Correlation of target site with histology and cell culture in CT-directed stereotactic biopsy (original) (raw)

Biology of Brain Tumour, 1986

Abstract

38 suspected brain tumours were biopsied using the Brown Roberts Wells stereotactic CT guided system. Multiple target sites were biopsied in each lesion including the tumour centre and edge as defined by CT. Histology and cell culture were studied at each site. 34 tumours were identified. In 16 there was histological variation between the centre and the periphery as defined by CT. In 11 of these the enhancing edge was histologically free of tumour. 8 of these 11 were from the glioma series including 7 malignant gliomas. Cell culture studies were less conclusive but confirm that culture is feasible from small samples. Two types of short term culture were seen, those with malignant features and those without.

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