25-Hydroxyvitamin D and glycemic control: A cross-sectional study of children and adolescents with type 1 diabetes (original) (raw)
Related papers
American journal of nursing research, 2019
Background: Vitamin D endocrine system is a potential immune system modulator and has been implicated in the pathogenesis of several autoimmune diseases including type 1 diabetes mellitus. A relationship between type 1 diabetes and vitamin D deficiency has been reported, in which low vitamin D levels are shown to have a negative effect on beta-cell function. The aims of the study were to investigate vitamin D status and to evaluate the effect of vitamin D3 supplementation on glycemic control in children with type 1 diabetes. Method: A randomized clinical trial including 80 children who were newly diagnosed with type 1 diabetes and randomly assigned into either control or intervention arm was used. Vitamin D status and Glycohemoglobin (HbA1c) were assessed initially for both the study two arms. Diabetic children of the intervention arm who had vitamin D deficiency and insufficiency were treated with 4000 units of vitamin D3 and calcium (500 mg/day) in oral liquid form. After the study interference (3 months later), HbA1C was measured again for both arms as an indicator for glycemic control. Differences in mean±SD HbA1C and body mass index were assessed before and after the study. Results: The mean of body mass index in intervention arm was 14.77±3.49, while in control arm was 17.84±3.87, with statistically significant deference between two arms P<.001. Furthermore, the mean change in HbA1c levels in intervention arm was 6.78±1.94 compared with 7.03±1.83 in control arm, with no statistically significant deference detected between children of the study two arms P<.460. Conclusion: Vitamin D3 supplement on the clinical base improves glycemic control in pediatrics with type I diabetes mellitus and vitamin D deficiency.
The Journal of clinical endocrinology and metabolism, 2015
The role of vitamin D in the development of type 1 diabetes (T1D) remains controversial. To study whether there are detectable differences in serum 25-hydroxyvitamin D (25OHD) concentrations between children who later progressed to T1D (cases) and matched children who remained non-diabetic and negative for islet autoantibodies (controls) when followed from birth until disease onset. A total of 3702 prospective serum samples from 252 children were measured for 25(OH)D from the age of 3 months onwards using an enzyme immunoassay. Differences between the groups were compared by mixed model analysis of variance. Type 1 Diabetes Prediction and Prevention study (DIPP) clinics in Turku, Oulu and Tampere University Hospitals, Finland. By the end of 2012 all 126 case children were diagnosed with T1D. The control children (N=126) were matched for age, sex, study site and HLA-DQ-conferred risk for T1D. Median circulating 25(OH)D concentration (nmol/L). The patterns of variation in circulating ...
Indian Journal of Child Health, 2019
Background: Type 1 diabetes (T1D) is a chronic childhood disorder and is likely to be associated with dyslipidemia. Vitamin D deficiency further increases the risk of dyslipidemia; Vitamin D is believed to have cardioprotective properties. Objectives: The objective of this study was to study the effect of Vitamin D supplementation on lipid profile and glycemic control (hemoglobin A1c [HbA1c]) in children with T1D. Materials and Methods: A prospective, non-blinded, single-arm, supplementation study was performed in 145 underprivileged children with T1D from 2015 to 2017. Anthropometry, biochemical parameters (HBA1c, Vitamin D, and lipid parameters) were assessed at baseline. Children were supplemented with 1000 IU Vitamin D and 500 mg calcium daily. Follow-up data at the end of 1 year of supplementation were recorded. Results: The mean age at presentation of T1D in children was 12.5±3.9 years (65 boys). Baseline HbA1c, cholesterol, and Vitamin D were 10.3±2.1%, 4.1±1.1 mmol/L, and 33.6±18.5 nmol/L, respectively. At end line, HbA1c, cholesterol, and Vitamin D were 9.4±1.7%, 3.3±0.8 mmol/L, and 51.1±21.8 nmol/L, respectively (p<0.05 for all). Regression analysis showed that increase in Vitamin D was associated with improvement in cholesterol and HbA1c (p<0.05). Conclusion: Daily supplementation with Vitamin D along with calcium in children with T1D results in improvement in lipid profile and glycemic control.
Assessment of Vitamin D status in Type 1 Diabetes Mellitus in pediatric age group
Background: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. Type-1-Diabetes Mellitus (TIDM) results from autoimmune destruction of beta cells leading to insulin deficiency. Vitamin D deficiency (VDD) may have a role in the pathogenesis and development of T1DM by regulating immune mechanism. Materials and Methods: The aim of this study is to assess and evaluate the connection between fasting blood sugar (FBS), post prandial blood sugar (PPBS), glycated hemoglobin (HbAlc) and Vitamin D levels in children with TlDM. This study included 50 healthy controls and 50 previously diagnosed TlDM cases of both sex in the age group of 6-l5 years. 25 hydroxy Vitamin D3 (25-OH Vit D3) level was estimated by Enzyme Linked Fluorescent Assay (ELFA), FBS, PPBS by GOD-POD method, HbAlc levels by Ion Exchange Resin method. Results: Results showed a decreased 25-OH Vit D3 and an increased FBS, PPBS and HbAlc levels which are highly significant (p<0.00l) in TlDM cases than healthy controls. A highly significant negative correlation was observed between FBS, PPBS, HbAlc and 25-OH Vit D3 (P<0.00l) in TlDM cases. Conclusion: VDD has consistently been shown to be prevalent in children with TIDM, which plays an important role in its pathogenesis. Vitamin D, an immunomodulator is an important factor in glycemic control with subsequent prevention of T1DM and its further complications.
Serum Vitamin D Level in Children with and without Type 1 Diabetes Mellitus
Journal of Diabetes & Metabolism, 2016
For years, vitamin D has been associated to many immune disorders. Several studies have shown association between low serum 25 OH vitamin D and type 1 diabetes mellitus (T1DM). Objective: To compare 25 hydroxy vitamin D (25 OHD) level in T1DM patients to non-diabetic children hospitalized or seen in emergency for other diseases at the same period. Methods: It was a case-control study including 29 patients with T1DM and 28 non-diabetic control children. They were comparable in age, gender, weight, length, BMI and season of blood sampling. Epidemiological and clinical data were collected and 25OHD serum level was measured with a radioimmunoassay kit. Results: 25OHD level was significantly lower in diabetic patients (mean: 19.62 ng/ml, range 15-26 ng/ml) than in control patients (24.64 ng/ml, 20-28 ng/ml), p=0.00. All participants (T1DM patients and controls) had inadequate levels of vitamin D. Conclusion: Children with T1DM have lower vitamin D levels than control group.
Journal of clinical and diagnostic research : JCDR, 2015
Glycemic control prevents microvascular complications in patients with type I diabetes mellitus such as retinopathy, nephropathy and neuropathy that influences quality of life. Some studies show the immunomodulatory effect of vitamin D in synthesis and secretion of insulin. In this study we evaluate glycemic changes after vitamin D3 supplement in children with type I diabetes mellitus and vitamin D deficiency. In children with type I diabetes mellitus, level of vitamin D and HbA1C was measured. Patients with type I diabetes mellitus who had vitamin D deficiency (25OHD < 50 nmol/lit) treated with 300,000 units of vitamin D3. Calcium supplement (40mg/kg/day) divided in two doses in order to avoid hungry bone was also used. After three months, 25OHD and HbA1C were measured again. Differences, in mean ± SD HbA1C and 25OHD were evaluated before and after the study. Mean ± SD HbA1C was 9.73±1.85 before the study which was diminished to 8.55±1.91 after vitamin D3 supplement treatment. T...
Association among Vitamin D Deficiency, Type 1 Diabetes Mellitus and Glycemic Control
Journal of Diabetes & Metabolism, 2015
Background: Studies have identified that the deficiency of vitamin D is strongly connected with diabetes mellitus type 1. Vitamin D has the capability to control increased blood glucose level. Purpose: The study appraises the association among vitamin D deficiency, type 1 diabetes mellitus, and glycated hemoglobin among children. Methods: Around, 226 diabetic children were selected for this retrospective study from outpatient department of King Abdul Aziz University Hospital. Majority of the participants were female individuals, with the rate of 61.1% and were divided into three categories, based upon the rate of vitamin D deficiency. Every participant of the study was taking intensive insulin therapy. Results: The findings of the study have shown that 77% of the diabetic patients had reduced level of vitamin D in total. The study identified, from the evaluation between HbA1c control and vitamin D status, that 66% of the diabetic and vitamin D deficient participants were poorly controlled (HbA1c>9%). Conclusion: Vitamin D deficiency among the patients of diabetes mellitus type 1 was extremely high and was closely related with glycemic control. Additionally, the findings of the study have demonstrated therapeutic implications that the supplements of vitamin D have the potential to manage glucose level.
High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes
Background: Vitamin D is important for bone health. An inadequate supply of vitamin D to the body is associated with a higher fracture risk in the elderly. Young adults with type 1 diabetes are reported to have a lower peak bone mass than healthy individuals, which could possibly lead to an increased fracture risk in the future. The prevalence of vitamin D deficiency in healthy young people is high. Thus, optimal supply of vitamin D may be of particular importance for bone health in children with type 1 diabetes.
Journal of Pediatric Endocrinology and Metabolism, 2017
Background:The association of low serum 25 hydroxy cholecalciferol (25OHD) levels with high glucose level and diminished insulin sensitivity suggests that vitamin D (VD) may modulate insulin metabolism. The aim of the study was to screen for vitamin D deficiency (VDD) in pediatric patients with type 1 diabetes (T1D) and study the effect of VD supplementation on their glycemic control and insulin requirements.Methods:A prospective cohort study including 50 patients with T1D. VD level was assessed initially and after 3 months of VD supplementation (in those with VDD). HbAResults:Fifty patients with T1D were included with mean diabetes duration of 4.11±2.34 years. VD level ranged from 0.2 to 33 ng/mL. VD status correlated significantly with daily insulin dose (p=0.030, r=0.306) and HbAConclusions:VD was highly prevalent in Egyptian T1D patients. VD supplementation improved glycemic control at 3 months after therapy with no reduction in insulin requirements.