The Effect of a New Skin Ointment on Skin Thickness Ano Elasticity (original) (raw)
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Journal of Cosmetics, Dermatological Sciences and Applications
This study aims to evaluate the in vivo efficacy in terms of elasticity, hydration and anti-wrinkle enhancement of a new cosmetic cream formulation: Apollinea anti-ageing facial cream. The latter is O/W (oil/water) emulsion with high volume percentages of snail secretion filtrate and donkey milk serum in its composition. The investigation has been performed on (twelve) healthy subjects: 8 (eight) females, and 4 (four) males, all presenting evident skin wrinkles in typical facial areas (e.g. forehead and eye contour). The subjects had to apply about 2 grams of Apollinea anti-ageing facial cream every day. The efficacy of the new cosmetic formulation was assessed before and after the cosmetic treatment, precisely 2 hours, to assess the short-term efficacy, and 40 days after, this to evaluate the product long-term efficacy. Elasticity enhancements have been tested through measurements of the viscoelastic properties of the skin, whereas the hydration parameter through measurements of the skin and subcutaneous tissues dielectric constant. All the latter measurements have been performed with specific instrumentation, as discussed more in detail in the following. To evaluate the anti-wrinkles efficacy instead, we proceeded with digital camera imaging and image analysis processed through ImageJ software. The new Apollinea facial cream cosmetic formulation, based on donkey milk whey and snail secretion filtrate from Helix Aspersa Müller, showed significant enhancement effects on skin elasticity and hydration as well as an important skin-wrinkles-reduction.
Clinical, Cosmetic and Investigational Dermatology, 2019
Background: Sensitive skin affects an increasingly large proportion of the population and is less tolerant to frequent and prolonged use of cosmetics. This study investigates the antiaging effects of a skin care system developed for use on sensitive skin. Methods: A total of 30 healthy Caucasian females, aged 32-72, were enrolled in this doubleblind randomized placebo-controlled split-face study. A routine consisting of twice daily topical applications of the test cleanser and test moisturizer or placebo or positive control products was followed for 28 days, with parameters measured at baseline and at 7-day intervals. Objective skin assessments for hydration, transepidermal water loss (TEWL), skin surface topography, elasticity and safety assessment were conducted. Results: Wrinkle surface, length and depth significantly improved by 34.8±4.7% (P<0.001), 19.0±3.2% (P<0.05) and 24.3±3.5% (P<0.05), respectively, after 28 days of skin care treatment with the test cleanser and test moisturizer. R2 (gross elasticity), R5 (net elasticity) and R7 (biological elasticity) significantly increased by 32.8±6.5% (P<0.001), 47.3±8.6% (P<0.001) and 50.6±5.1% (P<0.001), respectively, while R6 (viscoelastic portion) significantly decreased by 33.4±4.6% (P<0.001) after 28 days. Skin hydration was also found to increase significantly after 28 days by 42.2±8.5% (P<0.01), but there was no change in TEWL. No adverse events were reported. Conclusions: A novel skin care routine developed for use on sensitive skin significantly improves the signs of aging including hydration, wrinkle size and elasticity without significant adverse effects.
Journal of Dermatology Research, 2021
Aging is a natural process undergone by every organism, with progressive changes that lead to an impairment of many biological processes. The human skin ages through several mechanisms which may cause changes to the morphology of skin leading to its reduced thickness, lower dermis density and to the presence of a subepidermal low echogenic band. These morphological changes are responsible for the visible changes of the skin such as reduced elasticity, firmness, luminosity and hydration. This study was conducted to investigate the antiageing effect and to assess the qualities and efficacy of a topical cosmetic products and a nutricosmetic product, after 84 days. Sixty women were divided into three groups and assigned different treatments (Group A: topical treatment, Group B: oral treatment and Group C: combination of topical and oral treatments). The topical treatment consisted in the application of a facial gel with alpha hydroxy acids and a facial cream with retinyl palmitate, hyaluronic acid and Vitamin C, whereas the oral treatment consisted in the daily ingestion of a drinkable solution composed of collagen peptides, astaxanthin, hyaluronic acid, vitamins and active other ingredients. Finally, Group C received a combination of the treatments in Group A and Group
Effects of alpha-lipoic acid on the biomechanical properties of the skin
World Journal of Advanced Research and Reviews, 2021
Background: The Cutometer MPA 580® (Courage and Khazaka, Germany) is a well-established instrument for the accurate and reproducible measurement of the biomechanical properties of the skin. The purpose of this study was to assess the effect of 4 formulations containing 2.5% and 5.0% of α-lipoic acid and ascorbic palmitate or butylhydroxytoluene on skin elasticity and firmness and to assess the equivalence between alternative parameters (Q0, Q1 and Q3) and the traditional parameters R0, R2, R5, R6, all determined with the same cutometer. Methods: Measure of in vivo firmness and elasticity of the skin was performed using R and Q parameters measured in the same device. Results: Different statistical analysis were applied to the results obtained from the parameters (Q0, Q1 and Q3) and the traditional parameters R0, R2, of the in vivo measurements after the application of the four formulations during 28 days. A correlation between both types of measurements was demonstrate. Conclusion: A...
Effects of -lipoic acid on the biomechanical properties of the skin
2021
Background: The Cutometer MPA 580® (Courage and Khazaka, Germany) is a well-established instrument for the accurate and reproducible measurement of the biomechanical properties of the skin. The purpose of this study was to assess the effect of 4 formulations containing 2.5% and 5.0% of α-lipoic acid and ascorbic palmitate or butylhydroxytoluene on skin elasticity and firmness and to assess the equivalence between alternative parameters (Q0, Q1 and Q3) and the traditional parameters R0, R2, R5, R6, all determined with the same cutometer. Methods: Measure of in vivo firmness and elasticity of the skin was performed using R and Q parameters measured in the same device. Results: Different statistical analysis were applied to the results obtained from the parameters (Q0, Q1 and Q3) and the traditional parameters R0, R2, of the in vivo measurements after the application of the four formulations during 28 days. A correlation between both types of measurements was demonstrate. Conclusion: A...
Cosmetics
External factors such as prolonged exposure to solar radiation and environmental pollution accelerate the aging process of the skin, and this process is a challenge for pharmacological science. To counteract the effects of skin photoaging, the cosmetic industry has introduced natural topical products that have proved to be effective in reducing signs of age. In this sense, a statistical analysis was conducted on the changes in the properties of firmness and elasticity of the skin caused by cosmetic formulas (lotion and cream) elaborated with essential oils of Aristeguietia glutinosa (matico) and Ocotea quixos (ishpingo) in which the concentration of the oils in two cosmetic products (lotion and cream) varied to be tested in vivo, through the measurement of elasticity and firmness in three times T1 (0 day), T2 (28 days) and T3 (56 days), and in two age groups according to the Glogau scale (30 to 40 and 41 to 50 years). The results showed positive changes in the values of elasticity a...
Brazilian Journal of Pharmaceutical Sciences, 2015
Lycopene, a carotenoid and potent antioxidant is found in large quantities in tomatoes. Lycopene combats diseases, such as cardiovascular disease and different types of cancer, including prostate cancer. However, its topical use in emulsion form for the combat of skin aging is under-explored. The aim of the present study was to develop an emulsion containing lycopene extracted from salad tomatoes and evaluate its cytotoxicity, stability, rheological behavior, antioxidant activity and phytocosmetic permeation. The developed cosmetic comprised an oil phase made up of shea derivatives and was evaluated in terms of its physiochemical stability, spreadability, thermal analysis, rheological behavior, microbiological quality, cytotoxicity, antioxidant activity, cutaneous permeation and retention. The results demonstrate that this phytocosmetic is stable, exhibits satisfactory rheological behavior for a topical formula and is a promising product for combating skin aging.
Conclusion: The study confirmed the well-known efficacy of biorevitalization in skin rejuvenation. Read this original research and sign up to receive Clinical, Cosmetic and Investigational Dermatology journal here: http://www.dovepress.com/antiaging-photoprotective-and-brightening-activity-in-biorevitalizatio-peer-reviewed-article-CCID
Cosmetics
Hyaluronic acid (HA) has long been used for its anti-age properties, as an ingredient in both topical applications and food supplements. In this study, a novel sodium hyaluronate, based on the innovative full spectrum technology, was administered as an ingredient of a cosmetic product and as the main constituent of a food supplement to evaluate its efficacy in counteracting skin ageing signs. Seventy-five female subjects were randomly assigned to the following treatments for 4 weeks: an active food supplement and a placebo cosmetic product, an active cosmetic product and a placebo food supplement, and a combination of the two products containing the active ingredient, that is, an “In&Out” treatment. The subjects used the placebo cosmetic product for another 14 days. Improvement of all the outcome measures (skin moisturization, elasticity, firmness and profilometry) was achieved by all treatments (p < 0.05); however, the combined treatment resulted in a further amelioration of the...
International Journal of Applied Pharmaceutics, 2021
Nutricosmetics have emerged to indicate the health benefits of the products that create beauty from inside to outside. Nutricosmetic is the latest trend in the beauty industry. Cosmeceuticals are commonly used in skincare regimens to maintain healthy skin and improve visible signs of aging. Natural products that target skin have gained great attention due to the general belief that they are harmless. A review of the biomedical literature was conducted using peer-reviewed journal articles to identify laboratory, animal, and clinical studies that have evaluated recent breakthroughs in the biological properties and potential dermatologic uses of the different natural bioactive ingredients used in nutricosmetics and Cosmeceuticals. Bioactive ingredients used in Nutri-cosmeceutical products are derived from collagen, peptides, proteins, vitamins, carotenes, minerals, omega-3 fatty acids and plant extracts. These ingredients have been shown to provide dermatologic benefits with potential applications for skin regeneration, photoprotection, wound healing, and more. The information provided by this article is valuable to get the picture of the latest trends. In addition, it might be helpful for clinicians and related manufacturing companies. Despite several developments in this field, extensive research is required for performing successful and precise clinical trials in the future. Further improvements would enable the researchers to develop new products in this field.