Ameliorative Activity of Punica granatum Extracts and Ellagic acid against Radiation Induced Biochemical Changes in Swiss Albino Mice (original) (raw)

Abstract

Radiation therapy has been used in cancer treatment for many decades; although effective in killing tumor cells, Reactive Oxygen Species (ROS) produced in radiotherapy threaten the integrity and survival of surrounding normal cells. ROS are scavenged by radioprotectors before they can interact with biochemical molecules, thus reducing harmful effects of radiation. The objective of the present study was to investigate the protective efficacy of ethanolic extracts of pomegranate whole fruit (EPWF) and seeds (EPS) and Synthetic Ellagic acid (EA) against Electron beam radiation (EBR) induced biochemical alterations in Swiss Albino mice. The animals were exposed to sub-lethal dose (6Gy) of Electron Beam Radiation and then treated with100, 200 and 400mg/kg body wt. of pomegranate extracts and synthetic ellagic acid for 15 consecutive days. The biochemical estimations were carried out in the liver homogenate of the sacrificed animals. Test groups exhibited elevation in the levels of antiox...

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