Role of the Paraventricular Nucleus Microenvironment In Stress Integration* (original) (raw)

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The hypothalamo-pituitary-adrenocortical (HPA) axis plays a critical role in the organism's response to stressors through the secretion of glucocorticoids. In the paraventricular nucleus (PVN) of the hypothalamus, neurons coordinate the endocrine response to stress, influencing multiple physiological pathways. The microanatomical complexity of the PVN facilitates a nuanced integration of signals, suggesting a sophisticated mechanism whereby various inputs are synthesized to optimize stress adaptation.

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