Prevalance and association of Helicobater Pylori with gastro-duodenal mucosal lesions in patients with dyspepsia (original) (raw)
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The Journal of medical research, 2016
Introduction: Since the discovery of H. pylori in 1983, the diagnosis and treatment of upper gastrointestinal diseases have changed greatly. A higher risk of the development of gastric cancer has been reported in subjects with positive serologic tests for H. pylori. Aims: Isolation of Helicobacter pylori from dyspeptic patient with or without ulcer and its correlation with endoscopic findings. Settings and Design: Prospective cross sectional study. Methods and Material: The study was conducted in the Department of Microbiology, SMIMS, Tadong, Gangtok for a period of 1 year (01.05.2013 – 30.04.2014) with patients with symptoms of dyspepsia. The parameters of investigation included upper gastrointestinal endoscopy, rapid urease test, Gram smear examination and isolation & identification of H. pylori by cultural technique. Results: Out of 50 patients, 32(64%) were positive for H. pylori by any of the three parameters. Of these, 26 (52%) were positive by RUT, 16(32%) by direct Gram stai...
2018
Dyspepsia which is a digestive syndrome with a prevalence of 50 in some areas can be an important factor in Helicobacter pylori infection syndrome. This study was aimed to evaluate relative frequency of Helicobacter pylori infection and histological changes in dyspeptic patients presented to the Endoscopic unit of Shahid Rahimi and Shohadaye Ashayer hospitals in Khorramabad city, Iran. In this cross-sectional study, the population included all patients with dyspepsia referred to Endoscopic Unit of Shahid Rahimi and Shohadaye Ashayer hospitals in Khorramabad during the period of 2013-2015. After performing endoscopy, H. pylori diagnosis was done by biopsy method. In this study, 5213 patients with dyspepsia (including 49.2 male and 50.8 female) with the age range of 12 to 90 years (mean 17.36 +/- 48.24 years) were studied. From this population, 57.3 percent were infected with Helicobacter pylori (50.8 of men and 49.2 women). Most positive cases were over 60 years old and the most hist...
Background and Study Aims: Helicobacter pylori (H. pylori) is considered as a public health problem, especially in developing countries. Understanding the epidemiological aspects of H. pylori infection is important and helpful in clarifying the consequences and complications of infection. The aim of this study was to assess the prevalence of H. pylori infection in dyspeptic patients and to study the demographic, endoscopic and clinical characteristics of H. pylori infected patients. Patients and Methods: A total of 113 adult patients with dyspepsia were enrolled in this study. They underwent upper gastrointestinal endoscopy for obtaining four antral biopsies, patients were considered to be infected with H. pylori when they had positive results of rapid urease and/or H.pylori stool antigen tests and confirmed by detection of H. pylori 16S rRNA gene in the extracted DNA from gastric biopsy specimens by Polymerase Chain Reaction (PCR) assay. Results: Sixty (53.1%) dyspeptic patients (17-76 years old) were confirmed to be infected with H. pylori. Age, sex, smoking history and taking spicy food had no significant correlation to the acquisition of H. pylori infection. Considering the PCR assay on gastric biopsy specimens as the gold standard, excellent agreement was found with both rapid urease and H. pylori stool antigen tests. Rapid urease test (91.7%) was more sensitive than H. pylori stool antigen test (83.3%), while both tests have specificity of 100%. Upon endoscopy; gastritis was revealed in 27(45%) and 10 (16.7%) had peptic ulcer disease (PUD). Conclusions: H. pylori infection rate in Egyptian patients with dyspepsia was high and gastritis was the most revealed finding upon endoscopy. No risk factors were associated with H. pylori infection among the studied adult patients. Combined rapid urease and stool antigen tests can be relied upon for detecting H. pylori infection.
Japanese Journal of Medical Science and Biology, 1997
Helicobacter pylori, a gram-negative, microaerophilic bacterium , has been established to have a causal association with chronic gastritis , peptic ulcer, gastric adenocarcinoma, and low-grade lymphoma. The present study was undertaken to evaluate the efficacy of culture, histological examination, the rapid urease test, and serology for the diagnosis of H. pylori infection. A total of 45 consecutive subjects with various upper gastrointestinal symptoms were included in this study. The rates of diagnosis of H, pylori infection were 51 .
Sudan journal of medical sciences, 2016
Background: There is a dearth of reports on the prevalence rate of Helicobacter pylori from the North-Central zone of Nigeria. This study aimed to determine the prevalence of H. pylori infection and its association with gastro-duodenal pathologies in patients presenting with dyspepsia in a tertiary hospital in North-Central Nigeria. Materials and Methods: One hundred and forty eight adult patients with dyspepsia underwent oesophagogastroduodenoscopy. Antral and corporal biopsy specimens were collected for histological examination. Diagnosis of H. pylori infection was made if Helicobacter-like organisms were identified in the processed specimens using Haematoxilin and Eosin, and Giemsa stains. Results: Of the 148 subjects studied, 68 (46.0%) were males and 80 (54.0%) females. The age range was 18 to 80 years with a mean of 49.5 ±15.1 years. H. pylori infection was found in 70 (47.3%) patients. Gastritis was the commonest endoscopic finding, 52 (35.1%). Others included: gastroduodenit...
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
Background: Helicobacter pylori is one of the most important infectious agents in the world. These bacteria infect 50% of the world population. Gastritis due to H. Pylori has been associated with the incidence of peptic ulcer, B cell primary lymphoma in the stomach, and gastric carcinoma. In dyspepsia, eradication of H. Pylori helps symptoms improvement and treatment cost efficiency. This study aimed to evaluate urease test in diagnosing H. Pylori infection in dyspepsia patients. It is expected that we could obtain a scientific evidence which can become the basis of routine use of urease examination in diagnosing H. Pylori infection.Method: This study used diagnostic study design. This study was performed in adult dyspepsia patients who underwent endoscopy examination in Gastrointestinal Endoscopy Centre Cipto Mangunkusumo General Hospital in January – November 2018. One biopsy sample was intended for rapid urease test using Helicotec which was performed according to the standard p...
International Surgery Journal, 2020
Background: More than half of the world’s population is infected with Helicobacter pylori, the primary cause of chronic gastritis. Chronic gastritis is associated with peptic ulcer and in advanced stages with an increased risk of developing gastric adenocarcinoma. The aim of the study was to determine the prevalence of Helicobacter pylori infection in dyspeptic patients and its relationship with gastroduodenal pathologies using gastric biopsy histology.Methods: A cross sectional prospective study was conducted from 1st January 2018 to 30th June 2019. It included out-patients and in-patients, presenting with dyspeptic symptoms and undergoing upper GI Endoscopy, at S. Nijalingappa Medical College and HSK hospital, Bagalkot, Karnataka, India. Endoscopic impressions were noted. In case of any abnormal findings on upper gastrointestinal endoscopy, endoscopic biopsy was obtained. Histopathological assessment of gastric mucosa was done after staining with H and E stain and Giemsa stain. Th...
Noninvasive diagnosis of Helicobacter pylori among patients with dyspepsia
Nepal Journal of Medical Sciences
Introduction: Helicobacter pylori (H. pylori) infection is a common disease with disparity in geography, age, race and socioeconomic status. Present study aims to assess the accuracy of noninvasive diagnostic tests. Methods: This is a hospital based cross sectional, observational study of 100 dyspeptic patients during November 2017- June 2018. Profile of dyspeptic patients were recorded in a proforma and accuracy of serology and stool antigen test for H. pylori was compared with histology detection in gastric biopsies. Results: Mean age of patients was 39.5±13.7 years with almost equal gender distribution. Prevalence of H. pylori was 56% with dyspeptic symptoms in gastric biopsies. Significant association of the infection was seen in patients with a longer duration of dyspepsia, pangastritis on endoscopy and chronic gastritis on histologic examination. Stool antigen test had good sensitivity (71%) and specificity (82%) for H. pylori detection compared with standard histological diag...
Prevalence of Helicobacter Pylori Infection in Patients with Dyspepsia in North of Iran
Middle East Journal of Digestive Diseases, 2021
BACKGROUND Dyspepsia is a common complaint among patients who refer to gastroenterology clinics. Studies have shown that there is a strong relationship between dyspepsia and Helicobacter pylori (HP) infection. We have investigated the prevalence of HP infection in patients with dyspepsia and its correlation with age and socioeconomic status (SES) of patients in Mazandaran province, northern Iran. METHODS In this cross-sectional study, patients with dyspepsia who had undergone upper gastrointestinal endoscopy were enrolled. Diagnosis of HP infection was according to the results of rapid urease test (RUT), and Giemsa staining of pathology samples. A questionnaire including endoscopic findings, demographic data, and SES information was completed for each patient. RESULTS The mean age of the 614 patients was 45.8±5 years, and 60% of them were female. Most patients had normal endoscopy (56.1%), and gastric ulcer and erosion was the most common abnormal endoscopic finding (24.7%). The prevalence of HP infection in patients with dyspepsia was about 66.6%. HP infection was associated with a lower prevalence in people aged below 30 years and good SES. CONCLUSION The prevalence of HP infection in patients with dyspepsia was 66.6%. In addition, HP infection rate was lower in people under the age of 30 years and patients with good SES.
Introduction: Helicobacter pylori, a spiral shaped pathogenic bacterium found in the human gastric mucosa, It was first isolated by Warren and Marshall in 1982 (1) and soon after was linked with chronic antral gastritis and peptic ulceration. (2) The prevalence of Helicobacter pylori is variable in different parts of the world. It is more common in developing nations. Detection of H. pylori infection is done by different modalities. None of the testing methods are considered gold standard. The yield is higher if more than one modality is used. Aims and Objectives: To study the prevalence of Helicobacter pylori infection in patients of dyspepsia undergoing upper GI endoscopy by (a)-Rapid Urease Test (RUT) and (b)-Serology (IgG and IgM ELISA). Materials and Methods:182 patients undergoing Upper GI Endoscopy were screened for H. pylori infection using Rapid Urease Test (RUT) and serology (IgM and IgG ELISA