Minocycline-releasing PMMA system as a space maintainer for staged bone reconstructions - in vitro antibacterial, cytocompatibility and anti-inflammatory characterization (original) (raw)

Biomedical materials (Bristol, England), 2017

Abstract

In the present work, it is aimed the development and biological characterization of a poly methyl methacrylate (PMMA)-based minocycline delivery system, to be used as a space maintainer within craniofacial staged regenerative interventions. Developed delivery systems were characterized regarding solid state characteristics and assayed in vitro for anti-bacterial and anti-inflammatory activity, and cytocompatibility with human bone cells. Drug release profile allowed for an initial burst release and a more sustained and controlled release over time, with minimum inhibitory concentrations for the assayed and relevant pathogenic bacteria (i.e, Staphylococcus aureus, slime-producer-S. epidermidis and Escherichia coli) being easily attained in the early time points, and sustained up to 72 hours. Furthermore, an improved osteoblastic cell response - with enhancement of cell adhesion and cell proliferation - and increased anti-inflammatory activity were verified in developed systems, as co...

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