Trends in Primary Brain Tumors: A 5-Year Retrospective Histologically Confirmed Study in Tabriz, Iran, 2011-2016 Original Article (original) (raw)
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International Journal of Cancer Management, 2018
Background: The central nervous system (CNS) belongs to heterogeneous group of glial and non-glial brain tumors. Increase in the frequency of brain and CNS tumors in Iran have been a cause for debate and concern. Objectives: The aim of this study was to estimate the frequency of the principal CNS cancers, using CNS cancer data records in a 7-year period in a hospital in Mashhad, Iran. Methods: This study is based on the records of department of surgical pathology, Razavi hospital, Mashhad, Iran. We analyzed 1,164 brain tumors and CNS cancers diagnosed from 2006 to 2013. It includes data on spinal cord tumors, primary brain such as lymphomas, which are hematological malignancies and metastatic tumors originating from external to the central nervous system. The frequency varies widely across this 7-year period. Results: The majority of brain tumor locations were frontal (13.2%), pituitary (11.7%), parietal (10.6%), Spinal (8.9%), Temporal (8%), and base of skull (6.3%). The most frequently reported histologies were meningiomas (33.6%) and glioblastomamultiforme (15.8%) that are strongly influenced the overall results. Higher numbers for glioblastoma, myxopapillaryependymoma, fibrillary astrocytoma, craniopharyngioma, hemangio-blastoma, oligodendro-glioma, and sarcoma were observed in male than in female patients. Meningioma, neurofibroma, and choroid plexus papilloma were the only tumors with a significant excess in female. Conclusions: We noted that higher frequency of brain tumors and CNS cancers occurred at age group of 51 to 60 years. Although data are hospital-based, is the first study to delineate the brain tumors and CNS cancers burden in northeast of Iran by age, sex, histology type, anatomical site, and laterality.
Incidence trends in high-grade primary brain tumors in males and females
Oncology letters, 2017
The focus of the present review is to investigate whether there is a variation in the incidence rates between male and female patients with high-grade primary brain tumors and if there are altered incidence rates associated with the time at which they were diagnosed. Previous studies identified in internationally peer-reviewed journals were identified using a systematic search of the PubMed database. Due to the difficulties in data interpretation, studies that exclusively included patient data classified prior to the 2nd edition of the World Health Organization histological classification system of brain tumors were excluded. The overall incidence rates and incidence trends of male and female patients were analyzed separately. The mean age-adjusted overall incidence rate in the male population was 1.27 per 100,000 compared with 0.89 per 100,000 in the female population. The variance between the two genders differed and a Wilcoxon rank-sum test indicated that there was no significant...
Spectrum of Brain Tumors in a Tertiary Care Hospital: A 5 Years Study
Background-Tumor epidemiology is a significant part in case of intracranial tumor studies. Here, we discuss the features of intracranial tumor pathology in single centre. Aims and Objective-To analyze the age,sex and site wise distribution of different histological pattern of intracranial tumors seen in our centre. Materials and Methods-It is a retrospective study of cases of intracranial tumors seen over a period of 5 years .Altogether 160 CNS specimens were fixed in 10% Formalin and processed in automatic tissue processor. Routine Hematoxylin and Eosin stain and special stains were done and examined under the light microscope. The diagnosis is given on the basis of age,sex distribution using the WHO grading and the histological subtypes.Results-Out of total 160 cases of intracranial tumor 86 cases were of meningioma (53.75%). 30 cases were of astrocytoma (18.75%).13 cases are of pituitary adenoma (8.125%) .11 cases were of schwannoma (6.875).5 cases were of glioblastoma grade 4 (3.125%).5 cases were of oligodendroglioma grade 2 (3.125%).2 cases were of each metastatic carcinoma, ependymoma,cerebellar hemangioblastoma and tuberculoma (1.25%).1 case of each central neurocytoma and craniopharyngioma (0.625%).In this study meningioma is the most common intracranial tumor followed by astrocytoma.Conclusion-Meningiomas are commonest tumor and comprise more than half of all operated CNS tumors in our setup, followed by astrocytomas.Meningothelial Meningioma is the most common subtype.This study can help in observing CNS tumor trends and changing patterns.
The aim of this study was to analyze distribution and proportion of intracranial tumors from data obtained at "Ljudevit Jurak" University Department of Pathology from 1989 to 2002. The data from our computer database were analyzed according to the histological diagnosis, patient age (four groups), and sex. There were 2403 intracranial tumors, out of which 667 (27,8%) were malignant gliomas ( anaplastic astrocytomas and glioblastomas), 593 (24.7%) meningiomas, 328 (13.6%) pituitary adenomas, 159 (6.6%) schwannomas and the others 13.7%. Metastatic intracranial tumors were diagnosed in 326 (13.6%) patients. We found statistically significant trends of increasing incidence over time in the oldest age group (over 65years of age) for meningiomas in women, and for malignant gliomas for both sexes. The observed distribution and proportion of intracranial tumors are predominantly in accordance with the recent European, North American, and Japanese reported studies.
Open Journal of Epidemiology, 2014
Most epidemiology reports indicate that brain tumor rates in whites are higher than other populations and that they are more common in males than females. In this report, we analyze incidence patterns in registry data from the Surveillance, Epidemiology, and End Results program in different histological groups, racial/gender combinations and compare the overall and age-specific incidence rates. Our analysis shows statistically significant racial differences in rates for astrocytomas non-otherwise specified in both sexes, and unspecified malignant intracranial intraspinal neoplasms for females. Those of other specified intracranial and intraspinal neoplasms in females are higher than males, indicating the importance of biological differences. Other glioma young age rates peak after the age of five, the peak is higher for the black race. The study demonstrated several distinctive patterns in the rates by histological subtypes and showed differentiation in the age at diagnosis, giving insight on potential true changes in different subpopulations.
Biomedical Research, 2018
Background: Brain tumors are associated with marked disability and mortality. Understanding the patterns and epidemiological characteristics associated with brain tumors can be crucial to their treatment. Objective: To explore the magnitude and epidemiological features of primary brain tumors among patients admitted to Aseer Central Hospital (ACH), Abha City, Saudi Arabia, and to identify different decisions for their management. Methodology: All hospital records of brain tumor patients admitted to ACH from 2015-2017 were reviewed. Collected data included patients' demographic characteristics, clinical findings, histopathological diagnosis, and management. Results: During the aforementioned period, a total of 100 patients with primary brain tumors were admitted to ACH. The most commonly presenting symptoms were headache (72%), vomiting, dizziness, and focal motor deficits (25% for all). Tumor location was mostly at the frontal or parietal lobes. Among those who underwent surgery, meningioma grade I was the most frequently diagnosed (41.7%). The mean surgical time was 4.2 ± 1.6 h. Most patients who underwent surgery at ACH stayed in the intensive care unit anywhere from 1 d or 2-4 d (34% and 40%, respectively). The Glasgow outcome scale scores of most patients (91.7%) indicated that the patients had a good recovery. However, one patient died (1.7%), one was in a persistent vegetative state (1.7%), and three sustained moderate disability (5%). Conclusion: Most patients with brain tumors admitted to ACH undergo surgery. Meningioma grade I is the most commonly encountered brain tumor, and this finding may reflect different epidemiological findings from the internationally accepted concept that glioblastoma multiforme is the most common brain tumor. The most common locations for brain tumors are the frontal and parietal lobes.
Journal of Neuro-Oncology
Introduction We used data from MOBI-Kids, a 14-country international collaborative case–control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). Methods Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. Results Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and ‘non-neuroepithelial’ tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that ...
2020
with a diagnosis of primary CNS tumor (brain and spinal cord) were selected. Data about sex, age, tumor location, and histologic type were collected. The classification was based on the International Classification of Diseases for Oncology, 3rd Edition (ICD-O-3). Results. Nine hundred and ninety-two (992) cases of primary CNS tumors throughout the ten years (2005 to 2014) were reviewed. There were 714 (71.97%) adults and 278 (28.02%) in the pediatric age group. Nonmalignant tumors dominated the adult population (60.08%) while malignant tumors were more frequent in the pediatric population. Gliomas constituted the most common neoplastic category in children and adults. The most common single tumor entity was meningioma (26.99%, ICD-O-3 histology codes 9530/0, 9539/1, and 9530/3). Medulloblastomas (ICD-O-3 histology codes 9470, 9471, and 9474) were the most common single tumor entity in the pediatric age group (26.62%). Conclusions. This is an institution-based, detailed, and descriptive epidemiological study of patients with primary CNS tumors in Saudi Arabia. In contrast to other regional and international studies, the medulloblastomas in our institution are more frequent than pilocytic astrocytomas. Limitations to our study included the referral bias and histology-based methodology.