Characterization and Bioscreening of a New Triterpenoid and a Flavanone Isolated fromSalvia nubicola (original) (raw)
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Iranian journal of pharmaceutical research : IJPR, 2013
Two flavones, ladanein and 6-hydroxy-5,7,4'-trimethoxyflavone and one labdane-type diterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract of the aerial parts of Salvia sharifii. The compounds were purified using several chromatographic methods. Structural elucidation of the compounds was performed using their (1)H and (13)C-NMR data, EI mass and UV spectral data. The compounds have been subjected to antimicrobial, antioxidant and cytotoxic activity. The diterpene showed higher cytotoxic activity than the flavones while the later compounds were better antioxidants compared with the isolated diterpene.
Two flavones, ladanein and 6-hydroxy-5,7,4′-trimethoxyflavone and one labdane-type diterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract of the aerial parts of Salvia sharifii. The compounds were purified using several chromatographic methods. Structural elucidation of the compounds was performed using their 1 H and 13 C-NMR data, EI mass and UV spectral data. The compounds have been subjected to antimicrobial, antioxidant and cytotoxic activity. The diterpene showed higher cytotoxic activity than the flavones while the later compounds were better antioxidants compared with the isolated diterpene.
Bioactive Diterpenoids Isolated from Salvia mellifera
Phytotherapy Research, 1996
Eight diterpenoids were isolated from the roots of Sulvia rnelliferu Greene. Their structures were elucidated by comparison to their physical and spectroscopy data with those reported in the literature or that of authentic samples as: abieta-8,11,13-triene, ferruginol, 15-deoxi-fuerstione, taxodione, isotanishinone 111, rolyeanone, 7a-hydroxi-rolyleanone and demethylsalvicanol. Demethylsalvican-11-12-dione was obtained by oxidation with Ag20 from demethylsalvicanol. Compounds ferruginol, taxodione, isotanshinone 111, and 7a-hydroxiroyleanone showed cytotoxic activity against both HeLa and Hep-2 cells in culture. Royleanone and demethylsalvican-11-12-dione were active on Hep-2 and HeLa cells respectively. Antimicrobial activity against some Gram (+) bacteria was observed for the diterpenoids ferruginol, taxodione, 7a-hydroxi-royleanone and demethylsalvican-11-12-dione. None of them was active on Gram (-) bacteria or Cundida albicans.
Abietane diterpenoids from Salvia chinopeplica
Phytochemistry, 1998
A new aromatic diterpene has been isolated from the leaves of Salvia chinopeplica and its structure established on the basis of spectral data as 19-hydroxy-royleanone. The known diterpenes carnosol, 16hydroxy-carnosol, 16-hydroxy-20-deoxo-carnosol, 16-hydroxy-carnosic acid, 16-hydroxy-ferruginol, 7~methoxy-rosmanol and 11,12,16-trihydroxy-20-nor-abietan-5 (10),8,11,13-tetraen-lone , as well as ursolic acid and the flavonoids velutin, salvigenin and 3,5-dihydroxy-7,4'-dimethoxy-flavone were also isolated from the same source.
SALVIA GENUS: MINOR ISOLATED TRITERPENOID(S
In this review article, our focus is on the Minor avail triterpenoids, found in Salvia species such as Dammarens, and other critical structure type triterpenoids. This review article compiled almost 28 triterpenoids from about 15 species of salvia which were reported from literature survey till date. This review is an effort to attract natural product chemist to give their contribution on isolation of these critical structure type triterpenoid's for better understanding of natural product chemistry.
Bioactive Triterpenoids from Salvia Species ⊥
Journal of Natural Products, 2006
Salvia species new triterpenoid(s) known triterpenoid(s) reference(s) S. aegyptiaca L. α-amyrin β-amyrin 3β-hydroxy-oleana-11,13(18)-dien-28-oic acid lupeol oleanolic acid ursolic acid 107, 117 S. amplexicaulis Lam. α-amyrin β-amyrin acetyloleanolic acid oleanolic acid ursolic acid 105, 114 S. anastomosans Ramamoorthy oleanolic acid ursolic acid 118 S. apiana Jeps. 3β-acetoxy-28-oxo-olean-12-ene 3β-acetoxy-28-oxo-urs-12-ene 3β-acetyloleanolic acid 3β-acetylursolic acid α-amyrin β-amyrin 3β,28-dihydroxy-olean-12-ene 3β,28-dihydroxy-urs-12-ene oleanolic acid ursolic acid 119 S. argentea L. 3β-acetoxy-olean-12-ene-2α,11α-diol 3β-acetoxy-olean-12-ene-1β,2α,11α-trio1 3β-acetoxy-urs-12-ene-2α,11α-diol 3β-acetoxy-urs-l2-ene-2α,11α,20β-triol 3β-acetoxy-urs-12-ene-1β,2α, 11α-trio1 3β-acetoxy-urs-12-ene-1β,2α,11α,20β-tetrao1 oleanolic acid ursolic acid 57 S. aspera M. et G. amblyol amblyone oleanolic acid 41 S. aucheri var. canescens Benth.