Synergistic Anticancer Potential of Artemisinin When Loaded with 8-Hydroxyquinoline-Surface Complexed-Zinc Ferrite Magnetofluorescent Nanoparticles and Albumin Composite (original) (raw)
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ACS Applied Nano Materials, 2018
Fabrication of novel magnetofluorescent nanoparticles by complexation of zinc ions present on the surface of zinc ferrite nanoparticle (ZnFe2O4 NP) with 8-hydroxy-2quinolinecarboxaldehyde (HQCald) is reported. The as prepared HQCald-complexed ZnFe2O4 NPs showed good quantum yield (3.62%), high photostability, considerable excited state lifetime (5.31 ns) and high saturation magnetization (12.7 emu g-1). These magnetofluorescent nanoparticles demonstrated bioimaging capability both at the ensemble and single particle levels, and in vitro magnetic targeting. Moreover, the pronounced anti-proliferative efficacy of these
2008
Controlling the magnetic properties of a nanoparticle efficiently via its particle size to achieve optimized heat under alternating magnetic field is the central point for magnetic hyperthermia-mediated cancer therapy (MHCT). Here, we have shown the successful use of stevioside (a natural plant-based glycoside) as a promising biosurfactant to control the magnetic properties of Fe 3 O 4 nanoparticles by controlling the particle size. The biocompatibility and cellular uptake efficiency by rat C6 glioma cells and calorimetric magnetic hyperthermia profile of the nanoparticles were further examined. Our finding suggests superior properties of stevioside-coated magnetite nanoparticles in comparison to polysorbate-80 and oleic acid coated nanomagnets as far as particle size reduction, biocompatibility, hyperthermic effect, and cellular uptake by the glioblastoma cancer cells are concerned. The stevioside-coated nanomagnets exhibiting the maximum temperature rise were further investigated as heating agents in in vitro magnetic hyperthermia experiments (405 kHz, 168 Oe), showing their efficacy to induce cell death of rat C6 glioma cells after 30 min at a target temperature T ¼ 43 C.
International Journal of Materials, Mechanics and Manufacturing, 2017
Nowadays there is a tremendous shift in focus towards developing controlled drug delivery systems using drug-loaded nanomaterials. Of the many available systems, magnetic nanoparticles are considered promising drug-carriers due to their large surface area, ease of synthesis, low toxicity and imaging capability. Herein, we report a simple approach to create a novel chemotherapeutic formulation made of fluorescently-labeled PVPylated magnetic iron oxide nanoparticles loaded with anticancer drugs. Drug loading and release profiles were first studied, showing high loading drug efficiencies and relatively fast release of the cargo from its construct. The delivery of these particles to cancerous cells were then investigated. Whereas the Fl-PVP-MNPs were not toxic to the tested cancerous cells even at high doses, the cells were sensitive to Dox-loaded Fl-PVP-MNPs, effectively killing the cells. We anticipate that the observed potent effect is due to the successful intracellular uptake of the MNPs by cells and the subsequent release of Dox from the NPs, which can then translocate to the nucleus and exert its cytotoxic action. Notably, the MNPs used in this work can potentially open new opportunities for in vivo cancer therapeutic imaging and hyperthermia.
Journal of Colloid and Interface Science, 2014
The magnetic nanoparticles attract increasing interest due to their opportunities in cancer therapy and used as drug carriers for several other diseases. The present study investigates the quercetin conjugated superparamagnetic Fe 3 O 4 nanoparticles for in-vitro analysis of breast cancer cell lines for chemotherapy. A simple precipitation method was used to prepare the dextran coated Fe 3 O 4 nanoparticles and the anticancer flavonoid quercetin was conjugated on the surface via carboxylic/amine group using nanoprecipitation method. The structural, morphological and the magnetic properties of the prepared materials were studied by using X-ray diffractometer (XRD), Fourier transformed infer-red spectrometer (FTIR), transmission electron microscope (TEM) and vibrating sample magnetometer (VSM). The MTT (3-(4,5dimethylthiahiazol-2-yl)-2,5-diphenyl tetrazolium) assay of dextran coated Fe 3 O 4 nanoparticles did not exhibit notable toxicity against MCF7 cells, whereas the cytotoxicity of quercetin conjugated Fe 3 O 4 nanoparticles increased significantly in comparison with pure quercetin. The incubation of MCF-7 cells with quercetin conjugated Fe 3 O 4 nanoparticles (QCMNPs) shows significant changes in cellular morphology observed through fluorescent microscopy. The results validate the prepared quercetin conjugated Fe 3 O 4 nanoparticles are promising anticancer agents for targeted drug delivery.
Nanomedicine (London, England), 2017
Recent advances in the development of magnetic nanoparticles (MNPs) have shown promise in the development of new personalized therapeutic approaches for clinical management of cancer patients. The unique physicochemical properties of MNPs endow them with novel multifunctional capabilities for imaging, drug delivery and therapy, which are referred to as theranostics. To facilitate the translation of those theranostic MNPs into clinical applications, extensive efforts have been made on designing and improving biocompatibility, stability, safety, drug-loading ability, targeted delivery, imaging signal and thermal- or photodynamic response. In this review, we provide an overview of the physicochemical properties, toxicity and theranostic applications of MNPs with a focus on magnetic iron oxide nanoparticles.
Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy
Biomaterials, 2010
The primary inadequacy of chemotherapeutic drugs is their relative non-specificity and potential side effects to the healthy tissues. To overcome this, drug loaded multifunctional magnetic nanoparticles are conceptualized. We report here an aqueous based formulation of glycerol monooleate coated magnetic nanoparticles (GMO-MNPs) devoid of any surfactant capable of carrying high payload hydrophobic anticancer drugs. The biocompatibility was confirmed by tumor necrosis factor a assay, confocal microscopy. High entrapment efficiency w95% and sustained release of encapsulated drugs for more than two weeks under in vitro conditions was achieved for different anticancer drugs (paclitaxel, rapamycin, alone or combination). Drug loaded GMO-MNPs did not affect the magnetization properties of the iron oxide core as confirmed by magnetization study. Additionally the MNPs were functionalized with carboxylic groups by coating with DMSA (Dimercaptosuccinic acid) for the supplementary conjugation of amines. For targeted therapy, HER2 antibody was conjugated to GMO-MNPs and showed enhanced uptake in human breast carcinoma cell line (MCF-7). The IC 50 doses revealed potential antiproliferative effect in MCF-7. Therefore, antibody conjugated GMO-MNPs could be used as potential drug carrier for the active therapeutic aspects in cancer therapy.
Nanotechnology had found its leading edge in medicine and pharmaceutical sciences through disease detection, controlled drug delivery and targeted drug therapy, in tissue engineering utilising biosensors, nanorobots and so on. With the recent developments in nanotechnology, magnetic nanoparticles (MNPs) have gained significant attention to the pharmaceutical formulators due to their biocompatibility, flexibility of surface modification and ability to function at the cellular and molecular level of biochemical interactions. MNPs are commonly composed of magnetic elements, such as iron, nickel, cobalt and their oxides like magnetite. There are different methods involved for the preparation of MNPs like co-precipitation, thermal decomposition, microemulsion, sol-gel reaction, etc. The wide spread application of MNPs in diagnosis & therapy include contrast agents in magnetic resonance imaging (MRI), drug/gene carriers for different kinds of therapeutic agents, tissue repair, hyperthermia, immunoassay, and cell separation/sensing. Magnetoliposomes find their uses for magnetic hyperthermia as controlled & targeted drug delivery systems in cancer therapy. The self assembling characteristics of PF127, an amphiphilic polymer, coated on MNPs have been extensively explored in the form of micelles for controlled drug delivery applications. In this study, an attempt has been made to explore different applications where MNPs have been designed and reported as strategic tools for detection, diagnosis, controlled drug delivery and targeted drug therapy.
Advances in the Synthesis and Application of Magnetic Ferrite Nanoparticles for Cancer Therapy
Pharmaceutics
Cancer is among the leading causes of mortality globally, with nearly 10 million deaths in 2020. The emergence of nanotechnology has revolutionised treatment strategies in medicine, with rigorous research focusing on designing multi-functional nanoparticles (NPs) that are biocompatible, non-toxic, and target-specific. Iron-oxide-based NPs have been successfully employed in theranostics as imaging agents and drug delivery vehicles for anti-cancer treatment. Substituted iron-oxides (MFe2O4) have emerged as potential nanocarriers due to their unique and attractive properties such as size and magnetic tunability, ease of synthesis, and manipulatable properties. Current research explores their potential use in hyperthermia and as drug delivery vehicles for cancer therapy. Significantly, there are considerations in applying iron-oxide-based NPs for enhanced biocompatibility, biodegradability, colloidal stability, lowered toxicity, and more efficient and targeted delivery. This review cove...
Journal of Chemical Sciences, 2015
Superparamagnetic iron oxide nanoparticles were synthesized by simple co-precipitation method and modified with different coating agents such as ascorbic acid, hexanoic acid, salicylic acid, L-arginine and L-cysteine. The synthesized nanoparticles were characterized by various techniques such as FT IR, XRD, VSM, SEM, TEM and thermal analysis. Both bare and coated magnetites were of cubic spinel structure and spherical in shape. All the magnetite nanoparticles showed superparamagnetic behaviour with high saturated magnetization. In vitro cytotoxicity test of bare and coated nanoparticles was performed using adenocarcinoma cells, A549. Cell viability of bare and L-arginine coated magnetite nanoparticles showed IC 50 value of 31.2 µg/mL proving the compatibility of nanocarriers when compared to others. Hence, L-arginine coated nanoparticles were used for loading the drug paclitaxel and the observed IC 50 value (7.8 µg/mL) shows its potent anti-proliferative effect against A549 lung cancer cell lines. Thus, it can be speculated that the drug paclitaxel loaded L-arginine coated nanoparticles could be used as an effective drug carrier for the destruction of cancer cells.