Healthcare workers' knowledge of the carriage of meticillin-resistant Staphylococcus aureus by patients: the first step in controlling spread (original) (raw)
Journal of Hospital Infection, 2008
Abstract
results was probably confounded by serial TST and previous BCG vaccination with the possibility of false positive results secondary to cross-reaction with BCG or booster phenomenon. In fact, seven HCWs (18%) had skin induration to PPD 10 mm but did not reach the criterion for recent LTBI and therefore therapy of LTBI was not recommended. From these seven HCWs, only two (29%) resulted positive for QTBG test. We tested HCWs with QTBG test only once; thus we were unable to identify recent MTB infection by serial g-interferon measurement in previously QTBG-negative HCWs. Prospective studies of larger samples with QTBG test should help to define the criterion for QuantiFERON conversion and reversion and the incidence of booster phenomenon of QTBG induced by previous TST, allowing a better understanding of the potential role of QTBG in the screening of HCWs exposed to nosocomial risk of TB infection.
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