Vitamin B3 metal-organic frameworks as potential delivery vehicles for therapeutic nitric oxide (original) (raw)
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Storage and delivery of nitric oxide via diazeniumdiolated metal organic framework
Microporous and Mesoporous Materials, 2013
Metal-organic frameworks (MOFs) are generally explored for gas adsorption and separation but more recently they have been studied for use in biomedical applications. The present study focuses on the incorporation of a nitric oxide (NO) donor, called a diazeniumdiolate (NONOate), into a new MOF using a one-step post-synthetic method. The MOF, Cu-TDPAT, contains copper nodes linked by 2,4,6tris(3,5-dicarboxylphenylamino)-1,3,5-triazine (H 6 TDPAT). This MOF adsorbs NO and the TDPAT linker contains secondary amines which react with NO to form a NONOate. The covalently bound NONOate donor group allows for greater control over the NO storage and delivery rate. Over the course of 7 days, the Cu-TDPAT NONOate will yield approximately 175 lmol/g NO by exposure to 85% humidity and 53 lmol/g NO by heating to 37°C.
Biomedical Applications of Metal Organic Frameworks
Industrial & Engineering Chemistry Research, 2011
We have witnessed a rapid growth in the field of a new nanoporous material group, metal organic frameworks (MOFs), over the past decade. MOFs possess a wide array of potential applications in chemical engineering, chemistry, and materials science, including gas storage, gas separation, and catalysis. One of the areas MOFs started to appear recently is biomedical applications. The unique physical and chemical characteristics of MOFs make them promising candidates for drug storage and drug delivery, nitric oxide storage and delivery, imaging, and sensing. In this review, we outline the recent progress of using MOFs as a promising platform in biomedical applications due to their high drug loading capacity, biodegradability, and versatile functionality. We also demonstrate the potential of MOFs for continuous development and implementation in biomedical applications by discussing issues including stability, toxicology, and biocompatibility. Although significant progress has been made in utilizing MOFs for biomedical applications, further improvements must still occur before MOFs can become viable therapeutics options.
Design and degradation of permanently porous vitamin C and zinc-based metal-organic framework
Communications Chemistry, 2022
Bioapplication is an emerging field of metal-organic frameworks (MOF) utilization, but biocompatible MOFs with permanent porosity are still a rarity in the field. In addition, biocompatibility of MOF constituents is often overlooked when designing bioMOF systems, intended for drug delivery. Herein, we present the a Zn(II) bioMOF based on vitamin C as an independent ligand (bioNICS-1) forming a three-dimensional chiral framework with permanent microporosity. Comprehensive study of structure stability in biorelavant media in static and dynamic conditions demonstrates relatively high structure resistivity, retaining a high degree of its parent specific surface area. Robustness of the 3D framework enables a slow degradation process, resulting in controllable release of bioactive components, as confirmed by kinetic studies. BioNICS-1 can thus be considered as a suitable candidate for the design of a small drug molecule delivery system, which was demonstrated by successful loading and rel...
Journal of nanoscience and nanotechnology, 2018
Metal-organic frameworks (MOFs) are highly crystalline porous organic-inorganic materials that are comprised of metal salts and organic linkers. The common synthetic methodologies of MOFs include: solvothermal, microwave-assisted, electrochemical, mechanochemical, and sonochemical routes. The synthesized MOF particles can be characterized using several characterization techniques including: X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and other analytical techniques. Recently, MOFs have garnered increasing attention due to their potential applications in numerous areas including: catalysis, gas storage and separation, drug delivery, and others. In this research paper, a new metal-organic framework was synthesized successfully from iron nitrate and 2,6-naphthalenedicarboxylic acid (1) by means of microwave irradiation (Fe-NDC-M) and (2) solvothermally using a conventional electric oven (Fe-NDC-O). They were characterized...
Metal-organic frameworks: A novel platform for combined advanced therapies
Coordination Chemistry Reviews, 2019
Different strategies have been developed to overcome limitations of traditional pharmacological treatments (biodegradation, low specificity, toxicity, side effects). Remarkably, the use of nanoplatforms as Drug Delivery Systems (DDS) to control the dose and the delivery kinetics of active ingredients (AIs) stands out as promising new generation of personalized therapies. Among other proposed materials, Metal-Organic Frameworks (MOFs) offer multiple versatilities for the accommodation of AIs: adaptable structure based on organic ligands and inorganic clusters as building units (BUs), that can be AIs themselves; accessible porosity and large surface areas; availability of functionalization sites; and biodegradability, among others. It is of great importance that MOFs, selected as bioplatforms, are biocompatible and do not exhibit toxicity. Even there are plenty of studies and reviews that explored the use of MOFs as DDS, they often include a single AI. In contrast, we wanted to focus on this review on MOF bioplatforms that exhibit advanced combined therapies. These advanced therapies could be achieved by: i) the co-encapsulation and simultaneous or sequential release of two or more AIs (e.g. drugs, metals,
Metal-Organic Frameworks in Systems of Drug Delivery: Review
Iranian Journal of Chemical Engineering, 2023
Drug delivery systems (DDSs) have become a crucial aspect of cancer therapy, and researchers are continuously striving to identify the optimal methods for targeted delivery and release of therapeutic agents. Metal-Organic Frameworks (MOFs) have emerged as a promising class of materials for DDSs due to their exceptional storage capacity, unique characteristics, and high durability. This comprehensive review explores the wide-ranging applications of MOFs in various fields, including catalysis, gas separation and storage, fuel purification, water treatment, medication administration, and imaging. The review paper evaluates different approaches to synthesize MOFs, such as self-assembly of metal ions and clusters and the solvothermal method, to optimize their performance characteristics. The present study aims to shed light on the numerous challenges associated with utilizing MOFs in clinical settings. However, MOF nanocomposites that incorporate reinforcement phases represents a promising strategy for addressing these issues. With the incidence of cancer on the rise, targeted MOFs offer a potential solution to the lack of selectivity of certain drugs by virtue of their distinctive physical and chemical properties. This investigation delves into how MOFs can be employed to regulate drug release in DDSs and presents research on key applications of MOFs in the realm of cancer therapy. The application of UiO-66 for drug delivery systems and explore the different physical characteristics and chemical structures of dicarboxylate ligands incorporated into UiO-66 topology MOFs were investigated. Overall, the review paper provides a comprehensive overview of the diverse applications of MOFs and their potential for drug delivery systems in cancer therapy.
Gradual Release of Strongly-Bound Nitric Oxide from Fe 2 (NO) 2 (dobdc)
Journal of the American Chemical Society, 2015
An iron(II)-based metal−organic framework featuring coordinatively unsaturated redox-active metal cation sites, Fe 2 (dobdc) (dobdc 4− = 2,5-dioxido-1,4-benzenedicarboxylate), is shown to strongly bind nitric oxide at 298 K. Adsorption isotherms indicate an adsorption capacity greater than 16 wt %, corresponding to the adsorption of one NO molecule per iron center. Infrared, UV−vis, and Mossbauer spectroscopies, together with magnetic susceptibility data, confirm the strong binding is a result of electron transfer from the Fe II sites to form Fe III −NO − adducts. Consistent with these results, powder neutron diffraction experiments indicate that NO is bound to the iron centers of the framework with an Fe− NO separation of 1.77(1) Å and an Fe−N−O angle of 150.9(5)°. The nitric oxide-containing material, Fe 2 (NO) 2 (dobdc), steadily releases bound NO under humid conditions over the course of more than 10 days, suggesting it, and potential future iron(II)-based metal− organic frameworks, are good candidates for certain biomedical applications. M etal−organic frameworks, which have received a great deal of attention for gas storage and molecular separations, 1 have also recently shown promise for applications in biomedicine, typically for drug storage and delivery. 2 Although a number of structures have been synthesized from biologically active ligands, 3 bioactive molecules can also be incorporated into a metal−organic framework postsynthetically 4 or produced via the catalytic decomposition of precursor molecules such as S-nitrosothiols. 5 An important example of this is the adsorption and release of nitric oxide by frameworks featuring coordinatively unsaturated metal centers. The first investigation involved the widely studied metal−organic framework Cu 3 (btc) 2 (btc 3− = 1,3,5-benzenetricarboxylate, HKUST-1). 6,7 This compound adsorbs nearly 4.0 mmol/g of NO, a significant improvement over zeolites, which can adsorb NO with maximum capacities of 1 mmol/g under similar conditions. 8 Upon exposing HKUST-1 to humid air, a slow release of a fraction of the coordinated NO occurs over the course of an hour. Although the amount released is limited to just ∼2 μmol/g, it proved sufficient to inhibit platelet aggregation in biological experiments, which is necessary to prevent blood clotting. In addition to antithrombotic applications, porous materials that can store and deliver the critical biological signaling molecule NO may be useful for antibacterial and wound healing applications. 9 In order to improve upon the NO release properties of HKUST-1, storage and release by Ni 2 (dobdc) and Co 2 (dobdc) were subsequently studied. 10,11 These materials feature exceptionally high densities of coordinatively unsaturated metal cations and are unable to form the M I −NO + adducts likely responsible for the poor NO release displayed by HKUST-1. Indeed, the frameworks adsorbed close to 7 mmol/g NO at room temperature and released the entire quantity within 15 h of exposure to humid air. These frameworks, however, suffer from biocompatibility issues, as they are based on cobalt or nickel. The NO storage and release properties of a family of biocompatible MIL-88(Fe)-based metal−organic frameworks were recently reported. 12 However, these materials adsorb and release <0.35 mmol of NO per gram, significantly less than the M 2 (dobdc) frameworks.
Journal of Inorganic and Organometallic Polymers and Materials, 2013
Reaction of terephthalic acid and pyrazine with nickel nitrate under hydrothermal conditions forms a 3D metal-organic framework with the composition of [Ni(l 3tp)(l 2-pyz)] n (1), where H 2 tp = 1,4-benzenedicarboxylic acid (terephthalic acid) and pyz = pyrazine. X-ray single crystal analysis reveals that Ni(II) centers adopt a distorted octahedral geometry which are surrounded by four oxygen atoms from three tp groups and two nitrogen atoms of pyrazine molecules in equatorial and axial positions, respectively. Coordination of Ni(II) centers by terephthalate linkers in ac plane forms infinite (4, 4)-connected 2D layers, which are further joined together by pyrazine groups to form an interlocked 3D structure. Topological studies show a twofold interpenetrated uninodal 3D network with point symbol of (4 12 Á6 3). The polymer shows a blue emission band at 467 nm in the solid state at room temperature. The X-ray power diffractions (PXRD) and thermal gravimetric analysis of 1 are also presented and discussed. NiO nanoparticles have been prepared via direct calcination of 1 at 600°C, with sizes of about 35-45 nm. Nanoparticles were further characterized by IR, scanning electron microscopy equipped with energy dispersive X-ray analyses and PXRD technique.
Applications of Metal-Organic Frameworks as Drug Delivery Systems
International Journal of Molecular Sciences
In the last decade, metal organic frameworks (MOFs) have shown great prospective as new drug delivery systems (DDSs) due to their unique properties: these materials exhibit fascinating architectures, surfaces, composition, and a rich chemistry of these compounds. The DSSs allow the release of the active pharmaceutical ingredient to accomplish a desired therapeutic response. Over the past few decades, there has been exponential growth of many new classes of coordination polymers, and MOFs have gained popularity over other identified systems due to their higher biocompatibility and versatile loading capabilities. This review presents and assesses the most recent research, findings, and challenges associated with the use of MOFs as DDSs. Among the most commonly used MOFs for investigated-purpose MOFs, coordination polymers and metal complexes based on synthetic and natural polymers, are well known. Specific attention is given to the stimuli- and multistimuli-responsive MOFs-based DDSs....