Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice (original) (raw)

Antimicrobial Cathelicidin Peptide LL-37 Inhibits the LPS/ATP-Induced Pyroptosis of Macrophages by Dual Mechanism

Isao Nagaoka

PLoS ONE, 2014

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Therapeutic Potential of Cathelicidin Peptide LL-37, an Antimicrobial Agent, in a Murine Sepsis Model

Isao Nagaoka

International Journal of Molecular Sciences, 2020

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Therapeutic Action of Antimicrobial Cathelicidin Peptide LL-37 on a Murine Sepsis Model

Isao Nagaoka

Juntendo Medical Journal, 2020

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Human anti-microbial cathelicidin peptide LL-37 suppresses the LPS-induced apoptosis of endothelial cells

Isao Nagaoka

International Immunology, 2011

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An Antimicrobial Cathelicidin Peptide, Human CAP18/LL-37, Suppresses Neutrophil Apoptosis via the Activation of Formyl-Peptide Receptor-Like 1 and P2X7

Isao Nagaoka

The Journal of Immunology, 2006

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The antimicrobial peptide LL37 modulates the inflammatory and host defense response of human neutrophils

Olaf Pinkenburg

Journal of Cystic Fibrosis, 2009

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Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

Pieter Hiemstra

Cytokine, 2009

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A Novel P2X7 Receptor Activator, the Human Cathelicidin-Derived Peptide LL37, Induces IL-1 Processing and Release

Mikhail Gavrilin

The Journal of Immunology, 2004

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A Novel P2X7 Receptor Activator, the Human Cathelicidin-Derived Peptide LL37, Induces IL-1β Processing and Release1

Mikhail Gavrilin

The Journal of Immunology

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The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium

John Govan

American Journal of Respiratory Cell and Molecular Biology, 2010

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Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses

Kelly Brown

The Journal of Immunology, 2011

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Cathelicidin Peptide LL-37 Modulates TREM-1 Expression and Inflammatory Responses to Microbial Compounds

Pieter Hiemstra

Inflammation, 2011

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A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release

Mikhail Gavrilin

Journal of immunology (Baltimore, Md. : 1950), 2004

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Cathelicidin Peptide Sheep Myeloid Antimicrobial Peptide-29 Prevents Endotoxin-induced Mortality in Rat Models of Septic Shock

C. Silvestri

American Journal of Respiratory and Critical Care Medicine, 2004

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The antimicrobial peptide cathelicidin enhances activation of lung epithelial cells by LPS

Johannes Sierigk

The FASEB Journal, 2010

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Cathelicidin Family of Antibacterial Peptides CAP18 and CAP11 Inhibit the Expression of TNF- by Blocking the Binding of LPS to CD14 Cells1

Isao Nagaoka

2001

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The human cathelicidin LL-37 — A pore-forming antibacterial peptide and host-cell modulator

Alessandro Tossi

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016

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Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats

Isao Nagaoka

Pediatric Surgery International, 2005

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Modulation of Neutrophil Apoptosis by Antimicrobial Peptides

Isao Nagaoka

ISRN Microbiology, 2012

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Identification of human cathelicidin peptide LL-37 as a ligand for macrophage integrin αMβ2 (Mac-1, CD11b/CD18) that promotes phagocytosis by opsonizing bacteria

Valeryi Lishko

Research and Reports in Biochemistry, 2016

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Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils

Isao Nagaoka

Innate Immunity, 2020

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The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses

Michael Gold, Dawn Bowdish

The Journal of Immunology, 2002

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Human Host Defense Cathelicidin Peptide LL-37 Enhances the Lipopolysaccharide Uptake by Liver Sinusoidal Endothelial Cells without Cell Activation

Isao Nagaoka

Journal of immunology (Baltimore, Md. : 1950), 2016

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LL-37 Protects Rats against Lethal Sepsis Caused by Gram-Negative Bacteria

Barbara Skerlavaj

Antimicrobial Agents and Chemotherapy, 2006

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Cutting Edge: Cationic Antimicrobial Peptides Block the Binding of Lipopolysaccharide (LPS) to LPS Binding Protein

Wim Buurman

The Journal of Immunology, 2000

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Human cathelicidin antimicrobial peptide LL-37

Kazuhiko Okumura

2000

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Antimicrobial peptide of an anti-lipopolysaccharide factor modulates of the inflammatory response in RAW264.7 cells

Cho-fat Hui, Shih-bin Lin

Peptides, 2010

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Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37

Kelly Brown

The Journal of Immunology, 2006

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Citrullination Alters Immunomodulatory Function of LL-37 Essential for Prevention of Endotoxin-Induced Sepsis

Krzysztof Pyrc

The Journal of Immunology, 2014

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P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance

Min Wan

Journal of immunology (Baltimore, Md. : 1950), 2015

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Antimicrobial cathelicidin peptide CAP11 suppresses HMGB1 release from lipopolysaccharide-stimulated mononuclear phagocytes via the prevention of necrotic cell death

Isao Nagaoka

International Journal of Molecular Medicine, 2009

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Antimicrobial peptide Cathelicidin-BF prevents intestinal barrier dysfunction in a mouse model of endotoxemia

Yizhen Wang

International immunopharmacology, 2015

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Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application

Amon Wafelman

Peptides, 2006

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In Silico Identification and Biological Evaluation of Antimicrobial Peptides Based on Human Cathelicidin LL-37

Fabrizio Carta

Antimicrobial Agents and Chemotherapy, 2006

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Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide

Daniel Weiner

Infection and immunity, 1999

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