for this study. Mixture of plants T, R, C, Cr was prepared with ratio 1:2:1:1 respectively. Both preventive and curative effects of plant mixture were studied. In preventive mode of treatment, rabbits were pretreated with plant mixture after that cardiotoxic compound was given. In curative mode of treatment, first cardiotoxicity was induced in rabbits then these cardio-intoxicated rabbits were treated with plant mixture. Cardiac marker enzymes, lipids profile and antioxidant enzymes were determined in experimental animals. Rabbits administrated with salbutamol (G-I...
Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress
Oxidative medicine and cellular longevity, 2018
In this research work, the antioxidant and metabolomic profiling of seven selected medicinally important herbs including,,,,,, andwas performed. Thecardioprotective potential of these medicinal plants was evaluated against surgically induced oxidative stress through left anterior descending coronary artery ligation (LADCA) in dogs. The antioxidant profiling of these plants was done through DPPH and DNA protection assay. Theandshowed maximum antioxidant potential, while theshowed poor antioxidative strength even at its high concentration. Different concentrations of extracts of the said plants exhibited the protection of plasmid DNA against HOdamage as compared to the plasmid DNA merely treated with HOThe metabolomic profiling through LC-MS analysis of these antioxidants revealed the presence of active secondary metabolites responsible for their antioxidant potential. Duringanalysis, blood samples of all treatment groups were drawn at different time intervals to analyze the cardiac a...
Cardioprotective Herbal Plants: A Review
International Journal for Research in Applied Science & Engineering Technology (IJRASET), 2023
Plants play a vital role in providing food and various essential needs of human since beginning of human race,let it be the basic needs to medicinal drugs for well being and progress towards health of an human race as the time has past human had progress in medicial field.Progress in technology has driven human race to higher progression in lesser time as progress is rapid it has given birth to various cardiological disease and to cure them various synthetic cardiac drugs have been used. To overcome and keep cardiac health of humans protected from drugs humans have turn back to nature to and use of phtoconstituents is increased A number of bioactive compounds found in cardioprotective plants, such as antioxidants, flavonoids, anthocyanin, tannins, ellagic acid, terpenoids, carbohydrates, have been shown to improve cardioprotection and thus reduce the risk of cardiac disorders.Purpose of this review article is to provide and educate individuals about drugs present in nature and include in daily diet to enhance there cardiac health and damage cause due to synthetic drugs.
Cardioprotective Potential of Plant-Derived Molecules: A Scientific and Medicinal Approach
Dose-Response, 2019
Since the beginning of human civilization, plants have been used in alleviating the human distress and it was recorded for about thousands of years ago that the plants are being used for medicinal purposes. Natural bioactive compounds called phytochemicals are obtained from medicinal plants, vegetables, and fruits, which functions to combat against various ailments. There is dire need to explore the plant biodiversity for its medicinal and pharmacological potentials. Different databases such as Google scholar, Medline, PubMed, and the Directory of Open Access Journals were searched to find the articles describing the cardioprotective function of medicinal plants. Various substances from a variety of plant species are used for the treatment of cardiovascular abnormalities. The cardioprotective plants contain a variety of bioactive compounds, including diosgenin, isoflavones, sulforaphane, carotinized, catechin, and quercetin, have been proved to enhance cardioprotection, hence reduci...
A Review Article on Current Pharmacological Status of Cardioprotective Plant
Current research in Pharmaceutical sciences., 2023
Cardiovascular diseases involve abnormalities of the heart and blood vessels, such as coronary heart disease, hypertension, and cerebrovascular disease, and are the main cause of the increase in mortality rate in the world. Herbal plants tend to be very useful to prevent cardiovascular disease. The phytoconstituents of herbal medicinal plants like tannins, alkaloids, saponins, flavonoids, and glycosides that have the ability to prevent cardiovascular diseases. Examples such as Nerium oleander, Amaranthus viridis, Ginkgo biloba, Daucus carota, Gingerol, Tinospora cordifolia etc. Many studies investigated the cardioprotective effect of these natural products against experimentally-induced myocardial damage, and their results revealed that their potential phytochemicals exhibited significant antioxidant, anti-apoptotic, anti-inflammatory, anti-atherosclerotic activities. The review highlights the promising mechanisms and probable applications of various herbal plants, and their phytochemicals in the prevention and treatment of cardiovascular diseases. The cardioprotective plants contain a wide-variety of bioactive compound involve with diosgenin, isoflavones, sulforaphane, carotinized, catechin and quercetin are increasing the cardio protection and decreases the chances of cardiac abnormalities.
Cardioprotective and other beneficial effects of some Indian medicinal plants
Journal of Clinical Biochemistry and …, 2006
The distinguishing feature of the traditional Indian medicinal system, Ayurveda, is its emphasis on the maintenance of positive health. As per Ayurveda, Indian medicinal plants are rich sources of substances that have several therapeutic properties including cardioprotection. Globally, cardiovascular diseases are a leading cause of mortality. Several epidemiological studies suggest a correlation between antioxidant intake and occurrence of various cardiovascular diseases. This review deals with medicinal plants which possess cardiotonic, cardioprotective and antioxidant effects. It also includes our studies on the antioxidant properties of some of these plants such as Terminalia arjuna (arjun), Trigonella foenum-graecum (fenugreek), Curcuma longa (turmeric), Garcinia indica (kokum) and Vitis vinifera (grapes). Among these, Terminalia arjuna possesses the highest antioxidant potential and inhibit whole plasma oxidation in rats besides showing significant intestinal absorption. Other plants studied also exhibit radical scavenging effects as studied using various biochemical assays. These antioxidant effects may possibly be responsible for their known beneficial therapeutic effects including their use in cardioprotection.
Journal of environmental biology / Academy of Environmental Biology, India, 2011
Commiphora mukul commonly known as Guggul is one of the oldest and commonly consumed herb for promoting heart and vascular health. Present study was undertaken to evaluate cardioprotective potential of Commiphora mukul against isoprenaline-induced myocardial necrosis in rats. Wistar albino rats were divided into three main groups: sham (saline only), isoprenaline control (saline and isoprenaline) and Commiphora mukul treated (Commiphora mukul and isoprenaline) groups. Commiphora mukul was administered in three doses 100, 200 and 400 mg kg(-1) p.o. for 30 days. On 29th and 30th day, the animals of isoprenaline control and Commiphora mukulpretreatment groups were administered isoprenaline (85 mg kg(-1); s.c.), consecutively at an interval of 24 hr. Isoprenaline administration produced a significant (p < 0.05) decrease in myocardial antioxidants; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), reduced glutathione (GSH), and myocyte injury marker enzymes c...
Anti-oxidative stress effects of Herba leonuri on ischemic rat hearts
Life Sciences, 2005
Our current study was to test the hypothesis that the extract of Herba leonuri (HL) would have antioxidant and cardioprotective effects on ischemic myocardium. The extract of HL (400 mg/kg/day) was administered orally (daily) starting from 1 week before and continuing until 3 weeks after myocardial infarction (MI). Surviving rats were sacrificed at different time points to obtain left ventricles for biochemical assays. Our study demonstrates for the first time that HL does have antioxidant effects both in vitro and in vivo. The antioxidant effects of HL are exerted only under the condition of oxidative stress, by selectively preserving the activities of superoxide dismutase and glutathione peroxidase, as well as depressing the formation of malondialdehyde, especially in the acute phase of acute MI. Its effects of scavenging free radicals and inhibiting the formation of reactive oxygen species may play a key role in protecting the endogenous antioxidant system from oxidative stress in vivo. D
Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review
Evidence-based Complementary and Alternative Medicine, 2022
Cardiovascular diseases (CVDs) are the world's leading killers, accounting for 30% deaths. According to the WHO report, CVDs kill 17.9 million people per year, and there will be 22.2 million deaths from CVD in 2030. +e death rates rise as people get older. Regarding gender, the death rate of women by CVD (51%) is higher than that of men (42%). To decrease and prevent CVD, most people rely on traditional medicine originating from the plant (phytochemicals) in addition to or in preference to commercially available drugs to recover from their illness. +e CVD therapy efficacy of 92 plants, including 15 terrestrial plants, is examined. Some medicinal plants well known to treat CVD are, Daucus carota, Nerium oleander, Amaranthus Viridis, Ginkgo biloba, Terminalia arjuna, Picrorhiza kurroa, Salvia miltiorrhiza, Tinospora cordifolia, Mucuna pruriens, Hydrocotyle asiatica, Bombax ceiba, and Andrographis paniculate. +e active phytochemicals found in these plants are flavonoids, polyphenols, plant sterol, plant sulphur compounds, and terpenoids. A general flavonoid mechanism of action is to prevent low-density lipoprotein oxidation, which promotes vasodilatation. Plant sterols prevent CVD by decreasing cholesterol absorption in the blood. Plant sulphur compound also prevent CVD by activation of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) and inhibition of cholesterol synthesis. Quinone decreases the risk of CVD by increasing ATP production in mitochondria while terpenoids by decreasing atherosclerotic lesion in the aortic valve. Although several physiologically active compounds with recognized biological effects have been found in various plants because of the increased prevalence of CVD, appropriate CVD prevention and treatment measures are required. More research is needed to understand the mechanism and specific plants' phytochemicals responsible for treating CVD.